Detail Information

Basic Information:


  VIRBase ID:  

HVID00000003

  Virus:  

Porcine reproductive and respiratory syndrome virus (PRRSV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-23a-3p PRRSVgp4
miRBase
Accession/Entrez ID		 MIMAT0000078 1494891
Organism Homo sapiens Porcine reproductive and respiratory syndrome virus (PRRSV)
Category miRNA mRNA
Alias - PRRSVgp4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-23a-3p
rs755278286 chr19:13836597    A/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-23a-3p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome LAC cell line (A549)     27492069
Exosome Saliva     19627513
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Ovarian follicular fluid     22116803
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-23a-3p
Ternatin 5459184 Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-23a-3p
Curcumin 969516 Drug interaction    RC00000694
Formaldehyde 712 Drug interaction    RC00000675
AICA ribonucleotide 65110 Drug interaction    RC00000690
Medroxyprogesterone acetate 6279 Drug interaction    RC00000685
Irinotecan 60838 Drug interaction    RC00000689
Phenylephrine 6041 Drug interaction    RC00000684
Vincristine 5978 Drug interaction    RC00000683
Estradiol 5757 Drug interaction    RC00000682
Mitomycin 5746 Drug interaction    RC00000681
Dexamethasone 5743 Drug interaction    RC00000680
Eloxatine 5310940 Drug interaction    RC00000697
Morphine 5288826 Drug interaction    RC00000696
Diethylstilbestrol 448537 Drug interaction    RC00000693
Metformin 4091 Drug interaction    RC00000679
Carboplatinum 38904 Drug interaction    RC00000688
Etoposide 36462 Drug interaction    RC00000687
5-Fluorouracil 3385 Drug interaction    RC00000678
Enoxacin 3229 Drug interaction    RC00000677
Doxorubicin 31703 Drug interaction    RC00000686
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000676
Tamoxifen 2733526 Drug interaction    RC00000695
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00000698
Gefitinib 123631 Drug interaction    RC00000692
1'-Acetoxychavicol acetate 119104 Drug interaction    RC00000691
modified ALLIC BFM 2002 protocol - Drug interaction    RC00000699
Bio-Oss - Drug interaction    RC00000700
Essential amino acids (EAA) - Drug interaction    RC00000701
Trastuzumab - Drug interaction    RC00000702
Chemotherapy - Drug interaction    RC00008820
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-23a-3p
Cisplatin 5702198       25356050
Cisplatin 5702198       26676926
Sirolimus 5284616       31063487
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-23a-3p
Interactor2: PRRSVgp4

Evidence Support:


Strong-Evidence RISC-IP//RT-PCR
Support Database VmiReg

References:


PMID 24503081 Target region None
Source VmiReg Interactor1 expression None
Tissue or cell line CRL-2843 cells//Marc-145 cells Interactor2 expression None
Description Different type 2 PRRSV strains harbored conserved miR-23, miR-378, and miR-505 target sites (TSs) that were sufficient to confer miRNA-mediated repression of PRRSV replication. miR-23, miR-378, and miR-505 suppressed PRRSV replication by directly targeting its genomic and subgenomic RNAs.

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