Basic Information:

  VIRBase ID:  

HHID00109084

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548o-5p:  MIMAT0022738          GULP1:  NR_164745     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548o-5p	GULP1
miRBase Accession/Entrez ID	MIMAT0022738	51454
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CED-6//CED6//GULP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548o-5p	rs748987263 chr20:38516580    C/A rs748987263 chr20:38516580    C/T rs750604040 chr20:38516581    G/A rs1186654040 chr20:38516574    T/G rs1299647098 chr20:38516572    A/T rs1379757384 chr20:38516576    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GULP1	chr2:189368211(+) A-I      intronic chr2:189368257(+) A-I      intronic chr2:189395373(+) A-I      intronic chr2:189398093(+) A-I      intronic chr2:189395418(+) A-I      intronic chr2:189398091(+) A-I      intronic chr2:189398085(+) A-I      intronic chr2:189398084(+) A-I      intronic chr2:189398069(+) A-I      intronic chr2:189398044(+) A-I      intronic chr2:189395427(+) A-I      intronic chr2:189398197(+) A-I      intronic chr2:189400316(+) A-I      intronic chr2:189421932(+) A-I      intronic chr2:189425059(+) A-I      intronic chr2:189368031(+) A-I      intronic chr2:189281337(+) A-I      intronic chr2:189219035(+) A-I      intronic chr2:189233902(+) A-I      intronic chr2:189165842(+) A-I      intronic chr2:189165773(+) A-I      intronic chr2:189180466(+) A-I      intronic chr2:189368204(+) A-I      intronic chr2:189278865(+) A-I      intronic chr2:189294177(+) A-I      intronic chr2:189294159(+) A-I      intronic chr2:189278850(+) A-I      intronic chr2:189283281(+) A-I      intronic chr2:189283275(+) A-I      intronic chr2:189278841(+) A-I      intronic chr2:189331220(+) A-I      ncRNA chr2:189247355(+) A-I      intronic chr2:189282635(+) A-I      intronic chr2:189247354(+) A-I      intronic chr2:189283104(+) A-I      intronic chr2:189294051(+) A-I      intronic chr2:189294106(+) A-I      intronic chr2:189173931(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GULP1	chr2:189156502-189156503(+) m6A 5'UTR//exon       25456834//24981863//22575960 chr2:189156535-189156536(+) m6A 5'UTR//exon       25456834//24981863//22575960 chr2:189156721-189156722(+) m6A 5'UTR//exon       25456834//24981863 chr2:189156768-189156769(+) m6A 5'UTR//exon       25456834//24981863 chr2:189156836-189156837(+) m6A 5'UTR//exon       25456834 chr2:189387505-189387506(+) m6A CDS//exon//intron       24981863 chr2:189387518-189387519(+) m6A CDS//exon//intron       24981863 chr2:189387547-189387548(+) m6A CDS//exon//intron       24981863 chr2:189434049-189434050(+) m6A CDS//exon       24981863 chr2:189434057-189434058(+) m6A CDS//exon       24981863 chr2:189434761-189434762(+) m6A CDS//exon       24981863 chr2:189434769-189434770(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548o-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	GULP1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548o-5p
Interactor2: GULP1

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.