Basic Information:

  VIRBase ID:  

HHID00109241

  Virus:  

SARS-CoV-2 (Wuhan-1 EPI_ISL_402125)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-7-1-3p:  MIMAT0004553          TMEM167A:  NM_174909     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-7-1-3p	TMEM167A
miRBase Accession/Entrez ID	MIMAT0004553	153339
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TMEM167

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-7-1-3p	rs1419148287 chr9:83969783    T/C rs1463372700 chr9:83969781    T/G rs767086173 chr9:83969775    G/A rs772876693 chr9:83969780    CTG/C rs775309693 chr9:83969778    G/C rs1411851112 chr9:83969779    ACTGTGATTTGTTGT/A rs760333621 chr9:83969787    T/C rs767563035 chr9:83969791    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM167A	chr5:82370728(-) A-I      intronic chr5:82370767(-) A-I      intronic chr5:82357352(-) A-I      intronic chr5:82357366(-) A-I      intronic chr5:82368486(-) A-I      intronic chr5:82371512(-) A-I      intronic chr5:82368423(-) A-I      intronic chr5:82368539(-) A-I      intronic chr5:82370727(-) A-I      intronic chr5:82371371(-) A-I      intronic chr5:82371481(-) A-I      intronic chr5:82371398(-) A-I      intronic chr5:82371391(-) A-I      intronic chr5:82357418(-) A-I      intronic chr5:82370796(-) A-I      intronic chr5:82368530(-) A-I      intronic chr5:82357487(-) A-I      intronic chr5:82357415(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM167A	chr5:82357418(-) A-G intron -    22484847 chr5:82370861(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM167A	chr5:82349080-82349081(-) m6A 3'UTR       24284625//25456834//22608085 chr5:82349209-82349210(-) m6A 3'UTR       22608085 chr5:82352749-82352750(-) m6A 3'UTR//exon       24981863//22608085 chr5:82352801-82352802(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085 chr5:82352850-82352851(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085 chr5:82352856-82352857(-) m6A 3'UTR//exon       24284625//24981863//22575960//22608085 chr5:82360830-82360831(-) m6A CDS//exon//intron       24284625 chr5:82360841-82360842(-) m6A CDS//exon//intron       24284625 chr5:82367200-82367201(-) m6A exon//intron       24284625//24981863 chr5:82373205-82373206(-) m6A 5'UTR//exon//intron       25456834//24981863 chr5:82373649-82373650(-) m6A exon       25456834 chr5:82373665-82373666(-) m6A exon       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-7-1-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	TMEM167A	Chromatin K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-7-1-3p
Interactor2: TMEM167A

Evidence Support:

Prediction-Evidence	miRTargetLink
Support Database	ViRBase

References:

PMID	33467206	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Four genes were found to be regulated by both miR-5197-3p and miR-7-1-3p (NPM3, RAB10, HMGN2, TMEM167A), while CUL3 is regulated by both miR-5197-3p and miR-3529-5p; VGLL4 and WASL are dependent on both miR-3529-5p and miR-7-1-3p. The gene interaction networks with the three miRs are shown in Figure 4D.