Basic Information:

  VIRBase ID:  

HHID00109247

  Virus:  

SARS-CoV-2 (Wuhan-1 EPI_ISL_402125)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-5197-3p:  MIMAT0021131          NPM3:  NM_006993     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-5197-3p	NPM3
miRBase Accession/Entrez ID	MIMAT0021131	10360
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PORMIN//TMEM123

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-5197-3p	rs1347866830 chr5:143679936    G/C rs1405555825 chr5:143679942    G/A rs1411653302 chr5:143679932    C/A rs892818585 chr5:143679941    C/T rs77549240 chr5:143679930    G/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NPM3	chr10:103542295-103542296(-) m6A CDS//exon       27773535 chr10:103542381-103542382(-) m6A exon//intron       27773535 chr10:103543160-103543161(-) m1A 5'UTR       26863196//26863410

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-5197-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NPM3	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-5197-3p
Interactor2: NPM3

Evidence Support:

Prediction-Evidence	miRTargetLink
Support Database	ViRBase

References:

PMID	33467206	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Four genes were found to be regulated by both miR-5197-3p and miR-7-1-3p (NPM3, RAB10, HMGN2, TMEM167A), while CUL3 is regulated by both miR-5197-3p and miR-3529-5p; VGLL4 and WASL are dependent on both miR-3529-5p and miR-7-1-3p. The gene interaction networks with the three miRs are shown in Figure 4D.