Detail Information

Basic Information:


  VIRBase ID:  

HVID00001861

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 2a,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9820

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-199a-3p POLY
miRBase
Accession/Entrez ID		 MIMAT0000232 11027172
Organism Homo sapiens Hepacivirus C (Hepatitis C virus subtype 2a,HCV)
Category miRNA mRNA
Alias - HCV2_gp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-199a-3p
rs1244221007 chr19:10817432    C/G
rs1281197836 chr19:10817437    G/A
rs1315393563 chr19:10817435    A/G
rs746524562 chr19:10817434    A/G
rs746524562 chr19:10817434    A/T
rs961039315 chr19:10817436    T/C
rs990986317 chr19:10817442    G/A
rs1161021809 chr1:172144560    A/G
rs1482780016 chr19:10817448    T/C
rs183664554 chr19:10817443    A/G
rs771220698 chr19:10817447    C/T
rs776326431 chr19:10817446    A/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-199a-3p
Exosome Peripheral blood mononuclear cells     19002258
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Endothelial cells     -
Extracellular Vesicle Liposarcoma cell lines (Lipo224B|Lipo246|Lipo863|LPS141)|Preadipocytes     28588009
Microvesicle Plasma     19002258
Microvesicle Plasma     23077538
Microvesicle Follicular fluid     23666971
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-199a-3p
Curcumin 969516 Drug interaction    RC00001534
Ethanol 702 Drug interaction    RC00001528
Gemcitabine 60750 Drug interaction    RC00001533
Enoxacin 3229 Drug interaction    RC00001530
Emodin 3220 Drug interaction    RC00001529
Doxorubicin 31703 Drug interaction    RC00001532
Arsenic trioxide 14888 Drug interaction    RC00001531
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-199a-3p
Cisplatin 5702198       26261572
Cisplatin 5702198       28126676
Cisplatin 5702198       28422725
Cisplatin 5702198       28743276
Cisplatin 5702198       29436681
Cisplatin 5702198       29866054
Carboplatin 426756       29866054
Doxorubicin 31703       20501828
Doxorubicin 31703       21055388
Doxorubicin 31703       26079799
Doxorubicin 31703       29866054
Docetaxel 148124       21807947

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-199a-3p
Interactor2: POLY

Evidence Support:


Strong-Evidence Ago2-IP//Luciferase reporter assay//qPCR//Western blot
Support Database VIRmiRNA//VmiReg

References:


PMID 19144437 Target region 3'UTR//5'UTR
Source VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line JFH1 cells//MH14 cells//SN1a cells Interactor2 expression None
Description Overexpression of miR-199a* inhibited HCV genome replication in two cells bearing replicons (replicon cell) HCV-1b or -2a, however, miRNA inhibition by specific antisense oligonucleotide (ASO) accelerated viral replication.

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