Detail Information

Basic Information:


  VIRBase ID:  

HHID00109249

  Virus:  

SARS-CoV-2 (Wuhan-1 EPI_ISL_402125)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-5197-3p:           TMEM167A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-5197-3p TMEM167A
miRBase
Accession/Entrez ID		 MIMAT0021131 153339
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - TMEM167

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-5197-3p
rs1347866830 chr5:143679936    G/C
rs1405555825 chr5:143679942    G/A
rs1411653302 chr5:143679932    C/A
rs892818585 chr5:143679941    C/T
rs77549240 chr5:143679930    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMEM167A
chr5:82370728(-) A-I      intronic
chr5:82370767(-) A-I      intronic
chr5:82357352(-) A-I      intronic
chr5:82357366(-) A-I      intronic
chr5:82368486(-) A-I      intronic
chr5:82371512(-) A-I      intronic
chr5:82368423(-) A-I      intronic
chr5:82368539(-) A-I      intronic
chr5:82370727(-) A-I      intronic
chr5:82371371(-) A-I      intronic
chr5:82371481(-) A-I      intronic
chr5:82371398(-) A-I      intronic
chr5:82371391(-) A-I      intronic
chr5:82357418(-) A-I      intronic
chr5:82370796(-) A-I      intronic
chr5:82368530(-) A-I      intronic
chr5:82357487(-) A-I      intronic
chr5:82357415(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMEM167A
chr5:82357418(-) A-G intron -    22484847
chr5:82370861(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM167A
chr5:82349080-82349081(-) m6A 3'UTR       24284625//25456834//22608085
chr5:82349209-82349210(-) m6A 3'UTR       22608085
chr5:82352749-82352750(-) m6A 3'UTR//exon       24981863//22608085
chr5:82352801-82352802(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085
chr5:82352850-82352851(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085
chr5:82352856-82352857(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085
chr5:82360830-82360831(-) m6A CDS//exon//intron       24284625
chr5:82360841-82360842(-) m6A CDS//exon//intron       24284625
chr5:82367200-82367201(-) m6A exon//intron       24284625//24981863
chr5:82373205-82373206(-) m6A 5'UTR//exon//intron       25456834//24981863
chr5:82373649-82373650(-) m6A exon       25456834
chr5:82373665-82373666(-) m6A exon       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-5197-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TMEM167A
Chromatin K562 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-5197-3p
Interactor2: TMEM167A

Evidence Support:


Prediction-Evidence miRTargetLink
Support Database ViRBase

References:


PMID 33467206 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Four genes were found to be regulated by both miR-5197-3p and miR-7-1-3p (NPM3, RAB10, HMGN2, TMEM167A), while CUL3 is regulated by both miR-5197-3p and miR-3529-5p; VGLL4 and WASL are dependent on both miR-3529-5p and miR-7-1-3p. The gene interaction networks with the three miRs are shown in Figure 4D.

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