Basic Information:

  VIRBase ID:  

HHID00108317

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548c-5p:  MIMAT0004806          PREX2:  NM_024870     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548c-5p	PREX2
miRBase Accession/Entrez ID	MIMAT0004806	80243
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DEP.2//DEPDC2//P-REX2//PPP1R129

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548c-5p	rs1188707087 chr12:64622544    C/A rs1188707087 chr12:64622544    C/T rs1371697031 chr12:64622552    G/A rs1391518567 chr12:64622541    T/C rs750959106 chr12:64622554    C/T rs1202383522 chr12:64622535    A/G rs374151873 chr12:64622540    A/G rs540698062 chr12:64622545    G/A rs764336601 chr12:64622536    A/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PREX2	chr8:69129103(+) A-I      intronic chr8:69129129(+) A-I      intronic chr8:68899211(+) A-I      intronic chr8:69005141(+) A-I      intronic chr8:69068489(+) A-I      intronic chr8:68899231(+) A-I      intronic chr8:69005136(+) A-I      intronic chr8:69005124(+) A-I      intronic chr8:68990660(+) A-I      intronic chr8:68990658(+) A-I      intronic chr8:68899257(+) A-I      intronic chr8:69127979(+) A-I      intronic chr8:69005098(+) A-I      intronic chr8:69128959(+) A-I      intronic chr8:69068536(+) A-I      intronic chr8:69068514(+) A-I      intronic chr8:69068509(+) A-I      intronic chr8:69064409(+) A-I      intronic chr8:69030403(+) A-I      intronic chr8:68919864(+) A-I      intronic chr8:68894571(+) A-I      intronic chr8:68894577(+) A-I      intronic chr8:69030413(+) A-I      intronic chr8:69068483(+) A-I      intronic chr8:69129118(+) A-I      intronic chr8:69030433(+) A-I      intronic chr8:69078974(+) A-I      intronic chr8:69068365(+) A-I      intronic chr8:69063470(+) A-I      intronic chr8:68991322(+) A-I      intronic chr8:69030412(+) A-I      intronic chr8:68910820(+) A-I      intronic chr8:69068339(+) A-I      intronic chr8:69140810(+) A-I      intronic chr8:69064476(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PREX2	chr8:69030403(+) A-I intron -    15545495 chr8:69030412(+) A-I intron -    15545495 chr8:69030413(+) A-I intron -    15545495 chr8:69030433(+) A-I intron -    15545495

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PREX2	chr8:69143755-69143756(+) m6A 3'UTR       24981863 chr8:69143816-69143817(+) m6A 3'UTR       24981863 chr8:69143833-69143834(+) m6A 3'UTR       24981863 chr8:69143893-69143894(+) m6A 3'UTR       24981863 chr8:69143996-69143997(+) m6A 3'UTR       - chr8:69144046-69144047(+) m6A 3'UTR       - chr8:69144087-69144088(+) m6A 3'UTR       22608085 chr8:69144096-69144097(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548c-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Urine     -
	PREX2	Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-548c-5p	Emodin 3220 Drug interaction    RC00007211 Sorafenib 216239 Drug interaction    RC00007212

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-548c-5p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548c-5p
Interactor2: PREX2

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.