Basic Information:

  VIRBase ID:  

HHID00108418

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548d-5p:  MIMAT0004812          PRRC1:  NM_130809     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548d-5p	PRRC1
miRBase Accession/Entrez ID	MIMAT0004812	133619
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548d-5p	rs1240978917 chr8:123348085    G/A rs1370161434 chr8:123348096    C/A rs1423052174 chr8:123348086    G/A rs1039169216 chr17:67471540    G/A rs1039169216 chr17:67471540    G/T rs543252291 chr17:67471553    A/G rs1196924094 chr8:123348101    A/G rs756308753 chr8:123348103    T/C rs768094101 chr17:67471554    T/G rs899430888 chr17:67471556    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRRC1	chr5:126864087(+) A-I      intronic chr5:126863413(+) A-I      intronic chr5:126863260(+) A-I      intronic chr5:126863305(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRRC1	chr5:126853346-126853347(+) m6A 5'UTR//exon       24284625//24981863 chr5:126859195-126859196(+) m6A CDS//exon       24284625//24209618//24981863 chr5:126859210-126859211(+) m6A CDS//exon       24284625//24209618//24981863 chr5:126859371-126859372(+) m6A exon//intron       24284625 chr5:126859787-126859788(+) m6A exon//intron       24284625//24209618//24981863 chr5:126860471-126860472(+) m6A CDS       24981863 chr5:126862365-126862366(+) m6A CDS       26404942 chr5:126862371-126862372(+) m6A CDS       26404942 chr5:126862408-126862409(+) m6A CDS       26404942 chr5:126862418-126862419(+) Y CDS       26075521 chr5:126869429-126869430(+) m6A CDS       24981863 chr5:126883653-126883654(+) m6A CDS//intron       24284625 chr5:126887420-126887421(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:126887497-126887498(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887580-126887581(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887599-126887600(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887614-126887615(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887627-126887628(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887633-126887634(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887777-126887778(+) m6A 3'UTR//exon//intron       26404942 chr5:126887787-126887788(+) m6A 3'UTR//exon//intron       26404942 chr5:126890573-126890574(+) m6A 3'UTR       27773535 chr5:126890578-126890579(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548d-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	PRRC1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-548d-5p	Atorvastatin 60823 Drug interaction    RC00007234 D-Glucose 5793 Drug interaction    RC00007233 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007232

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-548d-5p	Etoposide 36462       23028896

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548d-5p
Interactor2: PRRC1

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.