Basic Information:

  VIRBase ID:  

HHID00108442

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548j-5p:  MIMAT0005875          CAPN2:  NM_001748     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548j-5p	CAPN2
miRBase Accession/Entrez ID	MIMAT0005875	824
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CANP2//CANPL2//CANPml//mCANP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548j-5p	rs1210209539 chr22:26555275    C/T rs545900525 chr22:26555280    G/C rs565141718 chr22:26555283    C/A rs565141718 chr22:26555283    C/G rs565141718 chr22:26555283    C/T rs751780445 chr22:26555284    G/A rs753744163 chr22:26555282    C/A rs757533254 chr22:26555285    C/A rs367750295 chr22:26555290    A/G rs976434292 chr22:26555292    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CAPN2	chr1:223950652(+) A-I      intronic chr1:223960904(+) A-I      intronic chr1:223950664(+) A-I      intronic chr1:223933217(+) A-I      intronic chr1:223950637(+) A-I      intronic chr1:223950626(+) A-I      intronic chr1:223910761(+) A-I      intronic chr1:223910901(+) A-I      intronic chr1:223956865(+) A-I      intronic chr1:223956962(+) A-I      intronic chr1:223954452(+) A-I      intronic chr1:223910922(+) A-I      intronic chr1:223957006(+) A-I      intronic chr1:223957032(+) A-I      intronic chr1:223957097(+) A-I      intronic chr1:223950628(+) A-I      intronic chr1:223923754(+) A-I      intronic chr1:223907162(+) A-I      intronic chr1:223907147(+) A-I      intronic chr1:223923582(+) A-I      intronic chr1:223954555(+) A-I      intronic chr1:223910844(+) A-I      intronic chr1:223910810(+) A-I      intronic chr1:223907094(+) A-I      intronic chr1:223910213(+) A-I      intronic chr1:223923682(+) A-I      intronic chr1:223922958(+) A-I      intronic chr1:223907062(+) A-I      intronic chr1:223910139(+) A-I      intronic chr1:223923691(+) A-I      intronic chr1:223924473(+) A-I      intronic chr1:223933258(+) A-I      intronic chr1:223929963(+) A-I      intronic chr1:223910936(+) A-I      intronic chr1:223907120(+) A-I      intronic chr1:223910841(+) A-I      intronic chr1:223923551(+) A-I      intronic chr1:223954541(+) A-I      intronic chr1:223957003(+) A-I      intronic chr1:223910885(+) A-I      intronic chr1:223930485(+) A-I      intronic chr1:223912416(+) A-I      intronic chr1:223907121(+) A-I      intronic chr1:223907126(+) A-I      intronic chr1:223954542(+) A-I      intronic chr1:223912446(+) A-I      intronic chr1:223952250(+) A-I      intronic chr1:223923559(+) A-I      intronic chr1:223923065(+) A-I      intronic chr1:223923070(+) A-I      intronic chr1:223922980(+) A-I      intronic chr1:223923110(+) A-I      intronic chr1:223923119(+) A-I      intronic chr1:223923059(+) A-I      intronic chr1:223923562(+) A-I      intronic chr1:223912554(+) A-I      intronic chr1:223923077(+) A-I      intronic chr1:223923561(+) A-I      intronic chr1:223956949(+) A-I      intronic chr1:223954409(+) A-I      intronic chr1:223923044(+) A-I      intronic chr1:223923029(+) A-I      intronic chr1:223950799(+) A-I      intronic chr1:223961439(+) A-I      intronic chr1:223957168(+) A-I      intronic chr1:223908097(+) A-I      intronic chr1:223961103(+) A-I      intronic chr1:223954404(+) A-I      intronic chr1:223910013(+) A-I      intronic chr1:223923621(+) A-I      intronic chr1:223926141(+) A-I      intronic chr1:223929786(+) A-I      intronic chr1:223910931(+) A-I      intronic chr1:223908130(+) A-I      intronic chr1:223897313(+) A-I      intronic chr1:223956952(+) A-I      intronic chr1:223956956(+) A-I      intronic chr1:223954403(+) A-I      intronic chr1:223933218(+) A-I      intronic chr1:223951567(+) A-I      intronic chr1:223910190(+) A-I      intronic chr1:223912683(+) A-I      intronic chr1:223910064(+) A-I      intronic chr1:223912490(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CAPN2	chr1:223922980(+) A-I intron -    22028664 chr1:223923059(+) A-I intron -    22028664 chr1:223923065(+) A-I intron -    22028664 chr1:223923070(+) A-I intron -    22028664 chr1:223923077(+) A-I intron -    22028664 chr1:223923110(+) A-I intron -    22028664 chr1:223923119(+) A-I intron -    22028664 chr1:223923123(+) A-I intron -    22028664 chr1:223954404(+) A-I intron -    21960545 chr1:223910761(+) A-I intron -    21960545 chr1:223930413(+) A-I intron -    21960545 chr1:223962879(+) G-A intron -    21725310 chr1:223908097(+) A-G intron -    22484847 chr1:223908130(+) A-G intron -    22484847 chr1:223912554(+) A-G intron -    22484847 chr1:223923559(+) A-G intron -    22484847 chr1:223923561(+) A-G intron -    22484847 chr1:223923562(+) A-G intron -    22484847 chr1:223923621(+) A-G intron -    22484847 chr1:223954403(+) A-G intron -    22484847 chr1:223954404(+) A-G intron -    22484847 chr1:223956956(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CAPN2	chr1:223889300-223889301(+) m6A 5'UTR       24981863 chr1:223889339-223889340(+) m6A 5'UTR       24981863 chr1:223889387-223889388(+) m6A 5'UTR       24981863 chr1:223900334-223900335(+) m6A 5'UTR//intron       24284625//24981863//22575960 chr1:223900373-223900374(+) m6A CDS//intron       24284625//26404942//22575960 chr1:223900433-223900434(+) m6A CDS//intron       24284625//26404942//22575960 chr1:223900484-223900485(+) m6A CDS//intron       24284625//22575960 chr1:223900549-223900550(+) m6A CDS//intron       24284625//22575960 chr1:223905512-223905513(+) m6A CDS       24284625//22575960 chr1:223931876-223931877(+) m6A CDS       26404942//22575960 chr1:223931894-223931895(+) m6A CDS       26404942//22575960 chr1:223934754-223934755(+) m6A CDS       26404942 chr1:223936756-223936757(+) m6A CDS//exon       26404942//22575960 chr1:223937129-223937130(+) m6A exon//intron       22575960 chr1:223938617-223938618(+) m6A CDS       24981863//22575960 chr1:223938657-223938658(+) m6A CDS       24981863//26404942//22575960 chr1:223939712-223939713(+) m6A CDS       24981863//26404942//22575960 chr1:223939721-223939722(+) m6A CDS//exon       24981863//26404942//22575960 chr1:223940559-223940560(+) m6A CDS//exon       24981863//26404942//22575960 chr1:223940593-223940594(+) m6A CDS//exon       24981863//26404942//22575960 chr1:223940613-223940614(+) m6A CDS//exon       24284625//24981863//26404942//22575960 chr1:223940649-223940650(+) m6A CDS//exon       24284625//24981863//26404942//22575960 chr1:223943196-223943197(+) m6A CDS//exon       24284625//25456834//24981863//26404942//22575960 chr1:223943319-223943320(+) m6A CDS//exon       24284625//25456834//24981863//26404942//22575960 chr1:223945138-223945139(+) m6A exon//intron       24284625 chr1:223945366-223945367(+) m6A exon//intron       25456834//24981863 chr1:223945412-223945413(+) m6A exon//intron       25456834//24981863 chr1:223945433-223945434(+) m6A exon//intron       25456834//24981863 chr1:223945442-223945443(+) m6A exon//intron       25456834//24981863 chr1:223945455-223945456(+) m6A exon//intron       25456834//24981863 chr1:223945477-223945478(+) m6A exon//intron       25456834//24981863 chr1:223945483-223945484(+) m6A exon//intron       25456834//24981863 chr1:223945511-223945512(+) m6A exon//intron       25456834//24981863 chr1:223946983-223946984(+) m6A CDS//exon       26404942 chr1:223947005-223947006(+) m6A CDS//exon       26404942 chr1:223947041-223947042(+) m6A CDS//exon       26404942 chr1:223947123-223947124(+) m6A CDS//exon       22575960 chr1:223949928-223949929(+) m6A CDS//exon       - chr1:223951881-223951882(+) m6A CDS//exon       22575960 chr1:223954103-223954104(+) m6A CDS//exon       22575960 chr1:223957909-223957910(+) m6A exon//intron       24284625//24981863 chr1:223957915-223957916(+) m6A exon//intron       24284625//24981863 chr1:223957921-223957922(+) m6A exon//intron       24284625//24981863 chr1:223957964-223957965(+) m6A exon//intron       24981863 chr1:223957976-223957977(+) m6A exon//intron       24981863 chr1:223958012-223958013(+) m6A exon//intron       24981863 chr1:223958199-223958200(+) Gm CDS//exon       - chr1:223958872-223958873(+) m6A exon//intron       - chr1:223960896-223960897(+) m6A exon//intron       24284625 chr1:223962582-223962583(+) m6A 3'UTR//exon       24284625//24981863//26404942//22608085 chr1:223962610-223962611(+) m6A 3'UTR//exon       24284625//24981863//26404942//22608085 chr1:223962644-223962645(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr1:223962661-223962662(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr1:223962918-223962919(+) m6A 3'UTR//exon       26404942 chr1:223962939-223962940(+) m6A 3'UTR//exon       26404942 chr1:223963008-223963009(+) m6A 3'UTR//exon       26404942 chr1:223963050-223963051(+) m6A 3'UTR//exon       26404942 chr1:223963106-223963107(+) m6A 3'UTR//exon       26404942 chr1:223963130-223963131(+) m6A 3'UTR//exon       26404942 chr1:223963137-223963138(+) m6A 3'UTR//exon       26404942 chr1:223963233-223963234(+) m6A 3'UTR//exon       24284625//26404942//27773535 chr1:223963263-223963264(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr1:223963277-223963278(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr1:223963297-223963298(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr1:223963314-223963315(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr1:223963341-223963342(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr1:223963350-223963351(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr1:223963390-223963391(+) m6A 3'UTR//exon       24981863//27773535 chr1:223963418-223963419(+) m6A 3'UTR//exon       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548j-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CAPN2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548j-5p
Interactor2: CAPN2

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.