Basic Information:

  VIRBase ID:  

HHID00108324

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548c-5p:  MIMAT0004806          STXBP5:  NM_001127715     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548c-5p	STXBP5
miRBase Accession/Entrez ID	MIMAT0004806	134957
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LGL3//LLGL3//Nbla04300

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548c-5p	rs1188707087 chr12:64622544    C/A rs1188707087 chr12:64622544    C/T rs1371697031 chr12:64622552    G/A rs1391518567 chr12:64622541    T/C rs750959106 chr12:64622554    C/T rs1202383522 chr12:64622535    A/G rs374151873 chr12:64622540    A/G rs540698062 chr12:64622545    G/A rs764336601 chr12:64622536    A/C

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	STXBP5	chr6: 147710839

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STXBP5	chr6:147694413(+) A-I      intronic chr6:147642630(+) A-I      intronic chr6:147568227(+) A-I      intronic chr6:147568232(+) A-I      intronic chr6:147568861(+) A-I      intronic chr6:147663643(+) A-I      intronic chr6:147642638(+) A-I      intronic chr6:147532377(+) A-I      intronic chr6:147536629(+) A-I      intronic chr6:147536646(+) A-I      intronic chr6:147537363(+) A-I      intronic chr6:147537370(+) A-I      intronic chr6:147654384(+) A-I      intronic chr6:147537376(+) A-I      intronic chr6:147537408(+) A-I      intronic chr6:147654517(+) A-I      intronic chr6:147654394(+) A-I      intronic chr6:147537434(+) A-I      intronic chr6:147537449(+) A-I      intronic chr6:147569282(+) A-I      intronic chr6:147693754(+) A-I      intronic chr6:147694342(+) A-I      intronic chr6:147537372(+) A-I      intronic chr6:147576865(+) A-I      intronic chr6:147642644(+) A-I      intronic chr6:147539720(+) A-I      intronic chr6:147642643(+) A-I      intronic chr6:147569161(+) A-I      intronic chr6:147569160(+) A-I      intronic chr6:147534443(+) A-I      intronic chr6:147532822(+) A-I      intronic chr6:147532792(+) A-I      intronic chr6:147694355(+) A-I      intronic chr6:147694422(+) A-I      intronic chr6:147532852(+) A-I      intronic chr6:147547308(+) A-I      intronic chr6:147694433(+) A-I      intronic chr6:147596713(+) A-I      intronic chr6:147694421(+) A-I      intronic chr6:147674149(+) A-I      intronic chr6:147642673(+) A-I      intronic chr6:147694349(+) A-I      intronic chr6:147532809(+) A-I      intronic chr6:147545509(+) A-I      intronic chr6:147642659(+) A-I      intronic chr6:147532835(+) A-I      intronic chr6:147693635(+) A-I      intronic chr6:147648695(+) A-I      intronic chr6:147532973(+) A-I      intronic chr6:147532960(+) A-I      intronic chr6:147547388(+) A-I      intronic chr6:147532849(+) A-I      intronic chr6:147694251(+) A-I      intronic chr6:147644632(+) A-I      intronic chr6:147694518(+) A-I      intronic chr6:147532758(+) A-I      intronic chr6:147694293(+) A-I      intronic chr6:147644645(+) A-I      intronic chr6:147547309(+) A-I      intronic chr6:147532961(+) A-I      intronic chr6:147645611(+) A-I      intronic chr6:147694416(+) A-I      intronic chr6:147642635(+) A-I      intronic chr6:147579609(+) A-I      intronic chr6:147694348(+) A-I      intronic chr6:147694359(+) A-I      intronic chr6:147532325(+) A-I      intronic chr6:147648735(+) A-I      intronic chr6:147532906(+) A-I      intronic chr6:147532848(+) A-I      intronic chr6:147532826(+) A-I      intronic chr6:147648814(+) A-I      intronic chr6:147694447(+) A-I      intronic chr6:147641031(+) A-I      intronic chr6:147547345(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STXBP5	chr6:147546347(+) A-I intron -    15342557 chr6:147547185(+) A-I intron -    15342557 chr6:147547250(+) A-I intron -    15342557 chr6:147547308(+) A-I intron -    15342557 chr6:147547309(+) A-I intron -    15342557 chr6:147547318(+) A-I intron -    15342557 chr6:147547345(+) A-I intron -    15342557 chr6:147547388(+) A-I intron -    15342557 chr6:147570855(+) T-G intron -    22484847 chr6:147532325(+) A-G intron -    22484847 chr6:147532758(+) A-G intron -    22484847 chr6:147532826(+) A-G intron -    22484847 chr6:147532835(+) A-G intron -    22484847 chr6:147532960(+) A-G intron -    22484847 chr6:147532961(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STXBP5	chr6:147525620-147525621(+) m6A 5'UTR       24284625 chr6:147525665-147525666(+) m6A 5'UTR       24284625 chr6:147525762-147525763(+) m6A CDS       24284625 chr6:147684659-147684660(+) m6A CDS       24981863//22608085 chr6:147684719-147684720(+) m6A CDS       24981863//22608085 chr6:147684748-147684749(+) m6A CDS       24981863//22608085 chr6:147684822-147684823(+) m6A CDS       24981863 chr6:147706126-147706127(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:147706152-147706153(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:147706173-147706174(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:147706186-147706187(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:147706213-147706214(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr6:147706331-147706332(+) m6A 3'UTR       24209618//24981863//22608085 chr6:147706343-147706344(+) m6A 3'UTR       24209618//24981863//22608085 chr6:147706356-147706357(+) m6A 3'UTR       24209618//24981863//22608085 chr6:147706408-147706409(+) m6A 3'UTR       24981863//22608085 chr6:147706435-147706436(+) m6A 3'UTR       24981863//22608085 chr6:147706471-147706472(+) m6A 3'UTR       24981863//22608085 chr6:147706525-147706526(+) m6A 3'UTR       24981863//22608085 chr6:147706559-147706560(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548c-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Urine     -
	STXBP5	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-548c-5p	Emodin 3220 Drug interaction    RC00007211 Sorafenib 216239 Drug interaction    RC00007212

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-548c-5p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548c-5p
Interactor2: STXBP5

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.