Basic Information:

  VIRBase ID:  

HHID00109245

  Virus:  

SARS-CoV-2 (Wuhan-1 EPI_ISL_402125)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-5197-3p:  MIMAT0021131          HMGN2:  NM_005517     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-5197-3p	HMGN2
miRBase Accession/Entrez ID	MIMAT0021131	3151
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HMG17

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-5197-3p	rs1347866830 chr5:143679936    G/C rs1405555825 chr5:143679942    G/A rs1411653302 chr5:143679932    C/A rs892818585 chr5:143679941    C/T rs77549240 chr5:143679930    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HMGN2	chr1:26802464(+) T-A intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HMGN2	chr1:26798973-26798974(+) m6A exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr1:26798982-26798983(+) m6A exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr1:26799009-26799010(+) m1A 5'UTR//exon       26863196//26863410 chr1:26799031-26799032(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960 chr1:26799931-26799932(+) m6A exon//intron       24209618//24981863//22575960 chr1:26800053-26800054(+) m6A exon//intron       24209618//24981863//27773535//22575960 chr1:26800071-26800072(+) m6A exon//intron       24209618//24981863//27773535//22575960 chr1:26800139-26800140(+) m6A exon//intron       24209618//24981863//27773535//22575960 chr1:26800262-26800263(+) m6A exon//intron       24209618//24981863//27773535//22575960 chr1:26800270-26800271(+) m6A exon//intron       24209618//24981863//27773535//22575960 chr1:26800280-26800281(+) m6A exon//intron       24209618//24981863//27773535//22575960 chr1:26800345-26800346(+) m6A exon//intron       27773535 chr1:26800459-26800460(+) m6A exon//intron       - chr1:26800479-26800480(+) m6A exon//intron       24981863 chr1:26800577-26800578(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr1:26801149-26801150(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr1:26801549-26801550(+) m6A exon//intron       24981863 chr1:26801777-26801778(+) m6A 3'UTR//exon       24981863 chr1:26802014-26802015(+) m6A 3'UTR//exon       24981863 chr1:26802035-26802036(+) m6A 3'UTR//exon       24981863 chr1:26802047-26802048(+) m6A 3'UTR//exon       24981863 chr1:26802091-26802092(+) m6A 3'UTR//exon       24981863 chr1:26802228-26802229(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-5197-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	HMGN2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-5197-3p
Interactor2: HMGN2

Evidence Support:

Prediction-Evidence	miRTargetLink
Support Database	ViRBase

References:

PMID	33467206	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Four genes were found to be regulated by both miR-5197-3p and miR-7-1-3p (NPM3, RAB10, HMGN2, TMEM167A), while CUL3 is regulated by both miR-5197-3p and miR-3529-5p; VGLL4 and WASL are dependent on both miR-3529-5p and miR-7-1-3p. The gene interaction networks with the three miRs are shown in Figure 4D.