Basic Information:

  VIRBase ID:  

HHID00109257

  Virus:  

Severe acute respiratory syndrome-related coronavirus (SARS)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      FLJ42969:  NR_033962          SMAD2:  NM_001135937     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	FLJ42969	SMAD2
miRBase Accession/Entrez ID	441374	4087
Organism	Homo sapiens	Homo sapiens
Category	lncRNA	mRNA
Alias	-	hMAD-2//hSMAD2//JV18//JV18-1//MADH2//MADR2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt	PMID
LincSNP 3.0	FLJ42969	rs737707 chr8:101071224 A/G         19571809 rs12679969 chr8:101075321 G/T         20522523 rs4734021 chr8:101055932 G/T         20613766 rs6468755 chr8:101054030 A/C         21042317 rs4734020 chr8:101055599 C/G         23722424

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SMAD2	chr18:45411706(-) A-I      intronic chr18:45408847(-) A-I      intronic chr18:45408841(-) A-I      intronic chr18:45363668(-) A-I      3'UTR chr18:45411757(-) A-I      intronic chr18:45411752(-) A-I      intronic chr18:45451008(-) A-I      intronic chr18:45363704(-) A-I      3'UTR chr18:45450997(-) A-I      intronic chr18:45439387(-) A-I      intronic chr18:45437525(-) A-I      intronic chr18:45363690(-) A-I      3'UTR chr18:45363689(-) A-I      3'UTR chr18:45363677(-) A-I      3'UTR chr18:45379889(-) A-I      intronic chr18:45411740(-) A-I      intronic chr18:45408840(-) A-I      intronic chr18:45411734(-) A-I      intronic chr18:45411732(-) A-I      intronic chr18:45411717(-) A-I      intronic chr18:45411709(-) A-I      intronic chr18:45363671(-) A-I      3'UTR chr18:45451101(-) A-I      intronic chr18:45439480(-) A-I      intronic chr18:45439485(-) A-I      intronic chr18:45439486(-) A-I      intronic chr18:45439564(-) A-I      intronic chr18:45450390(-) A-I      intronic chr18:45450415(-) A-I      intronic chr18:45450450(-) A-I      intronic chr18:45450454(-) A-I      intronic chr18:45450456(-) A-I      intronic chr18:45450457(-) A-I      intronic chr18:45450519(-) A-I      intronic chr18:45386945(-) A-I      intronic chr18:45450495(-) A-I      intronic chr18:45387470(-) A-I      intronic chr18:45387553(-) A-I      intronic chr18:45387583(-) A-I      intronic chr18:45387605(-) A-I      intronic chr18:45387664(-) A-I      intronic chr18:45387691(-) A-I      intronic chr18:45399317(-) A-I      intronic chr18:45404949(-) A-I      intronic chr18:45404959(-) A-I      intronic chr18:45418735(-) A-I      intronic chr18:45386445(-) A-I      intronic chr18:45386450(-) A-I      intronic chr18:45408795(-) A-I      intronic chr18:45386382(-) A-I      intronic chr18:45386378(-) A-I      intronic chr18:45386315(-) A-I      intronic chr18:45408682(-) A-I      intronic chr18:45408763(-) A-I      intronic chr18:45408764(-) A-I      intronic chr18:45408819(-) A-I      intronic chr18:45411604(-) A-I      intronic chr18:45411639(-) A-I      intronic chr18:45411703(-) A-I      intronic chr18:45411771(-) A-I      intronic chr18:45412098(-) A-I      intronic chr18:45412128(-) A-I      intronic chr18:45412129(-) A-I      intronic chr18:45412135(-) A-I      intronic chr18:45386926(-) A-I      intronic chr18:45412141(-) A-I      intronic chr18:45412150(-) A-I      intronic chr18:45417593(-) A-I      intronic chr18:45386759(-) A-I      intronic chr18:45386867(-) A-I      intronic chr18:45386479(-) A-I      intronic chr18:45386496(-) A-I      intronic chr18:45386758(-) A-I      intronic chr18:45386384(-) A-I      intronic chr18:45451107(-) A-I      intronic chr18:45405342(-) A-I      intronic chr18:45450536(-) A-I      intronic chr18:45417594(-) A-I      intronic chr18:45439363(-) A-I      intronic chr18:45439428(-) A-I      intronic chr18:45450363(-) A-I      intronic chr18:45408463(-) A-I      intronic chr18:45417671(-) A-I      intronic chr18:45411733(-) A-I      intronic chr18:45411614(-) A-I      intronic chr18:45386940(-) A-I      intronic chr18:45411811(-) A-I      intronic chr18:45386873(-) A-I      intronic chr18:45412115(-) A-I      intronic chr18:45434140(-) A-I      intronic chr18:45450956(-) A-I      intronic chr18:45450971(-) A-I      intronic chr18:45386421(-) A-I      intronic chr18:45386735(-) A-I      intronic chr18:45386499(-) A-I      intronic chr18:45386431(-) A-I      intronic chr18:45386803(-) A-I      intronic chr18:45417431(-) A-I      intronic chr18:45411653(-) A-I      intronic chr18:45386913(-) A-I      intronic chr18:45450437(-) A-I      intronic chr18:45404918(-) A-I      intronic chr18:45450451(-) A-I      intronic chr18:45386491(-) A-I      intronic chr18:45404820(-) A-I      intronic chr18:45382090(-) A-I      intronic chr18:45451011(-) A-I      intronic chr18:45382004(-) A-I      intronic chr18:45418744(-) A-I      intronic chr18:45405391(-) A-I      intronic chr18:45386745(-) A-I      intronic chr18:45412271(-) A-I      intronic chr18:45450376(-) A-I      intronic chr18:45386438(-) A-I      intronic chr18:45450929(-) A-I      intronic chr18:45418770(-) A-I      intronic chr18:45386807(-) A-I      intronic chr18:45450890(-) A-I      intronic chr18:45418663(-) A-I      intronic chr18:45450905(-) A-I      intronic chr18:45417419(-) A-I      intronic chr18:45412184(-) A-I      intronic chr18:45418739(-) A-I      intronic chr18:45411776(-) A-I      intronic chr18:45450503(-) A-I      intronic chr18:45386905(-) A-I      intronic chr18:45386406(-) A-I      intronic chr18:45386927(-) A-I      intronic chr18:45418817(-) A-I      intronic chr18:45451060(-) A-I      intronic chr18:45408472(-) A-I      intronic chr18:45412270(-) A-I      intronic chr18:45386866(-) A-I      intronic chr18:45386862(-) A-I      intronic chr18:45450533(-) A-I      intronic chr18:45451000(-) A-I      intronic chr18:45417564(-) A-I      intronic chr18:45434151(-) A-I      intronic chr18:45408508(-) A-I      intronic chr18:45450375(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SMAD2	chr18:45386491(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SMAD2	chr18:45335476-45335477(-) m6A 3'UTR       - chr18:45335507-45335508(-) m6A 3'UTR       - chr18:45335581-45335582(-) m6A 3'UTR       - chr18:45335617-45335618(-) m6A 3'UTR       - chr18:45335626-45335627(-) m6A 3'UTR       - chr18:45335655-45335656(-) m6A 3'UTR       - chr18:45335703-45335704(-) m6A 3'UTR       - chr18:45367936-45367937(-) m6A 3'UTR       24981863//27773535 chr18:45367963-45367964(-) m6A 3'UTR       24981863//27773535//22608085 chr18:45368087-45368088(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr18:45368119-45368120(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr18:45368168-45368169(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr18:45368252-45368253(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr18:45368269-45368270(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr18:45368284-45368285(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr18:45379653-45379654(-) m6A intron       27773535//22608085 chr18:45379658-45379659(-) m6A intron       27773535//22608085 chr18:45379683-45379684(-) m6A intron       27773535//22608085 chr18:45394740-45394741(-) m6A CDS//exon       24284625 chr18:45394781-45394782(-) m6A CDS//exon       24284625 chr18:45395619-45395620(-) m6A CDS//exon       24284625 chr18:45396893-45396894(-) Tm CDS//exon//intron       - chr18:45396913-45396914(-) m6A CDS//exon//intron       27773535 chr18:45421644-45421645(-) m6A exon//intron       27773535 chr18:45422921-45422922(-) m6A CDS       25456834//24981863//27773535//27371828//22608085 chr18:45422964-45422965(-) m6A CDS       25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr18:45422976-45422977(-) m1A CDS       26863196 chr18:45423058-45423059(-) Tm CDS       - chr18:45423069-45423070(-) m1A CDS       26863196 chr18:45423085-45423086(-) m6A CDS       25456834//24981863//28052920//27773535//27371828//27773536//22575960 chr18:45423128-45423129(-) m6A 5'UTR       25456834//24981863//27773535//27371828//27773536//22575960 chr18:45446444-45446445(-) m6A 5'UTR//intron       27773535//22575960 chr18:45446460-45446461(-) m6A 5'UTR//intron       27773535//22575960 chr18:45456749-45456750(-) m6A 5'UTR//intron       24981863//27773536 chr18:45456773-45456774(-) m6A 5'UTR//intron       24981863//27371828//27773536 chr18:45456787-45456788(-) m6A 5'UTR//intron       24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FLJ42969	Exosome Blood     -
	SMAD2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: FLJ42969
Interactor2: SMAD2

Evidence Support:

Prediction-Evidence	miRTarBase//miRWalk
Support Database	ViRBase

References:

PMID	33475497	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Our data revealed that 709 miRNAs target these mRNAs, among which 145 functional MTIs were found and were subsequently selected as the most important interactions for further examination.