Detail Information

Basic Information:


  VIRBase ID:  

HVID00000006

  Virus:  

Porcine reproductive and respiratory syndrome virus (PRRSV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-505-3p PRRSVgp4
miRBase
Accession/Entrez ID		 MIMAT0002876 1494891
Organism Homo sapiens Porcine reproductive and respiratory syndrome virus (PRRSV)
Category miRNA mRNA
Alias - PRRSVgp4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-505-3p
rs1399022406 chrX:139924172    A/C
rs752398973 chrX:139924166    C/T
rs769780782 chrX:139924181    G/A
rs1164352633 chrX:139924164    AACCAGCAAGTGTTG/A
rs143213653 chrX:139924180    C/T
rs751353935 chrX:139924177    T/C
rs762594106 chrX:139924174    T/A
rs763934588 chrX:139924176    T/C
rs763934588 chrX:139924176    T/G

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-505-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-505-3p
4-Thiazolidinone, 3-(1-phenylethyl)-2-thioxo- 99773 Drug sensitive
Sensorad 99342 Drug sensitive
Curcumin 969516 Drug sensitive
5-Iodo-8-quinolinol 96111 Drug sensitive
Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive
Actinomycin X4357G methoxime 9573583 Drug sensitive
[[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug sensitive
4-(1,3-Benzoxazol-2-yl)aniline 88733 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
Arjunolic acid 73641 Drug sensitive
Morpholine-N-dithiocarbamate 72675 Drug sensitive
4,4'-Bis(dimethylamino)thiobenzophenone 71045 Drug sensitive
Tolonium chloride 7083 Drug sensitive
Azure B 68275 Drug sensitive
Melicopidine 68060 Drug sensitive
Sulbentine 67686 Drug sensitive
3-Hydroxy-3'-nitro-2-naphthanilide 67277 Drug sensitive
Baccharinoid B4 6711263 Drug sensitive
Reactive Blue 2 656725 Drug sensitive
Indazole analogue 17 6539599 Drug sensitive
N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive
Baccatin III 65366 Drug sensitive
Ixabepilone 6445540 Drug sensitive
Methylene blue 6099 Drug sensitive
Piriqualone 6015423 Drug sensitive
Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive
3-[[4-[[2-(Methoxycarbonylamino)-3H-benzimidazol-5-yl]oxy]phenyl]carbamoylamino]benzoic acid;hydrochloride 57399799 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
(3beta)-3-((4-O-beta-D Glucopyranosyl-beta-D-xylopyranosyl)oxy)-14-hydroxy-19-oxocarda-4,20(22)-dienolide 56840951 Drug sensitive
Antibiotic 1907-VIII 5477807 Drug sensitive
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
Artelasticin 5471311 Drug sensitive
Antineoplastic-643001 5466797 Drug sensitive
Withacnistin 54606507 Drug sensitive
2, 2'-(4-Ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-, trihydrochloride 54600704 Drug sensitive
Dysorone E 5459221 Drug sensitive
Thiram 5455 Drug sensitive
(E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
Dihydro-5-azacytidine 5351280 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
5-[2-(4-Hydroxy-2,6-dimethylphenyl)ethenyl]pyridine-3-carboxamide 53239975 Drug sensitive
Rhamnazin 5320945 Drug sensitive
Centaureidin 5315773 Drug sensitive
Peridinin 5289155 Drug sensitive
8-Hydroxymanzamine A 5270765 Drug sensitive
Spiperone 5265 Drug resistant
Kekule 499328 Drug sensitive
Ammonia; dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498559 Drug sensitive
Pipamperone 4830 Drug sensitive
1-[2-(3-Chlorophenyl)-2-oxoethyl]-2-acetylbenzimidazole 46911792 Drug sensitive
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
N-Methyl-1,5-bis(4-cyanophenoxy)-3-aza-pentane 45028719 Drug sensitive
Isopinnatal 44558939 Drug sensitive
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Neriifolin 441867 Drug sensitive
Isobrucein A 441802 Drug sensitive
Glaucarubinone 441796 Drug sensitive
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide 42640 Drug sensitive
S-(Diethylarsino)-3-mercapto-1,2-propanediol 406476 Drug sensitive
Ethanone, 1-[3-(bromomethyl)-1,4-dioxido-2-quinoxalinyl]- 404859 Drug sensitive
2-[(Phenylamino)methyl]benzene-1,4-diol 403336 Drug sensitive
3-[(2-Bromoacetyl)amino]-N-carbamoylbenzamide 398525 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
Lomustine 3950 Drug sensitive
Amino MMI-S02 CI 393532 Drug sensitive
Sjg-136 393111 Drug sensitive
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive
15-Oxozoapatlin 391317 Drug sensitive
Isopropyl 4-(2-(4-bromo-2,5-dihydroxyphenyl)ethyl)benzoate 389288 Drug sensitive
Cardenolide 2 388098 Drug sensitive
Benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2-acetyl- 388028 Drug sensitive
2-(1-Propynyl)estradiol 388008 Drug sensitive
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug sensitive
4-Methylthio-N-(3,4,5-trimethoxybenzyl)aniline 373808 Drug sensitive
N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive
Antineoplastic-645804 371505 Drug sensitive
11H-Benzo[a]carbazole-1,4-dione, 7,11-dimethyl- 371271 Drug sensitive
Sanguilutine pseudobase 371258 Drug sensitive
Tetrakis(8-chinolineolato)titanium(IV)-tetrahydrochloride 368279 Drug sensitive
Tris(tropolonato)samarium(III) 366262 Drug sensitive
[1-(2-Benzyl-3-methoxy-5-oxo-2H-pyrrol-1-yl)-3-methyl-1-oxobutan-2-yl] 1-[1-[2-[[2-[[2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylate 357989 Drug sensitive
1-Chloro-3-(3-chloropropylsulfonylsulfanyl)propane 355643 Drug sensitive
Maxima isoflavone D 343081 Drug sensitive
2-Isopropenyl-4,6-diphenoxy-1,3,5-triazine 340916 Drug sensitive
4-Selenazolecarboxamide, 2-beta-D-ribofuranosyl- 334706 Drug sensitive
Phenyl gallate 333279 Drug sensitive
Zonarol 332671 Drug sensitive
Mercury, (p-carboxyphenyl)(purin-6-ylthio)- 3246339 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive
2-Hydroxy-4-((2,4,6-triamino-5-pyrimidinyl)diazenyl)phenylarsonic acid 272658 Drug sensitive
Digoxin 2724385 Drug sensitive
(15S)-15-Ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one 2724040 Drug sensitive
3,6-Dibromophenanthrene-9,10-dione 258450 Drug sensitive
3-[(1R)-1-(2-Chlorophenyl)ethoxy]-5-{6-[(2S)-2,3-dihydroxypropoxy]-1H-1,3-benzodiazol-1-yl}thiophene-2-carboxamide 25263120 Drug sensitive
3-[(2-Chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide 25263092 Drug sensitive
2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(methylamino)ethyl]-1H-imidazo[4,5-c]pyridine-7-carboxamide 25023715 Drug resistant
1-(3-Bromo-phenyl)-3-(pyridin-2-ylsulfanyl)-propenone 24203485 Drug sensitive
2-[4-(Methoxy)phenyltio]-3-phenyl-5,7-diamino quinoxaline 24203447 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug sensitive
[(1R,2S,4R,6R,7R,10S,11R,14S,16S)-16-Hydroxy-7,11-dimethyl-6-(6-oxopyran-3-yl)-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-14-yl] acetate 23618199 Drug sensitive
(1S,2R,5Z,10R,11S,12R,16S)-2-Hydroxy-2,6,10-trimethyl-15-methylidene-13,18-dioxatricyclo[9.6.1.012,16]octadec-5-en-14-one 23425613 Drug sensitive
Scillirosidin, glycoside 222160 Drug sensitive
(1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug sensitive
8-Hydroxyquinoline 1923 Drug sensitive
Sudan II 18386 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug sensitive
Arsenic trioxide 14888 Drug sensitive
Methyl 3,4-dichloro-5-nitro-2-furoate 147711 Drug sensitive
(5S,10S,13R,14S)-3-[3,4-Dihydroxy-6-methyl-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,14-dihydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde 146156945 Drug sensitive
Dtxsid30327893 138402823 Drug sensitive
Acid Alizarine Red B 135565636 Drug sensitive
6-Aryl-pyrazolo[3,4-b]pyridine analogue 23 135435015 Drug sensitive
(1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug sensitive
Methyl (1S,10R,11S,12S)-11-acetyloxy-12-ethyl-4-[(13R,15R,17R)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 133126830 Drug sensitive
Actinomycin D, 93% 131954673 Drug sensitive
Dibutyltin dichloride 12688 Drug sensitive
Triphenyltin chloride 12540 Drug sensitive
Berberine chloride 12456 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Benzyl trisulfide 122842 Drug sensitive
Homovinblastine methanesulfonate salt 11970002 Drug sensitive
Melampodinin 11953936 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
Neoambrosin 11128594 Drug sensitive
p-Toluquinone 11122 Drug sensitive
Unii-9JU14BJ5QG 109374088 Drug sensitive
Capri Blue 102162 Drug sensitive
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive
Chimaphilin 101211 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
(1s,2e,4r,7e,11e)-4-hydroxy-2,7,11-cembratrien-6-one - Drug sensitive
(1s,2e,4s,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive
(E)-2-(2-(benzo[d][1,3]dioxol-5-yl)vinyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazole - Drug sensitive
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
1,2-benzisothiazoline-3-thione, 2-methyl- (8ci) - Drug sensitive
1,3,5-triazin-2-amine, 4,6-dimethoxy-n-phenyl- - Drug sensitive
1,3-isoquinolinedione, 4-[(3,4-dimethoxyphenyl)methylene]- - Drug sensitive
1,6,7,8-tetra-o-phenylcarbamoylcastnospermine - Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(3-chlorophenyl)-5-methyl- - Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive
2-(4-(methylsulfonyl)phenyl)-6-p-tolyl-4,5-dihydropyridazin-3(2H)-one - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
2k2S,S? - Drug sensitive
3,19-(2,6-dimethyoxy)benzylidineandrographolide - Drug sensitive
3,19-(4-n,n-dimethylamino)benzylidineandrographolide - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive
5-[2-(4-methoxyphenyl)ethyl]-1,2,3-dimethoxy benzene - Drug sensitive
5-chloro-1-(7-chloro-3-methyl-1,4-dioxyquinoxalin-2-yl)-5-(3,4,5-trimethoxy)-penta-2,4-dien-1-one - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-phenyl- - Drug sensitive
aceanthryleno[1,2-b]quinoxaline, 12-nitro- - Drug sensitive
aquatris(1,3-diphenylpropane-1,3-dionato)neodymium(iii) - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
c4, carbonyl, ethyl prodigiosine - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive
inosine, 6-thio-, 2',3',5'-tris(4-methoxybenzoate) - Drug sensitive
l-cysteine, s-[(4-methylphenyl)diphenylmethyl]- (9ci) - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
phosphonium, 1,8-octanediylbis[triphenyl-, diiodide - Drug sensitive
piceatannol, 4,3',5'-trimethyl,1s0 - Drug sensitive
piperazine-2,2,5,5-tetracarbonitrile, 3,6-dipropyl- - Drug sensitive
purine, 2,6,8-tris(hexylamino)- - Drug sensitive
roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive
thiazolo[3,2-f]phenanthridinium, 3-phenyl- perchlorate - Drug sensitive
urea, n'-(5,6-dichloro-1h-benzimidazol-2-yl)-n,n-dimethyl- - Drug sensitive
(s)(-)-methyl perillate - Drug sensitive
(Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug sensitive
2-oxo-N-(pyridin-4-yl)-2-(1-tosyl-1H-indol-3-yl)acetamide - Drug sensitive
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive
5-methoxy camptothecin - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
antineoplastic-644916 - Drug sensitive
Copper(II) complex with a thiosemicarbazone as a ligand - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
his 47-methyl ct - Drug sensitive
methyl 3-farnesylthioacetate - Drug sensitive
n-acetyl-4-s-cystaminyl phenol - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
phenylmercuric acetate (usan) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-505-3p
D-Glucose 5793 Drug interaction    RC00005735
Sunitinib 5329102 Drug interaction    RC00005738
Doxorubicin 31703 Drug interaction    RC00005736
Verapamil 2520 Drug interaction    RC00005734
Gefitinib 123631 Drug interaction    RC00005737
Chemotherapy - Drug interaction    RC00008872

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-505-3p
Interactor2: PRRSVgp4

Evidence Support:


Strong-Evidence RISC-IP//RT-PCR
Support Database VmiReg

References:


PMID 24503081 Target region None
Source VmiReg Interactor1 expression None
Tissue or cell line CRL-2843 cells Interactor2 expression None
Description Different type 2 PRRSV strains harbored conserved miR-23, miR-378, and miR-505 target sites (TSs) that were sufficient to confer miRNA-mediated repression of PRRSV replication. miR-23, miR-378, and miR-505 suppressed PRRSV replication by directly targeting its genomic and subgenomic RNAs.

Starting a new search, please wait ...