Detail Information

Basic Information:


  VIRBase ID:  

HHID00109355

  Virus:  

Severe acute respiratory syndrome-related coronavirus (SARS)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-34a-5p RP11-867G23.10
miRBase
Accession/Entrez ID		 MIMAT0000255 RP11-867G23.10
Organism Homo sapiens Homo sapiens
Category miRNA lncRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-34a-5p
rs1230701086 chr1:9151742    G/T
rs35301225 chr1:9151743    C/A
rs35301225 chr1:9151743    C/T
rs750826817 chr1:9151744    T/A
rs768065817 chr1:9151739    C/T
rs1407488784 chr1:9151753    G/A
rs369892834 chr1:9151752    T/C
rs756492579 chr1:9151754    C/T
Resource Symbol SNP ID SNP Position Ref/Alt PMID
LincSNP 3.0 RP11-867G23.10
rs12785651 chr11:66411592 C/T         22233810
rs2282529 chr11:66416669 C/T         23388002
rs4466842 chr11:66415549 C/T         23722424
rs4930368 chr11:66411887 C/T         23722424
rs2282530 chr11:66410481 A/G         23722424
rs7935572 chr11:66416452 G/A         -

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RP11-867G23.10
chr11:66176926-66176927(+) m6A exon       25456834
chr11:66177340-66177341(+) m6A exon//intron       25456834
chr11:66177350-66177351(+) m6A exon//intron       25456834
chr11:66177380-66177381(+) m6A exon//intron       25456834
chr11:66177418-66177419(+) m6A exon//intron       25456834
chr11:66177461-66177462(+) m6A exon//intron       25456834
chr11:66177471-66177472(+) m6A exon//intron       25456834
chr11:66177648-66177649(+) m6A exon       25456834
chr11:66177706-66177707(+) m6A exon       25456834
chr11:66177728-66177729(+) m6A exon       25456834
chr11:66177741-66177742(+) m6A exon       25456834
chr11:66177829-66177830(+) m6A exon       24209618
chr11:66178194-66178195(+) m6A exon//intron       24209618
chr11:66178293-66178294(+) m6A exon//intron       25456834
chr11:66178307-66178308(+) m6A exon//intron       25456834
chr11:66178326-66178327(+) m6A exon       25456834
chr11:66178349-66178350(+) m6A exon       25456834
chr11:66178380-66178381(+) m6A exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-34a-5p
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome B lymphoblastoid cells     -
Extracellular vesicle Human mesenchymal stem cells     25669974
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle cells     27563705
Mitochondrion Human umbilical vein endothelial cells     30348904
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-34a-5p
Curcumin 969516 Drug resistant
3-Hydroxy-N-1-naphthyl-2-naphthamide 67241 Drug sensitive
Tacacoside A2 6712615 Drug sensitive
Cordycepin 6303 Drug resistant
Thapsia villosa compd 5477211 Drug resistant
5-(6-Methoxybenzimidazol-1-yl)-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide 53338692 Drug resistant
5-Iodo-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 45029271 Drug resistant
H-Cys(mmt)-OH 420454 Drug resistant
3-(3-Hydroxy-4-methoxybenzyl)-5,7-dihydroxychroman-4-one 404571 Drug resistant
(2S)-2,6-Diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide;methanesulfonic acid 399587 Drug sensitive
Antineoplastic-615804 355949 Drug resistant
Pyrazoloacridine 339455 Drug resistant
AT 116, benzylamine salt 282523 Drug resistant
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug resistant
5-(1H-1,3-Benzodiazol-1-yl)-3-[(2-bromophenyl)methoxy]thiophene-2-carboxamide 25263083 Drug resistant
Antimycin A3 245869 Drug sensitive
1-[1-(Diethylamino)propan-2-ylamino]-4-nitrothioxanthen-9-one;chloride 24186469 Drug sensitive
Nile Blue 2B 20520 Drug sensitive
1H-Indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 Drug sensitive
2-(naphthalen-2-yl)-1-(3,4,5-trimethoxyphenyl)-1h-imidazole - Drug resistant
2,2'-thienyl selenophenyl-5',2-thiophene - Drug resistant
3-piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]- - Drug resistant
6-Chloro-5-[2-(1H-imidazol-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one - Drug resistant
benzofuro[3,2-b]benzopyran-11-one, 3-hydroxy- - Drug resistant
l-cysteine, s-[(4-methylphenyl)diphenylmethyl]- (9ci) - Drug resistant
Paracymene-ruthenium(II)-[N-(3-(1H-imidazol-1-yl)propyl)-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8 tetrahydronaphthalen-2-yl)vinyl)benzamide] dichloride - Drug resistant
(-)-dactylolide - Drug resistant
2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug resistant
Basic Fuchsin - Drug resistant
organosulfur compound - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-34a-5p
Palmitic acid 985 Drug interaction    RC00001744
Curcumin 969516 Drug interaction    RC00001775
Formaldehyde 712 Drug interaction    RC00001743
Oxaliplatine 6857599 Drug interaction    RC00001784
Gemcitabine 60750 Drug interaction    RC00001763
Cholesterol 5997 Drug interaction    RC00001754
Vincristine 5978 Drug interaction    RC00001753
Prednisolone 5755 Drug interaction    RC00001752
Mitomycin 5746 Drug interaction    RC00001751
Doxycycline 54671203 Drug interaction    RC00001786
Sunitinib 5329102 Drug interaction    RC00001783
Vorinostat 5311 Drug interaction    RC00001750
Eloxatine 5310940 Drug interaction    RC00001782
delta-Tocotrienol 5282350 Drug interaction    RC00001781
Genistein 5280961 Drug interaction    RC00001780
Quercetin 5280343 Drug interaction    RC00001779
Decitabine 451668 Drug interaction    RC00001774
Diethylstilbestrol 448537 Drug interaction    RC00001773
Trichostatin A 444732 Drug interaction    RC00001772
Cyclopamine 442972 Drug interaction    RC00001771
Vemurafenib 42611257 Drug interaction    RC00001785
Etoposide 36462 Drug interaction    RC00001762
Paclitaxel 36314 Drug interaction    RC00001761
5-Fluorouracil 3385 Drug interaction    RC00001749
Emodin 3220 Drug interaction    RC00001748
Doxorubicin 31703 Drug interaction    RC00001760
Daunorubicin 30323 Drug interaction    RC00001759
Lithium 3028194 Drug interaction    RC00001778
Lithium ion 28486 Drug interaction    RC00001758
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001747
Tamoxifen 2733526 Drug interaction    RC00001777
Verapamil 2520 Drug interaction    RC00001746
Hyaluronan 24759 Drug interaction    RC00001757
Camptothecin 24360 Drug interaction    RC00001756
Benzene 241 Drug interaction    RC00001742
Aspirin 2244 Drug interaction    RC00001745
Lenalidomide 216326 Drug interaction    RC00001770
Sorafenib 216239 Drug interaction    RC00001769
Erlotinib 176870 Drug interaction    RC00001768
Capsaicin 1548943 Drug interaction    RC00001776
Arsenic trioxide 14888 Drug interaction    RC00001755
Docetaxel 148124 Drug interaction    RC00001767
Leucovorin 135403648 Drug interaction    RC00001787
Gefitinib 123631 Drug interaction    RC00001766
Paclitaxel + Cyclopamine - Drug interaction    RC00001795
platinum-based doublet chemotherapy - Drug interaction    RC00001788
TRAIL therapy - Drug interaction    RC00001789
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001790
Anthranilamide-pyrazolo[1,5-a]pyrimidine - Drug interaction    RC00001791
CDF(analogues of curcumin) - Drug interaction    RC00001792
Glucocorticoid - Drug interaction    RC00001793
Nicotinamide + Etoposide - Drug interaction    RC00001794
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-34a-5p
Cisplatin 5702198       27056900
Cisplatin 5702198       28073349
Cisplatin 5702198       28281638
Carboplatin 426756       27056900
Carboplatin 426756       28073349
Etoposide 36462       27056900
Etoposide 36462       28073349
Etoposide 36462       28281638
Doxorubicin 31703       27056900
Doxorubicin 31703       28073349
Doxorubicin 31703       28281638
Methotrexate 126941       27056900
Methotrexate 126941       28281638
Resource Symbol Drug Name PubChem ID
RNAactDrug RP11-867G23.10
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054
Tivozanib       9911830
Zibotentan       9910224
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
PI-103       9884685
Osi-930       9868037
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid       92577
(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one       78243717
N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473
(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848
Belinostat       6918638
Temsirolimus       6918289
Daporinad       6914657
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167
Tanespimycin       6505803
Ispinesib mesylate       6450816
Axitinib       6450551
Cytarabine       6253
Gemcitabine       60750
Mitomycin       5746
(2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)       57339144
1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea       56962337
Temozolomide       5394
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664
Vorinostat       5311
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396
Bis(2-hydroxy-1-naphthyl) disulfide       521106
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide       5113032
Tubastatin A       49850262
2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912
1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660
Tretinoin       444795
Dabrafenib       44462760
Foretinib       42642645
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide       42640
(2S)-2-[[2-(2,3-Dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol       42623900
Etoposide       36462
5-Fluorouracil       3385
Tamoxifen       2733526
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
Ruxolitinib       25126798
Cabozantinib       25102847
Navitoclax       24978538
Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314
Quizartinib       24889392
Ponatinib       24826799
Vismodegib       24776445
4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860
Cudc-101       24756910
Vincaleukoblastine       241903
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
Olaparib       23725625
Lenalidomide       216326
Lapatinib       208908
Enzastaurin       176167
4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388
Gsk-690693       16725726
Fedratinib       16722836
N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide       16095342
1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea       1401
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
Osi-027       135398516
Akt inhibitor VIII       135398501
Methotrexate       126941
Lestaurtinib       126565
Veliparib       11960529
BAY 61-3606 dihydrochloride       11784504
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511
Trametinib       11707110
4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725
Idelalisib       11625818
5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine       11617559
Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964
5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598
Linifanib       11485656
N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430
Amuvatinib       11282283
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667
7-Ethyl-10-hydroxycamptothecin       104842
VX-702       10341154
Afatinib       10184653
Selumetinib       10127622
N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147
Masitinib       10074640
Cisplatin       -
Genentech Cpd 10       -
JW-7-24-1       -
KIN001-236       -
KIN001-244       -
KIN001-260       -
KIN001-266       -
KIN001-270       -
MPS-1-IN-1       -
NPK76-II-72-1       -
Nutlin-3a (-)       -
QL-X-138       -
QL-XI-92       -
QL-XII-47       -
SB52334       -
THZ-2-102-1       -
TL-1-85       -
TL-2-105       -
VNLG/124       -
XMD13-2       -
XMD14-99       -
XMD15-27       -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-34a-5p
Interactor2: RP11-867G23.10

Evidence Support:


Prediction-Evidence miRTarBase//miRWalk
Support Database ViRBase

References:


PMID 33475497 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Our data revealed that 709 miRNAs target these mRNAs, among which 145 functional MTIs were found and were subsequently selected as the most important interactions for further examination.

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