Detail Information

Basic Information:


  VIRBase ID:  

HHID00109318

  Virus:  

Severe acute respiratory syndrome-related coronavirus (SARS)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol RP11-875O11.2 SMAD3
miRBase
Accession/Entrez ID		 RP11-875O11.2 4088
Organism Homo sapiens Homo sapiens
Category lncRNA mRNA
Alias - HSPC193//HsT17436//JV15-2//LDS1C//LDS3//MADH3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt PMID
LincSNP 3.0 RP11-875O11.2
rs4872049 chr8:23074266 C/T         20935629
rs11778166 chr8:23071837 C/T         20935629
rs4268128 chr8:23080343 C/T         21829388
rs28873480 chr8:23070798 C/T         24324551
rs57302454 chr8:23081148 G/C         24324551

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SMAD3
chr15:67452930(+) A-I      intronic
chr15:67452962(+) A-I      intronic
chr15:67358882(+) A-I      intronic
chr15:67451670(+) A-I      intronic
chr15:67451671(+) A-I      intronic
chr15:67452947(+) A-I      intronic
chr15:67394254(+) A-I      intronic
chr15:67451683(+) A-I      intronic
chr15:67451672(+) A-I      intronic
chr15:67452950(+) A-I      intronic
chr15:67394253(+) A-I      intronic
chr15:67362173(+) A-I      intronic
chr15:67403460(+) A-I      intronic
chr15:67451592(+) A-I      intronic
chr15:67451581(+) A-I      intronic
chr15:67451570(+) A-I      intronic
chr15:67416609(+) A-I      intronic
chr15:67416603(+) A-I      intronic
chr15:67416411(+) A-I      intronic
chr15:67416365(+) A-I      intronic
chr15:67416349(+) A-I      intronic
chr15:67415758(+) A-I      intronic
chr15:67389768(+) A-I      intronic
chr15:67389769(+) A-I      intronic
chr15:67415506(+) A-I      intronic
chr15:67415445(+) A-I      intronic
chr15:67415389(+) A-I      intronic
chr15:67367127(+) A-I      intronic
chr15:67452943(+) A-I      intronic
chr15:67456585(+) A-I      intronic
chr15:67412396(+) A-I      intronic
chr15:67456466(+) A-I      intronic
chr15:67389771(+) A-I      intronic
chr15:67368181(+) A-I      intronic
chr15:67456616(+) A-I      intronic
chr15:67456372(+) A-I      intronic
chr15:67412356(+) A-I      intronic
chr15:67456581(+) A-I      intronic
chr15:67405627(+) A-I      intronic
chr15:67366170(+) A-I      intronic
chr15:67456546(+) A-I      intronic
chr15:67392319(+) A-I      intronic
chr15:67412179(+) A-I      intronic
chr15:67456542(+) A-I      intronic
chr15:67456516(+) A-I      intronic
chr15:67456471(+) A-I      intronic
chr15:67456470(+) A-I      intronic
chr15:67368088(+) A-I      intronic
chr15:67366112(+) A-I      intronic
chr15:67389693(+) A-I      intronic
chr15:67367131(+) A-I      intronic
chr15:67367102(+) A-I      intronic
chr15:67367157(+) A-I      intronic
chr15:67455501(+) A-I      intronic
chr15:67366211(+) A-I      intronic
chr15:67366195(+) A-I      intronic
chr15:67366149(+) A-I      intronic
chr15:67366142(+) A-I      intronic
chr15:67366113(+) A-I      intronic
chr15:67410310(+) A-I      intronic
chr15:67455495(+) A-I      intronic
chr15:67368114(+) A-I      intronic
chr15:67455405(+) A-I      intronic
chr15:67455376(+) A-I      intronic
chr15:67453054(+) A-I      intronic
chr15:67412228(+) A-I      intronic
chr15:67453053(+) A-I      intronic
chr15:67453034(+) A-I      intronic
chr15:67453018(+) A-I      intronic
chr15:67415675(+) A-I      intronic
chr15:67368202(+) A-I      intronic
chr15:67366106(+) A-I      intronic
chr15:67366069(+) A-I      intronic
chr15:67366061(+) A-I      intronic
chr15:67453015(+) A-I      intronic
chr15:67415386(+) A-I      intronic
chr15:67453011(+) A-I      intronic
chr15:67452994(+) A-I      intronic
chr15:67452958(+) A-I      intronic
chr15:67452927(+) A-I      intronic
chr15:67452894(+) A-I      intronic
chr15:67452891(+) A-I      intronic
chr15:67452855(+) A-I      intronic
chr15:67452839(+) A-I      intronic
chr15:67415717(+) A-I      intronic
chr15:67451509(+) A-I      intronic
chr15:67451652(+) A-I      intronic
chr15:67451609(+) A-I      intronic
chr15:67451606(+) A-I      intronic
chr15:67456143(+) A-I      intronic
chr15:67410283(+) A-I      intronic
chr15:67412332(+) A-I      intronic
chr15:67451478(+) A-I      intronic
chr15:67412397(+) A-I      intronic
chr15:67367047(+) A-I      intronic
chr15:67368106(+) A-I      intronic
chr15:67363921(+) A-I      intronic
chr15:67455555(+) A-I      intronic
chr15:67416500(+) A-I      intronic
chr15:67455512(+) A-I      intronic
chr15:67367189(+) A-I      intronic
chr15:67415375(+) A-I      intronic
chr15:67415739(+) A-I      intronic
chr15:67415579(+) A-I      intronic
chr15:67443457(+) A-I      intronic
chr15:67415685(+) A-I      intronic
chr15:67368133(+) A-I      intronic
chr15:67368119(+) A-I      intronic
chr15:67452882(+) A-I      intronic
chr15:67368174(+) A-I      intronic
chr15:67367193(+) A-I      intronic
chr15:67416427(+) A-I      intronic
chr15:67366220(+) A-I      intronic
chr15:67416492(+) A-I      intronic
chr15:67362144(+) A-I      intronic
chr15:67367097(+) A-I      intronic
chr15:67476581(+) A-I      intronic
chr15:67368185(+) A-I      intronic
chr15:67415373(+) A-I      intronic
chr15:67415687(+) A-I      intronic
chr15:67410410(+) A-I      intronic
chr15:67362114(+) A-I      intronic
chr15:67421012(+) A-I      intronic
chr15:67410364(+) A-I      intronic
chr15:67455333(+) A-I      intronic
chr15:67368100(+) A-I      intronic
chr15:67416601(+) A-I      intronic
chr15:67410351(+) A-I      intronic
chr15:67452978(+) A-I      intronic
chr15:67415787(+) A-I      intronic
chr15:67405710(+) A-I      intronic
chr15:67455441(+) A-I      intronic
chr15:67366158(+) A-I      intronic
chr15:67368198(+) A-I      intronic
chr15:67455332(+) A-I      intronic
chr15:67368203(+) A-I      intronic
chr15:67363962(+) A-I      intronic
chr15:67415671(+) A-I      intronic
chr15:67415676(+) A-I      intronic
chr15:67405711(+) A-I      intronic
chr15:67405702(+) A-I      intronic
chr15:67368210(+) A-I      intronic
chr15:67416395(+) A-I      intronic
chr15:67416561(+) A-I      intronic
chr15:67415408(+) A-I      intronic
chr15:67415680(+) A-I      intronic
chr15:67368146(+) A-I      intronic
chr15:67410342(+) A-I      intronic
chr15:67416562(+) A-I      intronic
chr15:67456395(+) A-I      intronic
chr15:67362119(+) A-I      intronic
chr15:67478497(+) A-I      intronic
chr15:67368044(+) A-I      intronic
chr15:67452949(+) A-I      intronic
chr15:67363875(+) A-I      intronic
chr15:67483483(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SMAD3
chr15:67368146(+) A-G intron -    22484847
chr15:67415675(+) A-G intron -    22484847
chr15:67451478(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SMAD3
chr15:67356224-67356225(+) m6A 5'UTR       24981863
chr15:67356275-67356276(+) m6A 5'UTR       24981863
chr15:67358549-67358550(+) m1A CDS//intron       26863196//26863410
chr15:67358614-67358615(+) m6A CDS//intron       24284625//24981863//26404942
chr15:67390932-67390933(+) m6A 5'UTR//intron       24284625
chr15:67418223-67418224(+) m6A 5'UTR//intron       24981863
chr15:67457312-67457313(+) m6A 5'UTR//CDS//exon       24284625
chr15:67457419-67457420(+) m6A CDS//exon       24284625//24981863
chr15:67457677-67457678(+) m6A CDS//exon       24284625//24981863
chr15:67459093-67459094(+) m6A 5'UTR//intron       24284625//24981863
chr15:67459118-67459119(+) m6A 5'UTR//CDS//exon       24284625//24981863
chr15:67459154-67459155(+) m6A 5'UTR//CDS//exon       24284625//24981863//26404942
chr15:67459173-67459174(+) m6A CDS//exon       24284625//24981863//26404942
chr15:67462900-67462901(+) m6A CDS//exon       24284625//24981863//26404942
chr15:67462971-67462972(+) m6A exon//intron       24284625//24981863
chr15:67466703-67466704(+) m6A exon//intron       24284625
chr15:67466805-67466806(+) m6A exon//intron       24284625
chr15:67473784-67473785(+) Cm CDS//intron       -
chr15:67482753-67482754(+) m6A CDS//exon//intron       24284625//24209618//24981863
chr15:67482876-67482877(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22608085
chr15:67482943-67482944(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr15:67483023-67483024(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr15:67483035-67483036(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr15:67483056-67483057(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr15:67483073-67483074(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483144-67483145(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483180-67483181(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483229-67483230(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483246-67483247(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483310-67483311(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483358-67483359(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483405-67483406(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483430-67483431(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483480-67483481(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483512-67483513(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483525-67483526(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483562-67483563(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67483916-67483917(+) m6A 3'UTR//intron       24284625//24981863
chr15:67483927-67483928(+) m6A 3'UTR//intron       24284625//24981863
chr15:67484050-67484051(+) m6A 3'UTR//intron       26404942
chr15:67484252-67484253(+) m6A 3'UTR//intron       24209618//24981863//26404942
chr15:67484320-67484321(+) m6A 3'UTR//intron       24209618//24981863//26404942
chr15:67484329-67484330(+) m6A 3'UTR//intron       24981863//26404942
chr15:67484334-67484335(+) m6A 3'UTR//intron       24981863//26404942
chr15:67484616-67484617(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr15:67484642-67484643(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67484675-67484676(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67484712-67484713(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67484720-67484721(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67484730-67484731(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67484830-67484831(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//22575960//22608085
chr15:67484870-67484871(+) m6A 3'UTR//intron       24284625//24209618
chr15:67484878-67484879(+) m6A 3'UTR//intron       24284625//24209618
chr15:67485027-67485028(+) m6A 3'UTR//intron       24981863
chr15:67485134-67485135(+) m6A 3'UTR//intron       24981863//26404942
chr15:67485187-67485188(+) m6A 3'UTR//intron       24981863//26404942
chr15:67485202-67485203(+) m6A 3'UTR//intron       24981863//26404942
chr15:67485289-67485290(+) m6A 3'UTR//exon       26404942
chr15:67485323-67485324(+) m6A 3'UTR//exon       26404942
chr15:67485510-67485511(+) m6A 3'UTR//exon       26404942
chr15:67485525-67485526(+) m6A 3'UTR       26404942
chr15:67485548-67485549(+) m6A 3'UTR       26404942
chr15:67485684-67485685(+) m6A 3'UTR       24981863
chr15:67485711-67485712(+) m6A 3'UTR       24981863
chr15:67485871-67485872(+) m6A 3'UTR       24284625
chr15:67485909-67485910(+) m6A 3'UTR       24284625
chr15:67485924-67485925(+) m6A 3'UTR       24284625
chr15:67485951-67485952(+) m6A 3'UTR       24284625
chr15:67486071-67486072(+) m6A 3'UTR       26404942
chr15:67486164-67486165(+) m6A 3'UTR       26404942
chr15:67486385-67486386(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085
chr15:67486439-67486440(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085
chr15:67486513-67486514(+) m6A 3'UTR       24284625//24981863//26404942
chr15:67486518-67486519(+) m6A 3'UTR       24284625//24981863//26404942
chr15:67486677-67486678(+) m6A 3'UTR       24209618//24981863//26404942//22608085
chr15:67486744-67486745(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085
chr15:67486762-67486763(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085
chr15:67486784-67486785(+) m6A 3'UTR       24209618//24981863//26404942//22608085
chr15:67486799-67486800(+) m6A 3'UTR       24209618//24981863//26404942//22608085
chr15:67486908-67486909(+) m6A 3'UTR       24284625//24981863//26404942
chr15:67486917-67486918(+) m6A 3'UTR       24284625//24981863//26404942
chr15:67486972-67486973(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22608085
chr15:67487053-67487054(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr15:67487060-67487061(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr15:67487074-67487075(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr15:67487094-67487095(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67487142-67487143(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr15:67487253-67487254(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr15:67487285-67487286(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SMAD3
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug RP11-875O11.2
Tivozanib       9911830
Zibotentan       9910224
PI-103       9884685
Osi-930       9868037
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473
Panobinostat       6918837
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167
Axitinib       6450551
(2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)       57339144
l-685,458       5479543
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide       5113032
Tubastatin A       49850262
2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine       46224516
Ruxolitinib       25126798
Cabozantinib       25102847
Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314
Quizartinib       24889392
Ponatinib       24826799
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
Gsk-690693       16725726
Fedratinib       16722836
N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide       16095342
1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea       1401
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
Osi-027       135398516
Methotrexate       126941
Lestaurtinib       126565
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511
Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964
Linifanib       11485656
N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846
Afatinib       10184653
Selumetinib       10127622
N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147
Masitinib       10074640
Genentech Cpd 10       -
JW-7-24-1       -
KIN001-236       -
KIN001-244       -
KIN001-260       -
KIN001-270       -
NPK76-II-72-1       -
QL-XI-92       -
TL-1-85       -
TL-2-105       -
VNLG/124       -
XMD14-99       -

Interaction Network (The top 100 interactions):


Interactor1: RP11-875O11.2
Interactor2: SMAD3

Evidence Support:


Prediction-Evidence miRTarBase//miRWalk
Support Database ViRBase

References:


PMID 33475497 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Our data revealed that 709 miRNAs target these mRNAs, among which 145 functional MTIs were found and were subsequently selected as the most important interactions for further examination.

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