Detail Information

Basic Information:


  VIRBase ID:  

HHID00108620

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548h-5p:           DENND1B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-548h-5p DENND1B
miRBase
Accession/Entrez ID		 MIMAT0005928 163486
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C1ORF18//C1orf218//FAM31B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-548h-5p
rs1423828980 chr14:64095086    C/T
rs144194694 chr14:64095094    G/A
rs377270470 chr14:64095095    C/A
rs377270470 chr14:64095095    C/T
rs573600271 chr14:64095093    C/T
rs1000965353 chr16:11306498    A/G
rs1307745356 chr16:11306500    C/T
rs1353674605 chr16:11306491    G/A
rs1353674605 chr16:11306491    G/T
rs149601213 chr16:11306499    C/T
rs563549339 chr16:11306501    G/A
rs956694910 chr16:11306502    C/T
rs988390663 chr16:11306503    G/A
rs1247348117 chr17:13543606    C/T
rs1307196788 chr17:13543599    CAA/C
rs1341303954 chr17:13543598    A/AAAGTAATAG
rs1348342088 chr17:13543609    G/A
rs9913045 chr17:13543607    G/A
rs1285835311 chr8:27048929    A/G
rs1295636494 chr8:27048928    CA/C
rs1306358433 chr8:27048936    G/A
rs1352583339 chr8:27048937    C/T
rs1354349512 chr8:27048928    C/T
rs1391960313 chr8:27048933    A/C
rs561726723 chr8:27048935    C/T
rs748156409 chr8:27048926    G/A
rs748156409 chr8:27048926    G/T
rs1042357839 chr6:131792184    G/A
rs1225605725 chr6:131792194    T/C
rs1257986495 chr6:131792187    G/A
rs1345907099 chr6:131792186    G/T
rs1466227719 chr6:131792183    C/A
rs1466227719 chr6:131792183    C/T
rs906403807 chr6:131792185    C/A
rs1384709035 chr6:131792178    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DENND1B
chr1:197496684(-) A-I      intronic
chr1:197496685(-) A-I      intronic
chr1:197728211(-) A-I      intronic
chr1:197496658(-) A-I      intronic
chr1:197623664(-) A-I      intronic
chr1:197496676(-) A-I      intronic
chr1:197547460(-) A-I      intronic
chr1:197616876(-) A-I      intronic
chr1:197547535(-) A-I      intronic
chr1:197547530(-) A-I      intronic
chr1:197620990(-) A-I      intronic
chr1:197672329(-) A-I      intronic
chr1:197741837(-) A-I      intronic
chr1:197547569(-) A-I      intronic
chr1:197741945(-) A-I      intronic
chr1:197672282(-) A-I      intronic
chr1:197672255(-) A-I      intronic
chr1:197636802(-) A-I      intronic
chr1:197673384(-) A-I      intronic
chr1:197547591(-) A-I      intronic
chr1:197683244(-) A-I      intronic
chr1:197620910(-) A-I      intronic
chr1:197672312(-) A-I      intronic
chr1:197636801(-) A-I      intronic
chr1:197617030(-) A-I      intronic
chr1:197620924(-) A-I      intronic
chr1:197720777(-) A-I      intronic
chr1:197673182(-) A-I      intronic
chr1:197620914(-) A-I      intronic
chr1:197620988(-) A-I      intronic
chr1:197720801(-) A-I      intronic
chr1:197620934(-) A-I      intronic
chr1:197728162(-) A-I      intronic
chr1:197616896(-) A-I      intronic
chr1:197728189(-) A-I      intronic
chr1:197728192(-) A-I      intronic
chr1:197672354(-) A-I      intronic
chr1:197729537(-) A-I      intronic
chr1:197728232(-) A-I      intronic
chr1:197728167(-) A-I      intronic
chr1:197728239(-) A-I      intronic
chr1:197736156(-) A-I      intronic
chr1:197620950(-) A-I      intronic
chr1:197728245(-) A-I      intronic
chr1:197728751(-) A-I      intronic
chr1:197736166(-) A-I      intronic
chr1:197616956(-) A-I      intronic
chr1:197621057(-) A-I      intronic
chr1:197729643(-) A-I      intronic
chr1:197512253(-) A-I      intronic
chr1:197723676(-) A-I      intronic
chr1:197636031(-) A-I      intronic
chr1:197617038(-) A-I      intronic
chr1:197625928(-) A-I      intronic
chr1:197636632(-) A-I      intronic
chr1:197512176(-) A-I      intronic
chr1:197604588(-) A-I      intronic
chr1:197548093(-) A-I      intronic
chr1:197636730(-) A-I      intronic
chr1:197617041(-) A-I      intronic
chr1:197514366(-) A-I      intronic
chr1:197732286(-) A-I      intronic
chr1:197514365(-) A-I      intronic
chr1:197636724(-) A-I      intronic
chr1:197636022(-) A-I      intronic
chr1:197617025(-) A-I      intronic
chr1:197689508(-) A-I      intronic
chr1:197636652(-) A-I      intronic
chr1:197636116(-) A-I      intronic
chr1:197514372(-) A-I      intronic
chr1:197604604(-) A-I      intronic
chr1:197616946(-) A-I      intronic
chr1:197623628(-) A-I      intronic
chr1:197617043(-) A-I      intronic
chr1:197690405(-) A-I      intronic
chr1:197621058(-) A-I      intronic
chr1:197636177(-) A-I      intronic
chr1:197636733(-) A-I      intronic
chr1:197608291(-) A-I      intronic
chr1:197729649(-) A-I      intronic
chr1:197512205(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DENND1B
chr1:197616946(-) A-G intron -    22484847
chr1:197636031(-) A-G intron -    22484847
chr1:197732286(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DENND1B
chr1:197473920-197473921(-) m6A 3'UTR       27773535
chr1:197474021-197474022(-) m6A 3'UTR       27773535
chr1:197478783-197478784(-) m6A 3'UTR       27773535
chr1:197479530-197479531(-) m6A 3'UTR       24981863//27773535//22608085
chr1:197479563-197479564(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:197479594-197479595(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr1:197479599-197479600(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:197479611-197479612(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:197479617-197479618(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:197479626-197479627(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:197479685-197479686(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:197479702-197479703(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:197479801-197479802(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:197479816-197479817(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:197479831-197479832(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:197479868-197479869(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr1:197479917-197479918(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828//22575960//22608085
chr1:197479994-197479995(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr1:197480863-197480864(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr1:197480975-197480976(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr1:197480997-197480998(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr1:197481009-197481010(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr1:197509118-197509119(-) m6A 3'UTR//CDS       27773535
chr1:197509179-197509180(-) m6A 3'UTR//CDS       24981863//27773535
chr1:197510094-197510095(-) m6A 3'UTR//CDS       24981863//27773535
chr1:197510100-197510101(-) m6A 3'UTR//CDS       24981863//27773535
chr1:197510121-197510122(-) m6A 3'UTR//CDS       24981863//27773535
chr1:197704520-197704521(-) m6A exon//intron       22608085
chr1:197704579-197704580(-) m6A exon//intron       27773535//27371828//22608085
chr1:197704620-197704621(-) m6A exon//intron       22608085
chr1:197704633-197704634(-) m6A exon//intron       22608085
chr1:197704639-197704640(-) m6A exon//intron       22608085
chr1:197704681-197704682(-) m6A exon//intron       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-548h-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
DENND1B
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-548h-5p
Interactor2: DENND1B

Evidence Support:


Prediction-Evidence miRDB
Support Database ViRBase

References:


PMID 33201341 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.

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