Detail Information

Basic Information:


  VIRBase ID:  

HHID00109360

  Virus:  

Severe acute respiratory syndrome-related coronavirus (SARS)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:           SMAD4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-182-5p SMAD4
miRBase
Accession/Entrez ID		 MIMAT0000259 4089
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DPC4//JIP//MADH4//MYHRS

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-182-5p
rs1164249188 chr7:129770446    CA/C
rs1232455061 chr7:129770449    T/G
rs1303310695 chr7:129770447    A/C
rs1331665171 chr7:129770448    G/A
rs750597507 chr7:129770453    A/G
rs760187044 chr7:129770452    G/A
rs765932794 chr7:129770462    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SMAD4
chr18:48578306(+) A-I      intronic
chr18:48578316(+) A-I      intronic
chr18:48600534(+) A-I      intronic
chr18:48565383(+) A-I      intronic
chr18:48600546(+) A-I      intronic
chr18:48565420(+) A-I      intronic
chr18:48565430(+) A-I      intronic
chr18:48600660(+) A-I      intronic
chr18:48600620(+) A-I      intronic
chr18:48600584(+) A-I      intronic
chr18:48600566(+) A-I      intronic
chr18:48600515(+) A-I      intronic
chr18:48600494(+) A-I      intronic
chr18:48600161(+) A-I      intronic
chr18:48600119(+) A-I      intronic
chr18:48600067(+) A-I      intronic
chr18:48570615(+) A-I      intronic
chr18:48565362(+) A-I      intronic
chr18:48600066(+) A-I      intronic
chr18:48595694(+) A-I      intronic
chr18:48595551(+) A-I      intronic
chr18:48595530(+) A-I      intronic
chr18:48570618(+) A-I      intronic
chr18:48593847(+) A-I      intronic
chr18:48595195(+) A-I      intronic
chr18:48595225(+) A-I      intronic
chr18:48595093(+) A-I      intronic
chr18:48562405(+) A-I      intronic
chr18:48595535(+) A-I      intronic
chr18:48568917(+) A-I      intronic
chr18:48595180(+) A-I      intronic
chr18:48563434(+) A-I      intronic
chr18:48595170(+) A-I      intronic
chr18:48600703(+) A-I      intronic
chr18:48600081(+) A-I      intronic
chr18:48595087(+) A-I      intronic
chr18:48562381(+) A-I      intronic
chr18:48570614(+) A-I      intronic
chr18:48595746(+) A-I      intronic
chr18:48600630(+) A-I      intronic
chr18:48595261(+) A-I      intronic
chr18:48600580(+) A-I      intronic
chr18:48595737(+) A-I      intronic
chr18:48600601(+) A-I      intronic
chr18:48595733(+) A-I      intronic
chr18:48600486(+) A-I      intronic
chr18:48565357(+) A-I      intronic
chr18:48607095(+) A-I      3'UTR
chr18:48593963(+) A-I      intronic
chr18:48600587(+) A-I      intronic
chr18:48568940(+) A-I      intronic
chr18:48568907(+) A-I      intronic
chr18:48595141(+) A-I      intronic
chr18:48595616(+) A-I      intronic
chr18:48563346(+) A-I      intronic
chr18:48600040(+) A-I      intronic
chr18:48600084(+) A-I      intronic
chr18:48562477(+) A-I      intronic
chr18:48568854(+) A-I      intronic
chr18:48600510(+) A-I      intronic
chr18:48561789(+) A-I      intronic
chr18:48570546(+) A-I      intronic
chr18:48563433(+) A-I      intronic
chr18:48600585(+) A-I      intronic
chr18:48595628(+) A-I      intronic
chr18:48595626(+) A-I      intronic
chr18:48600567(+) A-I      intronic
chr18:48595266(+) A-I      intronic
chr18:48595682(+) A-I      intronic
chr18:48593863(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SMAD4
chr18:48570896(+) A-I intron -    21960545
chr18:48600040(+) A-I intron -    21960545
chr18:48565356(+) A-G intron -    22484847
chr18:48565357(+) A-G intron -    22484847
chr18:48595087(+) A-G intron -    22484847
chr18:48600486(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SMAD4
chr18:48556546-48556547(+) m6A 5'UTR//intron       24981863
chr18:48573383-48573384(+) m6A 5'UTR//intron       24284625//24981863//26404942//22608085
chr18:48573406-48573407(+) m6A 5'UTR//intron       24284625//24981863//26404942//22608085
chr18:48573412-48573413(+) m6A 5'UTR//intron       24284625//24981863//26404942//22608085
chr18:48573420-48573421(+) m6A CDS//intron       24284625//24981863//26404942//22608085
chr18:48573496-48573497(+) m6A CDS//intron       24284625//24981863//26404942//22608085
chr18:48573515-48573516(+) m6A CDS//intron       24284625//24981863//26404942//22608085
chr18:48581199-48581200(+) m6A CDS//exon       -
chr18:48581223-48581224(+) m6A CDS//exon       -
chr18:48581236-48581237(+) m6A CDS//exon       -
chr18:48581275-48581276(+) m6A CDS//exon       -
chr18:48584534-48584535(+) m6A CDS//exon//intron       -
chr18:48584567-48584568(+) m6A CDS//exon//intron       -
chr18:48584726-48584727(+) m6A CDS//exon//intron       24981863
chr18:48584738-48584739(+) m6A CDS//exon//intron       24284625//24981863
chr18:48584818-48584819(+) m6A CDS//exon//intron       24284625//24981863
chr18:48591912-48591913(+) Gm CDS//exon//intron       -
chr18:48604707-48604708(+) m6A 3'UTR//CDS//exon       24981863//22608085
chr18:48604722-48604723(+) m6A 3'UTR//CDS//exon       24981863//22608085
chr18:48604738-48604739(+) m6A 3'UTR//CDS//exon       24981863//22608085
chr18:48604817-48604818(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085
chr18:48604832-48604833(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085
chr18:48604879-48604880(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22608085
chr18:48604986-48604987(+) m6A 3'UTR//exon       24981863//22608085
chr18:48604992-48604993(+) m6A 3'UTR//exon       24981863//22608085
chr18:48605003-48605004(+) m6A 3'UTR//exon       24981863//22608085
chr18:48605027-48605028(+) m6A 3'UTR//exon       24981863//22608085
chr18:48605053-48605054(+) Am 3'UTR//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-182-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097
Exosome Human milk     28688106
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
SMAD4
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-182-5p
Sensorad 99342 Drug sensitive
N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive
Ixabepilone 6445540 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Tiazofurin 457954 Drug sensitive
Antineoplastic-645804 371505 Drug sensitive
(4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive
Predorine 333830 Drug sensitive
4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive
Nile Blue 2B 20520 Drug sensitive
5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-182-5p
Hyaluronidase 91820602 Drug interaction    RC00001904
Formaldehyde 712 Drug interaction    RC00001887
Ethanol 702 Drug interaction    RC00001886
Atorvastatin 60823 Drug interaction    RC00001897
D-Glucose 5793 Drug interaction    RC00001894
Temozolomide 5394 Drug interaction    RC00001893
Vorinostat 5311 Drug interaction    RC00001892
Eloxatine 5310940 Drug interaction    RC00001902
Decitabine 451668 Drug interaction    RC00001900
Trichostatin A 444732 Drug interaction    RC00001899
Paclitaxel 36314 Drug interaction    RC00001896
5-Fluorouracil 3385 Drug interaction    RC00001891
Fentanyl 3345 Drug interaction    RC00001890
Doxorubicin 31703 Drug interaction    RC00001895
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889
Tamoxifen 2733526 Drug interaction    RC00001901
Verapamil 2520 Drug interaction    RC00001888
Olaparib 23725625 Drug interaction    RC00001903
Aldesleukin - Drug interaction    RC00001905
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908
Marine fungal metabolite 1386A - Drug interaction    RC00001909
Chemotherapy - Drug interaction    RC00008834
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-182-5p
Tamoxifen 2733526       31153828
Veliparib 11960529       31063487
Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-182-5p
Interactor2: SMAD4

Evidence Support:


Prediction-Evidence miRTarBase//miRWalk
Support Database ViRBase

References:


PMID 33475497 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Our data revealed that 709 miRNAs target these mRNAs, among which 145 functional MTIs were found and were subsequently selected as the most important interactions for further examination.

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