Basic Information:

  VIRBase ID:  

HHID00109422

  Virus:  

Severe acute respiratory syndrome-related coronavirus (SARS)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-323a-3p:  MIMAT0000755          SMAD3:  NM_005902     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-323a-3p	SMAD3
miRBase Accession/Entrez ID	MIMAT0000755	4088
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSPC193//HsT17436//JV15-2//LDS1C//LDS3//MADH3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-323a-3p	rs1027221425 chr14:101025796    G/A rs754169604 chr14:101025795    C/A rs754169604 chr14:101025795    C/T rs760090907 chr14:101025792    G/A rs760090907 chr14:101025792    G/C rs760795068 chr14:101025790    A/G rs766635782 chr14:101025791    C/T rs376870645 chr14:101025783    A/C rs376870645 chr14:101025783    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SMAD3	chr15:67452930(+) A-I      intronic chr15:67452962(+) A-I      intronic chr15:67358882(+) A-I      intronic chr15:67451670(+) A-I      intronic chr15:67451671(+) A-I      intronic chr15:67452947(+) A-I      intronic chr15:67394254(+) A-I      intronic chr15:67451683(+) A-I      intronic chr15:67451672(+) A-I      intronic chr15:67452950(+) A-I      intronic chr15:67394253(+) A-I      intronic chr15:67362173(+) A-I      intronic chr15:67403460(+) A-I      intronic chr15:67451592(+) A-I      intronic chr15:67451581(+) A-I      intronic chr15:67451570(+) A-I      intronic chr15:67416609(+) A-I      intronic chr15:67416603(+) A-I      intronic chr15:67416411(+) A-I      intronic chr15:67416365(+) A-I      intronic chr15:67416349(+) A-I      intronic chr15:67415758(+) A-I      intronic chr15:67389768(+) A-I      intronic chr15:67389769(+) A-I      intronic chr15:67415506(+) A-I      intronic chr15:67415445(+) A-I      intronic chr15:67415389(+) A-I      intronic chr15:67367127(+) A-I      intronic chr15:67452943(+) A-I      intronic chr15:67456585(+) A-I      intronic chr15:67412396(+) A-I      intronic chr15:67456466(+) A-I      intronic chr15:67389771(+) A-I      intronic chr15:67368181(+) A-I      intronic chr15:67456616(+) A-I      intronic chr15:67456372(+) A-I      intronic chr15:67412356(+) A-I      intronic chr15:67456581(+) A-I      intronic chr15:67405627(+) A-I      intronic chr15:67366170(+) A-I      intronic chr15:67456546(+) A-I      intronic chr15:67392319(+) A-I      intronic chr15:67412179(+) A-I      intronic chr15:67456542(+) A-I      intronic chr15:67456516(+) A-I      intronic chr15:67456471(+) A-I      intronic chr15:67456470(+) A-I      intronic chr15:67368088(+) A-I      intronic chr15:67366112(+) A-I      intronic chr15:67389693(+) A-I      intronic chr15:67367131(+) A-I      intronic chr15:67367102(+) A-I      intronic chr15:67367157(+) A-I      intronic chr15:67455501(+) A-I      intronic chr15:67366211(+) A-I      intronic chr15:67366195(+) A-I      intronic chr15:67366149(+) A-I      intronic chr15:67366142(+) A-I      intronic chr15:67366113(+) A-I      intronic chr15:67410310(+) A-I      intronic chr15:67455495(+) A-I      intronic chr15:67368114(+) A-I      intronic chr15:67455405(+) A-I      intronic chr15:67455376(+) A-I      intronic chr15:67453054(+) A-I      intronic chr15:67412228(+) A-I      intronic chr15:67453053(+) A-I      intronic chr15:67453034(+) A-I      intronic chr15:67453018(+) A-I      intronic chr15:67415675(+) A-I      intronic chr15:67368202(+) A-I      intronic chr15:67366106(+) A-I      intronic chr15:67366069(+) A-I      intronic chr15:67366061(+) A-I      intronic chr15:67453015(+) A-I      intronic chr15:67415386(+) A-I      intronic chr15:67453011(+) A-I      intronic chr15:67452994(+) A-I      intronic chr15:67452958(+) A-I      intronic chr15:67452927(+) A-I      intronic chr15:67452894(+) A-I      intronic chr15:67452891(+) A-I      intronic chr15:67452855(+) A-I      intronic chr15:67452839(+) A-I      intronic chr15:67415717(+) A-I      intronic chr15:67451509(+) A-I      intronic chr15:67451652(+) A-I      intronic chr15:67451609(+) A-I      intronic chr15:67451606(+) A-I      intronic chr15:67456143(+) A-I      intronic chr15:67410283(+) A-I      intronic chr15:67412332(+) A-I      intronic chr15:67451478(+) A-I      intronic chr15:67412397(+) A-I      intronic chr15:67367047(+) A-I      intronic chr15:67368106(+) A-I      intronic chr15:67363921(+) A-I      intronic chr15:67455555(+) A-I      intronic chr15:67416500(+) A-I      intronic chr15:67455512(+) A-I      intronic chr15:67367189(+) A-I      intronic chr15:67415375(+) A-I      intronic chr15:67415739(+) A-I      intronic chr15:67415579(+) A-I      intronic chr15:67443457(+) A-I      intronic chr15:67415685(+) A-I      intronic chr15:67368133(+) A-I      intronic chr15:67368119(+) A-I      intronic chr15:67452882(+) A-I      intronic chr15:67368174(+) A-I      intronic chr15:67367193(+) A-I      intronic chr15:67416427(+) A-I      intronic chr15:67366220(+) A-I      intronic chr15:67416492(+) A-I      intronic chr15:67362144(+) A-I      intronic chr15:67367097(+) A-I      intronic chr15:67476581(+) A-I      intronic chr15:67368185(+) A-I      intronic chr15:67415373(+) A-I      intronic chr15:67415687(+) A-I      intronic chr15:67410410(+) A-I      intronic chr15:67362114(+) A-I      intronic chr15:67421012(+) A-I      intronic chr15:67410364(+) A-I      intronic chr15:67455333(+) A-I      intronic chr15:67368100(+) A-I      intronic chr15:67416601(+) A-I      intronic chr15:67410351(+) A-I      intronic chr15:67452978(+) A-I      intronic chr15:67415787(+) A-I      intronic chr15:67405710(+) A-I      intronic chr15:67455441(+) A-I      intronic chr15:67366158(+) A-I      intronic chr15:67368198(+) A-I      intronic chr15:67455332(+) A-I      intronic chr15:67368203(+) A-I      intronic chr15:67363962(+) A-I      intronic chr15:67415671(+) A-I      intronic chr15:67415676(+) A-I      intronic chr15:67405711(+) A-I      intronic chr15:67405702(+) A-I      intronic chr15:67368210(+) A-I      intronic chr15:67416395(+) A-I      intronic chr15:67416561(+) A-I      intronic chr15:67415408(+) A-I      intronic chr15:67415680(+) A-I      intronic chr15:67368146(+) A-I      intronic chr15:67410342(+) A-I      intronic chr15:67416562(+) A-I      intronic chr15:67456395(+) A-I      intronic chr15:67362119(+) A-I      intronic chr15:67478497(+) A-I      intronic chr15:67368044(+) A-I      intronic chr15:67452949(+) A-I      intronic chr15:67363875(+) A-I      intronic chr15:67483483(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SMAD3	chr15:67368146(+) A-G intron -    22484847 chr15:67415675(+) A-G intron -    22484847 chr15:67451478(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SMAD3	chr15:67356224-67356225(+) m6A 5'UTR       24981863 chr15:67356275-67356276(+) m6A 5'UTR       24981863 chr15:67358549-67358550(+) m1A CDS//intron       26863196//26863410 chr15:67358614-67358615(+) m6A CDS//intron       24284625//24981863//26404942 chr15:67390932-67390933(+) m6A 5'UTR//intron       24284625 chr15:67418223-67418224(+) m6A 5'UTR//intron       24981863 chr15:67457312-67457313(+) m6A 5'UTR//CDS//exon       24284625 chr15:67457419-67457420(+) m6A CDS//exon       24284625//24981863 chr15:67457677-67457678(+) m6A CDS//exon       24284625//24981863 chr15:67459093-67459094(+) m6A 5'UTR//intron       24284625//24981863 chr15:67459118-67459119(+) m6A 5'UTR//CDS//exon       24284625//24981863 chr15:67459154-67459155(+) m6A 5'UTR//CDS//exon       24284625//24981863//26404942 chr15:67459173-67459174(+) m6A CDS//exon       24284625//24981863//26404942 chr15:67462900-67462901(+) m6A CDS//exon       24284625//24981863//26404942 chr15:67462971-67462972(+) m6A exon//intron       24284625//24981863 chr15:67466703-67466704(+) m6A exon//intron       24284625 chr15:67466805-67466806(+) m6A exon//intron       24284625 chr15:67473784-67473785(+) Cm CDS//intron       - chr15:67482753-67482754(+) m6A CDS//exon//intron       24284625//24209618//24981863 chr15:67482876-67482877(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr15:67482943-67482944(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483023-67483024(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483035-67483036(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483056-67483057(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483073-67483074(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483144-67483145(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483180-67483181(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483229-67483230(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483246-67483247(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483310-67483311(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483358-67483359(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483405-67483406(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483430-67483431(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483480-67483481(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483512-67483513(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483525-67483526(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483562-67483563(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483916-67483917(+) m6A 3'UTR//intron       24284625//24981863 chr15:67483927-67483928(+) m6A 3'UTR//intron       24284625//24981863 chr15:67484050-67484051(+) m6A 3'UTR//intron       26404942 chr15:67484252-67484253(+) m6A 3'UTR//intron       24209618//24981863//26404942 chr15:67484320-67484321(+) m6A 3'UTR//intron       24209618//24981863//26404942 chr15:67484329-67484330(+) m6A 3'UTR//intron       24981863//26404942 chr15:67484334-67484335(+) m6A 3'UTR//intron       24981863//26404942 chr15:67484616-67484617(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr15:67484642-67484643(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484675-67484676(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484712-67484713(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484720-67484721(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484730-67484731(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484830-67484831(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr15:67484870-67484871(+) m6A 3'UTR//intron       24284625//24209618 chr15:67484878-67484879(+) m6A 3'UTR//intron       24284625//24209618 chr15:67485027-67485028(+) m6A 3'UTR//intron       24981863 chr15:67485134-67485135(+) m6A 3'UTR//intron       24981863//26404942 chr15:67485187-67485188(+) m6A 3'UTR//intron       24981863//26404942 chr15:67485202-67485203(+) m6A 3'UTR//intron       24981863//26404942 chr15:67485289-67485290(+) m6A 3'UTR//exon       26404942 chr15:67485323-67485324(+) m6A 3'UTR//exon       26404942 chr15:67485510-67485511(+) m6A 3'UTR//exon       26404942 chr15:67485525-67485526(+) m6A 3'UTR       26404942 chr15:67485548-67485549(+) m6A 3'UTR       26404942 chr15:67485684-67485685(+) m6A 3'UTR       24981863 chr15:67485711-67485712(+) m6A 3'UTR       24981863 chr15:67485871-67485872(+) m6A 3'UTR       24284625 chr15:67485909-67485910(+) m6A 3'UTR       24284625 chr15:67485924-67485925(+) m6A 3'UTR       24284625 chr15:67485951-67485952(+) m6A 3'UTR       24284625 chr15:67486071-67486072(+) m6A 3'UTR       26404942 chr15:67486164-67486165(+) m6A 3'UTR       26404942 chr15:67486385-67486386(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085 chr15:67486439-67486440(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085 chr15:67486513-67486514(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486518-67486519(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486677-67486678(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr15:67486744-67486745(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr15:67486762-67486763(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr15:67486784-67486785(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr15:67486799-67486800(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr15:67486908-67486909(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486917-67486918(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486972-67486973(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22608085 chr15:67487053-67487054(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr15:67487060-67487061(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr15:67487074-67487075(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr15:67487094-67487095(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67487142-67487143(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67487253-67487254(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67487285-67487286(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-323a-3p	Exosome Serum     18589210 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Ovarian follicular fluid     22116803 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Cerebrospinal fluid     24797360 Microvesicle Blood|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	SMAD3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-323a-3p
Interactor2: SMAD3

Evidence Support:

Prediction-Evidence	miRTarBase//miRWalk
Support Database	ViRBase

References:

PMID	33475497	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Our data revealed that 709 miRNAs target these mRNAs, among which 145 functional MTIs were found and were subsequently selected as the most important interactions for further examination.