Basic Information:

  VIRBase ID:  

HHID00109232

  Virus:  

SARS-CoV-2 (NCCP43326)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-588:  MIMAT0003255          ACE2:  NM_021804     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-588	ACE2
miRBase Accession/Entrez ID	MIMAT0003255	59272
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACEH

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-588	rs1221870465 chr6:126484654    A/G rs1305299278 chr6:126484655    A/G rs1439105717 chr6:126484666    C/A rs761187038 chr6:126484656    TG/T rs765028368 chr6:126484663    G/T rs903390621 chr6:126484659    G/A rs1041858987 chr6:126484651    C/T rs1444441984 chr6:126484649    G/T rs761948782 chr6:126484653    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACE2	chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535 chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535 chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535 chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535 chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535 chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535 chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535 chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-588	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ACE2	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-588	Doxorubicin 31703 Drug interaction    RC00006055 Verapamil 2520 Drug interaction    RC00006054

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-588	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-588
Interactor2: ACE2

Evidence Support:

Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	33199671	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Among the predicted miRNAs, seven candidates were selected; hsa-miR-221-3p and hsa-miR-95-5p targeting ADAM17; hsa-miR-588, hsa-miR-587, and hsa-miR-582-5p targeting ACE2; and hsa-miR-140-3p and hsa-miR-1255b targeting TMPRSS2.