Detail Information

Basic Information:


  VIRBase ID:  

HHID00109409

  Virus:  

Severe acute respiratory syndrome-related coronavirus (SARS)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-206:           SMAD2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-206 SMAD2
miRBase
Accession/Entrez ID		 MIMAT0000462 4087
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - hMAD-2//hSMAD2//JV18//JV18-1//MADH2//MADR2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-206
rs1377769915 chr6:52144418    T/C
rs1444614734 chr6:52144412    G/C
rs529520481 chr6:52144422    G/T
rs761212265 chr6:52144417    G/T
rs764617948 chr6:52144414    A/C
rs767863130 chr6:52144401    T/A
rs767863130 chr6:52144401    T/C
rs775920179 chr6:52144406    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SMAD2
chr18:45411706(-) A-I      intronic
chr18:45408847(-) A-I      intronic
chr18:45408841(-) A-I      intronic
chr18:45363668(-) A-I      3'UTR
chr18:45411757(-) A-I      intronic
chr18:45411752(-) A-I      intronic
chr18:45451008(-) A-I      intronic
chr18:45363704(-) A-I      3'UTR
chr18:45450997(-) A-I      intronic
chr18:45439387(-) A-I      intronic
chr18:45437525(-) A-I      intronic
chr18:45363690(-) A-I      3'UTR
chr18:45363689(-) A-I      3'UTR
chr18:45363677(-) A-I      3'UTR
chr18:45379889(-) A-I      intronic
chr18:45411740(-) A-I      intronic
chr18:45408840(-) A-I      intronic
chr18:45411734(-) A-I      intronic
chr18:45411732(-) A-I      intronic
chr18:45411717(-) A-I      intronic
chr18:45411709(-) A-I      intronic
chr18:45363671(-) A-I      3'UTR
chr18:45451101(-) A-I      intronic
chr18:45439480(-) A-I      intronic
chr18:45439485(-) A-I      intronic
chr18:45439486(-) A-I      intronic
chr18:45439564(-) A-I      intronic
chr18:45450390(-) A-I      intronic
chr18:45450415(-) A-I      intronic
chr18:45450450(-) A-I      intronic
chr18:45450454(-) A-I      intronic
chr18:45450456(-) A-I      intronic
chr18:45450457(-) A-I      intronic
chr18:45450519(-) A-I      intronic
chr18:45386945(-) A-I      intronic
chr18:45450495(-) A-I      intronic
chr18:45387470(-) A-I      intronic
chr18:45387553(-) A-I      intronic
chr18:45387583(-) A-I      intronic
chr18:45387605(-) A-I      intronic
chr18:45387664(-) A-I      intronic
chr18:45387691(-) A-I      intronic
chr18:45399317(-) A-I      intronic
chr18:45404949(-) A-I      intronic
chr18:45404959(-) A-I      intronic
chr18:45418735(-) A-I      intronic
chr18:45386445(-) A-I      intronic
chr18:45386450(-) A-I      intronic
chr18:45408795(-) A-I      intronic
chr18:45386382(-) A-I      intronic
chr18:45386378(-) A-I      intronic
chr18:45386315(-) A-I      intronic
chr18:45408682(-) A-I      intronic
chr18:45408763(-) A-I      intronic
chr18:45408764(-) A-I      intronic
chr18:45408819(-) A-I      intronic
chr18:45411604(-) A-I      intronic
chr18:45411639(-) A-I      intronic
chr18:45411703(-) A-I      intronic
chr18:45411771(-) A-I      intronic
chr18:45412098(-) A-I      intronic
chr18:45412128(-) A-I      intronic
chr18:45412129(-) A-I      intronic
chr18:45412135(-) A-I      intronic
chr18:45386926(-) A-I      intronic
chr18:45412141(-) A-I      intronic
chr18:45412150(-) A-I      intronic
chr18:45417593(-) A-I      intronic
chr18:45386759(-) A-I      intronic
chr18:45386867(-) A-I      intronic
chr18:45386479(-) A-I      intronic
chr18:45386496(-) A-I      intronic
chr18:45386758(-) A-I      intronic
chr18:45386384(-) A-I      intronic
chr18:45451107(-) A-I      intronic
chr18:45405342(-) A-I      intronic
chr18:45450536(-) A-I      intronic
chr18:45417594(-) A-I      intronic
chr18:45439363(-) A-I      intronic
chr18:45439428(-) A-I      intronic
chr18:45450363(-) A-I      intronic
chr18:45408463(-) A-I      intronic
chr18:45417671(-) A-I      intronic
chr18:45411733(-) A-I      intronic
chr18:45411614(-) A-I      intronic
chr18:45386940(-) A-I      intronic
chr18:45411811(-) A-I      intronic
chr18:45386873(-) A-I      intronic
chr18:45412115(-) A-I      intronic
chr18:45434140(-) A-I      intronic
chr18:45450956(-) A-I      intronic
chr18:45450971(-) A-I      intronic
chr18:45386421(-) A-I      intronic
chr18:45386735(-) A-I      intronic
chr18:45386499(-) A-I      intronic
chr18:45386431(-) A-I      intronic
chr18:45386803(-) A-I      intronic
chr18:45417431(-) A-I      intronic
chr18:45411653(-) A-I      intronic
chr18:45386913(-) A-I      intronic
chr18:45450437(-) A-I      intronic
chr18:45404918(-) A-I      intronic
chr18:45450451(-) A-I      intronic
chr18:45386491(-) A-I      intronic
chr18:45404820(-) A-I      intronic
chr18:45382090(-) A-I      intronic
chr18:45451011(-) A-I      intronic
chr18:45382004(-) A-I      intronic
chr18:45418744(-) A-I      intronic
chr18:45405391(-) A-I      intronic
chr18:45386745(-) A-I      intronic
chr18:45412271(-) A-I      intronic
chr18:45450376(-) A-I      intronic
chr18:45386438(-) A-I      intronic
chr18:45450929(-) A-I      intronic
chr18:45418770(-) A-I      intronic
chr18:45386807(-) A-I      intronic
chr18:45450890(-) A-I      intronic
chr18:45418663(-) A-I      intronic
chr18:45450905(-) A-I      intronic
chr18:45417419(-) A-I      intronic
chr18:45412184(-) A-I      intronic
chr18:45418739(-) A-I      intronic
chr18:45411776(-) A-I      intronic
chr18:45450503(-) A-I      intronic
chr18:45386905(-) A-I      intronic
chr18:45386406(-) A-I      intronic
chr18:45386927(-) A-I      intronic
chr18:45418817(-) A-I      intronic
chr18:45451060(-) A-I      intronic
chr18:45408472(-) A-I      intronic
chr18:45412270(-) A-I      intronic
chr18:45386866(-) A-I      intronic
chr18:45386862(-) A-I      intronic
chr18:45450533(-) A-I      intronic
chr18:45451000(-) A-I      intronic
chr18:45417564(-) A-I      intronic
chr18:45434151(-) A-I      intronic
chr18:45408508(-) A-I      intronic
chr18:45450375(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SMAD2
chr18:45386491(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SMAD2
chr18:45335476-45335477(-) m6A 3'UTR       -
chr18:45335507-45335508(-) m6A 3'UTR       -
chr18:45335581-45335582(-) m6A 3'UTR       -
chr18:45335617-45335618(-) m6A 3'UTR       -
chr18:45335626-45335627(-) m6A 3'UTR       -
chr18:45335655-45335656(-) m6A 3'UTR       -
chr18:45335703-45335704(-) m6A 3'UTR       -
chr18:45367936-45367937(-) m6A 3'UTR       24981863//27773535
chr18:45367963-45367964(-) m6A 3'UTR       24981863//27773535//22608085
chr18:45368087-45368088(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr18:45368119-45368120(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr18:45368168-45368169(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr18:45368252-45368253(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:45368269-45368270(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:45368284-45368285(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:45379653-45379654(-) m6A intron       27773535//22608085
chr18:45379658-45379659(-) m6A intron       27773535//22608085
chr18:45379683-45379684(-) m6A intron       27773535//22608085
chr18:45394740-45394741(-) m6A CDS//exon       24284625
chr18:45394781-45394782(-) m6A CDS//exon       24284625
chr18:45395619-45395620(-) m6A CDS//exon       24284625
chr18:45396893-45396894(-) Tm CDS//exon//intron       -
chr18:45396913-45396914(-) m6A CDS//exon//intron       27773535
chr18:45421644-45421645(-) m6A exon//intron       27773535
chr18:45422921-45422922(-) m6A CDS       25456834//24981863//27773535//27371828//22608085
chr18:45422964-45422965(-) m6A CDS       25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr18:45422976-45422977(-) m1A CDS       26863196
chr18:45423058-45423059(-) Tm CDS       -
chr18:45423069-45423070(-) m1A CDS       26863196
chr18:45423085-45423086(-) m6A CDS       25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr18:45423128-45423129(-) m6A 5'UTR       25456834//24981863//27773535//27371828//27773536//22575960
chr18:45446444-45446445(-) m6A 5'UTR//intron       27773535//22575960
chr18:45446460-45446461(-) m6A 5'UTR//intron       27773535//22575960
chr18:45456749-45456750(-) m6A 5'UTR//intron       24981863//27773536
chr18:45456773-45456774(-) m6A 5'UTR//intron       24981863//27371828//27773536
chr18:45456787-45456788(-) m6A 5'UTR//intron       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-206
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
SMAD2
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-206
Cholesterol 5997 Drug interaction    RC00003325
Vorinostat 5311 Drug interaction    RC00003324
Eloxatine 5310940 Drug interaction    RC00003331
Paroxetine 43815 Drug interaction    RC00003329
Paclitaxel 36314 Drug interaction    RC00003328
5-Fluorouracil 3385 Drug interaction    RC00003323
Doxorubicin 31703 Drug interaction    RC00003327
Bromocriptine 31101 Drug interaction    RC00003326
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003322
Verapamil 2520 Drug interaction    RC00003321
Sorafenib 216239 Drug interaction    RC00003330
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-206
Irinotecan       60838
Topotecan       60700
Paclitaxel       36314
Sorafenib       216239
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-206
Interactor2: SMAD2

Evidence Support:


Prediction-Evidence miRTarBase//miRWalk
Support Database ViRBase

References:


PMID 33475497 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Our data revealed that 709 miRNAs target these mRNAs, among which 145 functional MTIs were found and were subsequently selected as the most important interactions for further examination.

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