Basic Information:

  VIRBase ID:  

HHID00108313

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548c-5p:  MIMAT0004806          TMEM135:  NM_022918     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548c-5p	TMEM135
miRBase Accession/Entrez ID	MIMAT0004806	65084
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PMP52

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548c-5p	rs1188707087 chr12:64622544    C/A rs1188707087 chr12:64622544    C/T rs1371697031 chr12:64622552    G/A rs1391518567 chr12:64622541    T/C rs750959106 chr12:64622554    C/T rs1202383522 chr12:64622535    A/G rs374151873 chr12:64622540    A/G rs540698062 chr12:64622545    G/A rs764336601 chr12:64622536    A/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM135	chr11:86908219(+) A-I      intronic chr11:86908209(+) A-I      intronic chr11:86908211(+) A-I      intronic chr11:86811848(+) A-I      intronic chr11:86795419(+) A-I      intronic chr11:87012400(+) A-I      intronic chr11:87012396(+) A-I      intronic chr11:86754182(+) A-I      intronic chr11:86808168(+) A-I      intronic chr11:86906499(+) A-I      intronic chr11:86858831(+) A-I      intronic chr11:87012390(+) A-I      intronic chr11:87012408(+) A-I      intronic chr11:87012457(+) A-I      intronic chr11:86913147(+) A-I      intronic chr11:86913113(+) A-I      intronic chr11:86913148(+) A-I      intronic chr11:86908204(+) A-I      intronic chr11:86908208(+) A-I      intronic chr11:86908202(+) A-I      intronic chr11:86908197(+) A-I      intronic chr11:86908168(+) A-I      intronic chr11:86908218(+) A-I      intronic chr11:86754171(+) A-I      intronic chr11:86754143(+) A-I      intronic chr11:86904041(+) A-I      intronic chr11:87012493(+) A-I      intronic chr11:86754618(+) A-I      intronic chr11:86904014(+) A-I      intronic chr11:86903955(+) A-I      intronic chr11:86800422(+) A-I      intronic chr11:86904046(+) A-I      intronic chr11:86894819(+) A-I      intronic chr11:86903261(+) A-I      intronic chr11:86988703(+) A-I      intronic chr11:86904042(+) A-I      intronic chr11:86903242(+) A-I      intronic chr11:87012435(+) A-I      intronic chr11:86800418(+) A-I      intronic chr11:86800550(+) A-I      intronic chr11:86800417(+) A-I      intronic chr11:87012422(+) A-I      intronic chr11:86894948(+) A-I      intronic chr11:86800394(+) A-I      intronic chr11:86781665(+) A-I      intronic chr11:86780248(+) A-I      intronic chr11:86780240(+) A-I      intronic chr11:87012421(+) A-I      intronic chr11:86903110(+) A-I      intronic chr11:86903103(+) A-I      intronic chr11:87012375(+) A-I      intronic chr11:86770487(+) A-I      intronic chr11:86765408(+) A-I      intronic chr11:87012365(+) A-I      intronic chr11:86933771(+) A-I      intronic chr11:86902449(+) A-I      intronic chr11:87010010(+) A-I      intronic chr11:86900256(+) A-I      intronic chr11:87010009(+) A-I      intronic chr11:87000592(+) A-I      intronic chr11:86756176(+) A-I      intronic chr11:86756175(+) A-I      intronic chr11:86756140(+) A-I      intronic chr11:86894385(+) A-I      intronic chr11:86754720(+) A-I      intronic chr11:86998644(+) A-I      intronic chr11:86754713(+) A-I      intronic chr11:86998639(+) A-I      intronic chr11:86998616(+) A-I      intronic chr11:86998466(+) A-I      intronic chr11:86894382(+) A-I      intronic chr11:86754706(+) A-I      intronic chr11:86993407(+) A-I      intronic chr11:86894368(+) A-I      intronic chr11:86754668(+) A-I      intronic chr11:86754650(+) A-I      intronic chr11:86754638(+) A-I      intronic chr11:86894350(+) A-I      intronic chr11:86754609(+) A-I      intronic chr11:86993406(+) A-I      intronic chr11:86754607(+) A-I      intronic chr11:86993363(+) A-I      intronic chr11:86754518(+) A-I      intronic chr11:86894284(+) A-I      intronic chr11:86754257(+) A-I      intronic chr11:86754098(+) A-I      intronic chr11:86988705(+) A-I      intronic chr11:86985761(+) A-I      intronic chr11:86985748(+) A-I      intronic chr11:86869581(+) A-I      intronic chr11:86963722(+) A-I      intronic chr11:86963719(+) A-I      intronic chr11:86944174(+) A-I      intronic chr11:86858939(+) A-I      intronic chr11:86944096(+) A-I      intronic chr11:86944095(+) A-I      intronic chr11:86944022(+) A-I      intronic chr11:86934675(+) A-I      intronic chr11:86902448(+) A-I      intronic chr11:86934643(+) A-I      intronic chr11:86934346(+) A-I      intronic chr11:86934271(+) A-I      intronic chr11:86913996(+) A-I      intronic chr11:86902304(+) A-I      intronic chr11:86900861(+) A-I      intronic chr11:86913995(+) A-I      intronic chr11:86913984(+) A-I      intronic chr11:86858886(+) A-I      intronic chr11:86913981(+) A-I      intronic chr11:86913954(+) A-I      intronic chr11:86900699(+) A-I      intronic chr11:86858863(+) A-I      intronic chr11:86913330(+) A-I      intronic chr11:86800411(+) A-I      intronic chr11:86913251(+) A-I      intronic chr11:86913193(+) A-I      intronic chr11:86812851(+) A-I      intronic chr11:86913154(+) A-I      intronic chr11:86910716(+) A-I      intronic chr11:86783503(+) A-I      intronic chr11:86906714(+) A-I      intronic chr11:86900689(+) A-I      intronic chr11:86906712(+) A-I      intronic chr11:86812770(+) A-I      intronic chr11:86906636(+) A-I      intronic chr11:86906538(+) A-I      intronic chr11:86987850(+) A-I      intronic chr11:86904089(+) A-I      intronic chr11:86904077(+) A-I      intronic chr11:86988690(+) A-I      intronic chr11:86861051(+) A-I      intronic chr11:86754710(+) A-I      intronic chr11:86899475(+) A-I      intronic chr11:86900328(+) A-I      intronic chr11:86811743(+) A-I      intronic chr11:86783622(+) A-I      intronic chr11:86913480(+) A-I      intronic chr11:86900303(+) A-I      intronic chr11:86903883(+) A-I      intronic chr11:86780234(+) A-I      intronic chr11:86811742(+) A-I      intronic chr11:86894953(+) A-I      intronic chr11:86993371(+) A-I      intronic chr11:86903971(+) A-I      intronic chr11:87009708(+) A-I      intronic chr11:86804866(+) A-I      intronic chr11:86863755(+) A-I      intronic chr11:86894827(+) A-I      intronic chr11:86795479(+) A-I      intronic chr11:86804864(+) A-I      intronic chr11:86985824(+) A-I      intronic chr11:86858307(+) A-I      intronic chr11:86804826(+) A-I      intronic chr11:87012437(+) A-I      intronic chr11:86993472(+) A-I      intronic chr11:86796749(+) A-I      intronic chr11:86900697(+) A-I      intronic chr11:87016538(+) A-I      intronic chr11:86985725(+) A-I      intronic chr11:86830538(+) A-I      intronic chr11:87030150(+) A-I      intronic chr11:86934667(+) A-I      intronic chr11:86812929(+) A-I      intronic chr11:86903947(+) A-I      intronic chr11:86900874(+) A-I      intronic chr11:86812895(+) A-I      intronic chr11:86754590(+) A-I      intronic chr11:86800308(+) A-I      intronic chr11:86894961(+) A-I      intronic chr11:86903944(+) A-I      intronic chr11:86900838(+) A-I      intronic chr11:86770903(+) A-I      intronic chr11:86804384(+) A-I      intronic chr11:86904114(+) A-I      intronic chr11:86754644(+) A-I      intronic chr11:86998572(+) A-I      intronic chr11:86985801(+) A-I      intronic chr11:86913897(+) A-I      intronic chr11:86913468(+) A-I      intronic chr11:86800482(+) A-I      intronic chr11:86994255(+) A-I      intronic chr11:86913137(+) A-I      intronic chr11:86830598(+) A-I      intronic chr11:87009771(+) A-I      intronic chr11:87009614(+) A-I      intronic chr11:87009581(+) A-I      intronic chr11:87000640(+) A-I      intronic chr11:87009880(+) A-I      intronic chr11:87012530(+) A-I      intronic chr11:86982775(+) A-I      intronic chr11:86872010(+) A-I      intronic chr11:86894797(+) A-I      intronic chr11:86902557(+) A-I      intronic chr11:87000760(+) A-I      intronic chr11:87002714(+) A-I      intronic chr11:86903910(+) A-I      intronic chr11:87012563(+) A-I      intronic chr11:86913172(+) A-I      intronic chr11:87000781(+) A-I      intronic chr11:86791911(+) A-I      intronic chr11:86944017(+) A-I      intronic chr11:86800303(+) A-I      intronic chr11:86783615(+) A-I      intronic chr11:87000772(+) A-I      intronic chr11:86900706(+) A-I      intronic chr11:86858980(+) A-I      intronic chr11:86858244(+) A-I      intronic chr11:86804367(+) A-I      intronic chr11:87000759(+) A-I      intronic chr11:86925769(+) A-I      intronic chr11:87009598(+) A-I      intronic chr11:87000732(+) A-I      intronic chr11:86757409(+) A-I      intronic chr11:86982844(+) A-I      intronic chr11:86902490(+) A-I      intronic chr11:87009562(+) A-I      intronic chr11:86903104(+) A-I      intronic chr11:86913342(+) A-I      intronic chr11:86830658(+) A-I      intronic chr11:86994256(+) A-I      intronic chr11:86812904(+) A-I      intronic chr11:86805637(+) A-I      intronic chr11:86913112(+) A-I      intronic chr11:86913124(+) A-I      intronic chr11:86795559(+) A-I      intronic chr11:86983603(+) A-I      intronic chr11:86943017(+) A-I      intronic chr11:87012399(+) A-I      intronic chr11:86929842(+) A-I      intronic chr11:87000638(+) A-I      intronic chr11:87009682(+) A-I      intronic chr11:87012425(+) A-I      intronic chr11:87012517(+) A-I      intronic chr11:86900751(+) A-I      intronic chr11:86844769(+) A-I      intronic chr11:87009627(+) A-I      intronic chr11:86933083(+) A-I      intronic chr11:86783199(+) A-I      intronic chr11:86903916(+) A-I      intronic chr11:87012531(+) A-I      intronic chr11:86982747(+) A-I      intronic chr11:86993582(+) A-I      intronic chr11:86900780(+) A-I      intronic chr11:86988838(+) A-I      intronic chr11:86913168(+) A-I      intronic chr11:86934847(+) A-I      intronic chr11:86900480(+) A-I      intronic chr11:86754180(+) A-I      intronic chr11:86754580(+) A-I      intronic chr11:86934336(+) A-I      intronic chr11:86999952(+) A-I      intronic chr11:86913268(+) A-I      intronic chr11:87009709(+) A-I      intronic chr11:86771062(+) A-I      intronic chr11:86863742(+) A-I      intronic chr11:86982790(+) A-I      intronic chr11:86783478(+) A-I      intronic chr11:86812868(+) A-I      intronic chr11:87012502(+) A-I      intronic chr11:86904036(+) A-I      intronic chr11:86944143(+) A-I      intronic chr11:86831287(+) A-I      intronic chr11:86796748(+) A-I      intronic chr11:87035543(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM135	chr11:87012517(+) A-I intron -    22327324 chr11:86806896(+) T-C intron -    22484847 chr11:86806921(+) G-A intron -    22484847 chr11:86806925(+) G-A intron -    22484847 chr11:86822702(+) A-G intron -    22484847 chr11:86900838(+) A-G intron -    22484847 chr11:87012517(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM135	chr11:86748932-86748933(+) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548c-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Urine     -
	TMEM135	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-548c-5p	Emodin 3220 Drug interaction    RC00007211 Sorafenib 216239 Drug interaction    RC00007212

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-548c-5p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548c-5p
Interactor2: TMEM135

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.