Basic Information:

  VIRBase ID:  

HHID00109246

  Virus:  

SARS-CoV-2 (Wuhan-1 EPI_ISL_402125)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-5197-3p:  MIMAT0021131          CUL3:  NM_003590     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-5197-3p	CUL3
miRBase Accession/Entrez ID	MIMAT0021131	8452
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CUL-3//PHA2E

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-5197-3p	rs1347866830 chr5:143679936    G/C rs1405555825 chr5:143679942    G/A rs1411653302 chr5:143679932    C/A rs892818585 chr5:143679941    C/T rs77549240 chr5:143679930    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CUL3	chr2:225400254(-) A-I      Syn:Leu->Leu chr2:225446357(-) A-I      intronic chr2:225446387(-) A-I      intronic chr2:225446388(-) A-I      intronic chr2:225446389(-) A-I      intronic chr2:225446393(-) A-I      intronic chr2:225446395(-) A-I      intronic chr2:225446399(-) A-I      intronic chr2:225386369(-) A-I      intronic chr2:225386376(-) A-I      intronic chr2:225395867(-) A-I      intronic chr2:225395873(-) A-I      intronic chr2:225400081(-) A-I      intronic chr2:225400124(-) A-I      intronic chr2:225446396(-) A-I      intronic chr2:225386349(-) A-I      intronic chr2:225374127(-) A-I      intronic chr2:225386330(-) A-I      intronic chr2:225386335(-) A-I      intronic chr2:225386362(-) A-I      intronic chr2:225386336(-) A-I      intronic chr2:225412192(-) A-I      intronic chr2:225394176(-) A-I      intronic chr2:225394141(-) A-I      intronic chr2:225394130(-) A-I      intronic chr2:225432102(-) A-I      intronic chr2:225432113(-) A-I      intronic chr2:225432308(-) A-I      intronic chr2:225432309(-) A-I      intronic chr2:225432455(-) A-I      intronic chr2:225445239(-) A-I      intronic chr2:225445949(-) A-I      intronic chr2:225445974(-) A-I      intronic chr2:225446091(-) A-I      intronic chr2:225446288(-) A-I      intronic chr2:225446527(-) A-I      intronic chr2:225446050(-) A-I      intronic chr2:225447972(-) A-I      intronic chr2:225448042(-) A-I      intronic chr2:225373627(-) A-I      intronic chr2:225373603(-) A-I      intronic chr2:225373616(-) A-I      intronic chr2:225373672(-) A-I      intronic chr2:225380489(-) A-I      intronic chr2:225380505(-) A-I      intronic chr2:225380574(-) A-I      intronic chr2:225380583(-) A-I      intronic chr2:225380658(-) A-I      intronic chr2:225381528(-) A-I      intronic chr2:225381546(-) A-I      intronic chr2:225382224(-) A-I      intronic chr2:225382241(-) A-I      intronic chr2:225399692(-) A-I      intronic chr2:225400035(-) A-I      intronic chr2:225400082(-) A-I      intronic chr2:225400100(-) A-I      intronic chr2:225382242(-) A-I      intronic chr2:225382290(-) A-I      intronic chr2:225386220(-) A-I      intronic chr2:225396078(-) A-I      intronic chr2:225396042(-) A-I      intronic chr2:225396032(-) A-I      intronic chr2:225396000(-) A-I      intronic chr2:225395982(-) A-I      intronic chr2:225395972(-) A-I      intronic chr2:225395916(-) A-I      intronic chr2:225395877(-) A-I      intronic chr2:225399939(-) A-I      intronic chr2:225400159(-) A-I      intronic chr2:225404859(-) A-I      intronic chr2:225404918(-) A-I      intronic chr2:225404934(-) A-I      intronic chr2:225404938(-) A-I      intronic chr2:225432059(-) A-I      intronic chr2:225386250(-) A-I      intronic chr2:225386280(-) A-I      intronic chr2:225386315(-) A-I      intronic chr2:225386318(-) A-I      intronic chr2:225387355(-) A-I      intronic chr2:225387377(-) A-I      intronic chr2:225387519(-) A-I      intronic chr2:225394087(-) A-I      intronic chr2:225394090(-) A-I      intronic chr2:225394214(-) A-I      intronic chr2:225394121(-) A-I      intronic chr2:225395834(-) A-I      intronic chr2:225395407(-) A-I      intronic chr2:225395367(-) A-I      intronic chr2:225394766(-) A-I      intronic chr2:225394289(-) A-I      intronic chr2:225394264(-) A-I      intronic chr2:225394259(-) A-I      intronic chr2:225394238(-) A-I      intronic chr2:225381537(-) A-I      intronic chr2:225394237(-) A-I      intronic chr2:225394234(-) A-I      intronic chr2:225394227(-) A-I      intronic chr2:225394224(-) A-I      intronic chr2:225394222(-) A-I      intronic chr2:225394091(-) A-I      intronic chr2:225399596(-) A-I      intronic chr2:225380534(-) A-I      intronic chr2:225394832(-) A-I      intronic chr2:225394705(-) A-I      intronic chr2:225400028(-) A-I      intronic chr2:225447982(-) A-I      intronic chr2:225382380(-) A-I      intronic chr2:225395835(-) A-I      intronic chr2:225394310(-) A-I      intronic chr2:225445964(-) A-I      intronic chr2:225380547(-) A-I      intronic chr2:225432044(-) A-I      intronic chr2:225432120(-) A-I      intronic chr2:225386351(-) A-I      intronic chr2:225394869(-) A-I      intronic chr2:225373511(-) A-I      intronic chr2:225446846(-) A-I      intronic chr2:225400138(-) A-I      intronic chr2:225394153(-) A-I      intronic chr2:225394145(-) A-I      intronic chr2:225446360(-) A-I      intronic chr2:225381634(-) A-I      intronic chr2:225448026(-) A-I      intronic chr2:225381557(-) A-I      intronic chr2:225386230(-) A-I      intronic chr2:225380582(-) A-I      intronic chr2:225395902(-) A-I      intronic chr2:225381304(-) A-I      intronic chr2:225380558(-) A-I      intronic chr2:225380541(-) A-I      intronic chr2:225395932(-) A-I      intronic chr2:225446973(-) A-I      intronic chr2:225394844(-) A-I      intronic chr2:225396055(-) A-I      intronic chr2:225396009(-) A-I      intronic chr2:225377033(-) A-I      intronic chr2:225382218(-) A-I      intronic chr2:225399972(-) A-I      intronic chr2:225446061(-) A-I      intronic chr2:225446492(-) A-I      intronic chr2:225391251(-) A-I      intronic chr2:225395978(-) A-I      intronic chr2:225374152(-) A-I      intronic chr2:225395936(-) A-I      intronic chr2:225374116(-) A-I      intronic chr2:225387433(-) A-I      intronic chr2:225382357(-) A-I      intronic chr2:225386321(-) A-I      intronic chr2:225399996(-) A-I      intronic chr2:225374109(-) A-I      intronic chr2:225446390(-) A-I      intronic chr2:225445279(-) A-I      intronic chr2:225386219(-) A-I      intronic chr2:225374064(-) A-I      intronic chr2:225446819(-) A-I      intronic chr2:225380586(-) A-I      intronic chr2:225374090(-) A-I      intronic chr2:225395974(-) A-I      intronic chr2:225381198(-) A-I      intronic chr2:225395508(-) A-I      intronic chr2:225396100(-) A-I      intronic chr2:225382278(-) A-I      intronic chr2:225395944(-) A-I      intronic chr2:225446322(-) A-I      intronic chr2:225399915(-) A-I      intronic chr2:225396077(-) A-I      intronic chr2:225395542(-) A-I      intronic chr2:225386276(-) A-I      intronic chr2:225395975(-) A-I      intronic chr2:225381130(-) A-I      intronic chr2:225446358(-) A-I      intronic chr2:225394797(-) A-I      intronic chr2:225374111(-) A-I      intronic chr2:225380538(-) A-I      intronic chr2:225391203(-) A-I      intronic chr2:225395981(-) A-I      intronic chr2:225373521(-) A-I      intronic chr2:225395878(-) A-I      intronic chr2:225386273(-) A-I      intronic chr2:225446336(-) A-I      intronic chr2:225432115(-) A-I      intronic chr2:225387531(-) A-I      intronic chr2:225400151(-) A-I      intronic chr2:225382268(-) A-I      intronic chr2:225446069(-) A-I      intronic chr2:225445990(-) A-I      intronic chr2:225374107(-) A-I      intronic chr2:225446026(-) A-I      intronic chr2:225445235(-) A-I      intronic chr2:225373999(-) A-I      intronic chr2:225374110(-) A-I      intronic chr2:225373442(-) A-I      intronic chr2:225395941(-) A-I      intronic chr2:225446886(-) A-I      intronic chr2:225448039(-) A-I      intronic chr2:225395980(-) A-I      intronic chr2:225395999(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CUL3	chr2:225386285(-) A-I intron -    22327324 chr2:225395944(-) A-I intron -    22327324 chr2:225348125(-) A-I intron -    21960545 chr2:225348167(-) A-I intron -    21960545 chr2:225348229(-) A-I intron -    21960545 chr2:225356452(-) A-I intron -    21960545 chr2:225372788(-) A-I intron -    21960545 chr2:225374033(-) A-I intron -    21960545 chr2:225382380(-) A-I intron -    21960545 chr2:225386286(-) A-I intron -    21960545 chr2:225396100(-) A-I intron -    21960545 chr2:225396105(-) A-I intron -    21960545 chr2:225365436(-) T-C intron -    22484847 chr2:225373442(-) A-G intron -    22484847 chr2:225373567(-) A-G intron -    22484847 chr2:225373999(-) A-G intron -    22484847 chr2:225374107(-) A-G intron -    22484847 chr2:225374109(-) A-G intron -    22484847 chr2:225374111(-) A-G intron -    22484847 chr2:225374116(-) A-G intron -    22484847 chr2:225381198(-) A-G intron -    22484847 chr2:225381641(-) A-G intron -    22484847 chr2:225382145(-) A-G intron -    22484847 chr2:225382218(-) A-G intron -    22484847 chr2:225382308(-) A-G intron -    22484847 chr2:225382380(-) A-G intron -    22484847 chr2:225386166(-) C-A intron -    22484847 chr2:225386219(-) A-G intron -    22484847 chr2:225386230(-) A-G intron -    22484847 chr2:225386273(-) A-G intron -    22484847 chr2:225386276(-) A-G intron -    22484847 chr2:225386285(-) A-G intron -    22484847 chr2:225386308(-) G-A intron -    22484847 chr2:225386327(-) G-A intron -    22484847 chr2:225386351(-) A-G intron -    22484847 chr2:225387523(-) A-G intron -    22484847 chr2:225387531(-) A-G intron -    22484847 chr2:225391203(-) A-G intron -    22484847 chr2:225391251(-) A-G intron -    22484847 chr2:225391302(-) G-T intron -    22484847 chr2:225394145(-) A-G intron -    22484847 chr2:225394153(-) A-G intron -    22484847 chr2:225394294(-) A-G intron -    22484847 chr2:225394310(-) A-G intron -    22484847 chr2:225394797(-) A-G intron -    22484847 chr2:225394832(-) A-G intron -    22484847 chr2:225394844(-) A-G intron -    22484847 chr2:225394869(-) A-G intron -    22484847 chr2:225394942(-) A-G intron -    22484847 chr2:225395389(-) A-G intron -    22484847 chr2:225395467(-) A-G intron -    22484847 chr2:225395508(-) A-G intron -    22484847 chr2:225395512(-) A-G intron -    22484847 chr2:225395542(-) A-G intron -    22484847 chr2:225395902(-) A-G intron -    22484847 chr2:225395932(-) A-G intron -    22484847 chr2:225395936(-) A-G intron -    22484847 chr2:225395941(-) A-G intron -    22484847 chr2:225395944(-) A-G intron -    22484847 chr2:225395973(-) A-G intron -    22484847 chr2:225395974(-) A-G intron -    22484847 chr2:225395975(-) A-G intron -    22484847 chr2:225395978(-) A-G intron -    22484847 chr2:225395979(-) C-T intron -    22484847 chr2:225395980(-) A-G intron -    22484847 chr2:225395981(-) A-G intron -    22484847 chr2:225395998(-) A-G intron -    22484847 chr2:225396009(-) A-G intron -    22484847 chr2:225396028(-) A-G intron -    22484847 chr2:225396055(-) A-G intron -    22484847 chr2:225396077(-) A-G intron -    22484847 chr2:225396100(-) A-G intron -    22484847 chr2:225399510(-) A-G intron -    22484847 chr2:225399618(-) A-G intron -    22484847 chr2:225399972(-) A-G intron -    22484847 chr2:225400012(-) A-G intron -    22484847 chr2:225400019(-) A-G intron -    22484847 chr2:225400028(-) A-G intron -    22484847 chr2:225400083(-) A-G intron -    22484847 chr2:225400091(-) A-G intron -    22484847 chr2:225400151(-) A-G intron -    22484847 chr2:225404777(-) A-G intron -    22484847 chr2:225414043(-) A-T intron -    22484847 chr2:225432115(-) A-G intron -    22484847 chr2:225432449(-) A-G intron -    22484847 chr2:225445279(-) A-G intron -    22484847 chr2:225445357(-) A-G intron -    22484847 chr2:225445370(-) A-G intron -    22484847 chr2:225445870(-) A-G intron -    22484847 chr2:225445871(-) A-G intron -    22484847 chr2:225445922(-) T-C intron -    22484847 chr2:225445964(-) A-G intron -    22484847 chr2:225445990(-) A-G intron -    22484847 chr2:225446000(-) A-G intron -    22484847 chr2:225446026(-) A-G intron -    22484847 chr2:225446061(-) A-G intron -    22484847 chr2:225446069(-) A-G intron -    22484847 chr2:225446322(-) A-G intron -    22484847 chr2:225446336(-) A-G intron -    22484847 chr2:225446380(-) A-G intron -    22484847 chr2:225446390(-) A-G intron -    22484847 chr2:225446445(-) A-G intron -    22484847 chr2:225446862(-) T-A intron -    22484847 chr2:225446875(-) T-C intron -    22484847 chr2:225446973(-) A-G intron -    22484847 chr2:225448026(-) A-G intron -    22484847 chr2:225448039(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CUL3	chr2:225338686-225338687(-) m6A 3'UTR//exon       27773535 chr2:225338839-225338840(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr2:225338912-225338913(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr2:225338930-225338931(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr2:225338999-225339000(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr2:225339027-225339028(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr2:225342991-225342992(-) m6A 3'UTR//CDS//exon//intron       24981863//28052920//27773535//22608085 chr2:225343020-225343021(-) m6A CDS//exon//intron       24981863//28052920//27773535//22608085 chr2:225343051-225343052(-) m6A CDS//exon//intron       24981863//28052920//27773535 chr2:225343111-225343112(-) m6A exon//intron       24981863//27773535 chr2:225362550-225362551(-) m6A CDS//exon       27773535 chr2:225365102-225365103(-) m6A CDS//exon       27773535 chr2:225367724-225367725(-) m6A CDS//exon       27773535 chr2:225367759-225367760(-) m6A CDS//exon       27773535 chr2:225368387-225368388(-) m6A CDS//exon       27773535 chr2:225370748-225370749(-) Y CDS//exon       26075521 chr2:225370777-225370778(-) m6A CDS//exon       - chr2:225376110-225376111(-) Y CDS//exon       26075521 chr2:225376152-225376153(-) m6A CDS       24981863 chr2:225376179-225376180(-) m6A CDS//exon       24981863 chr2:225379331-225379332(-) m6A 3'UTR//CDS//exon       24981863 chr2:225379377-225379378(-) m6A 3'UTR//CDS//exon       24981863 chr2:225422535-225422536(-) m6A CDS//exon//intron       27773535 chr2:225422547-225422548(-) m6A CDS//exon//intron       27773535 chr2:225425196-225425197(-) m6A exon//intron       27773535 chr2:225425208-225425209(-) m6A exon//intron       27773535 chr2:225425229-225425230(-) m6A exon//intron       27773535 chr2:225425324-225425325(-) m6A exon//intron       27773535 chr2:225427463-225427464(-) m6A 5'UTR//intron       27773535 chr2:225434513-225434514(-) m6A 5'UTR//intron       24209618 chr2:225434520-225434521(-) m6A 5'UTR//intron       24209618 chr2:225449688-225449689(-) m6A CDS       24209618//27371828 chr2:225449977-225449978(-) m6A 5'UTR       24209618//24981863//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-5197-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CUL3	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-5197-3p
Interactor2: CUL3

Evidence Support:

Prediction-Evidence	miRTargetLink
Support Database	ViRBase

References:

PMID	33467206	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Four genes were found to be regulated by both miR-5197-3p and miR-7-1-3p (NPM3, RAB10, HMGN2, TMEM167A), while CUL3 is regulated by both miR-5197-3p and miR-3529-5p; VGLL4 and WASL are dependent on both miR-3529-5p and miR-7-1-3p. The gene interaction networks with the three miRs are shown in Figure 4D.