Basic Information:

  VIRBase ID:  

HHID00108617

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548h-5p:  MIMAT0005928          ARL6IP6:  NM_152522     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548h-5p	ARL6IP6
miRBase Accession/Entrez ID	MIMAT0005928	151188
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AIP-6//AIP6//PFAAP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548h-5p	rs1423828980 chr14:64095086    C/T rs144194694 chr14:64095094    G/A rs377270470 chr14:64095095    C/A rs377270470 chr14:64095095    C/T rs573600271 chr14:64095093    C/T rs1000965353 chr16:11306498    A/G rs1307745356 chr16:11306500    C/T rs1353674605 chr16:11306491    G/A rs1353674605 chr16:11306491    G/T rs149601213 chr16:11306499    C/T rs563549339 chr16:11306501    G/A rs956694910 chr16:11306502    C/T rs988390663 chr16:11306503    G/A rs1247348117 chr17:13543606    C/T rs1307196788 chr17:13543599    CAA/C rs1341303954 chr17:13543598    A/AAAGTAATAG rs1348342088 chr17:13543609    G/A rs9913045 chr17:13543607    G/A rs1285835311 chr8:27048929    A/G rs1295636494 chr8:27048928    CA/C rs1306358433 chr8:27048936    G/A rs1352583339 chr8:27048937    C/T rs1354349512 chr8:27048928    C/T rs1391960313 chr8:27048933    A/C rs561726723 chr8:27048935    C/T rs748156409 chr8:27048926    G/A rs748156409 chr8:27048926    G/T rs1042357839 chr6:131792184    G/A rs1225605725 chr6:131792194    T/C rs1257986495 chr6:131792187    G/A rs1345907099 chr6:131792186    G/T rs1466227719 chr6:131792183    C/A rs1466227719 chr6:131792183    C/T rs906403807 chr6:131792185    C/A rs1384709035 chr6:131792178    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARL6IP6	chr2:153604268(+) A-I      intronic chr2:153614730(+) A-I      intronic chr2:153614686(+) A-I      intronic chr2:153614692(+) A-I      intronic chr2:153614693(+) A-I      intronic chr2:153614731(+) A-I      intronic chr2:153614742(+) A-I      intronic chr2:153614691(+) A-I      intronic chr2:153614713(+) A-I      intronic chr2:153604347(+) A-I      intronic chr2:153604353(+) A-I      intronic chr2:153606802(+) A-I      intronic chr2:153606947(+) A-I      intronic chr2:153609567(+) A-I      intronic chr2:153606773(+) A-I      intronic chr2:153596716(+) A-I      intronic chr2:153604194(+) A-I      intronic chr2:153596710(+) A-I      intronic chr2:153596691(+) A-I      intronic chr2:153606875(+) A-I      intronic chr2:153591025(+) A-I      intronic chr2:153602593(+) A-I      intronic chr2:153604190(+) A-I      intronic chr2:153606817(+) A-I      intronic chr2:153606787(+) A-I      intronic chr2:153609570(+) A-I      intronic chr2:153604223(+) A-I      intronic chr2:153606886(+) A-I      intronic chr2:153606721(+) A-I      intronic chr2:153604151(+) A-I      intronic chr2:153606962(+) A-I      intronic chr2:153591055(+) A-I      intronic chr2:153596803(+) A-I      intronic chr2:153604495(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARL6IP6	chr2:153591025(+) A-G intron -    22484847 chr2:153602593(+) A-G intron -    22484847 chr2:153604151(+) A-G intron -    22484847 chr2:153604189(+) A-G intron -    22484847 chr2:153604190(+) A-G intron -    22484847 chr2:153604223(+) A-G intron -    22484847 chr2:153606721(+) A-G intron -    22484847 chr2:153606817(+) A-G intron -    22484847 chr2:153606823(+) A-G intron -    22484847 chr2:153606940(+) A-G intron -    22484847 chr2:153609663(+) T-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARL6IP6	chr2:153574411-153574412(+) m6A exon       25456834 chr2:153574580-153574581(+) m6A 5'UTR//intron       27773535 chr2:153574617-153574618(+) m6A 5'UTR//intron       27773535 chr2:153574658-153574659(+) m6A 5'UTR//intron       27773535 chr2:153574690-153574691(+) m1A 5'UTR//intron       26863196//26863410 chr2:153574700-153574701(+) m6A 5'UTR//intron       24981863//27773535 chr2:153574748-153574749(+) m6A 5'UTR//intron       27773536 chr2:153616263-153616264(+) m6A 3'UTR//CDS//exon       24284625 chr2:153616272-153616273(+) m6A 3'UTR//CDS//exon       24284625 chr2:153616354-153616355(+) m6A 3'UTR//exon       24284625//24981863 chr2:153616383-153616384(+) m6A 3'UTR//exon       24284625//24981863 chr2:153616439-153616440(+) m6A 3'UTR//exon       24284625//24981863 chr2:153616447-153616448(+) m6A 3'UTR//exon       24284625//24981863 chr2:153616503-153616504(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548h-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	ARL6IP6	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548h-5p
Interactor2: ARL6IP6

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.