Detail Information

Basic Information:


  VIRBase ID:  

HHID00108280

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548c-5p:           SCML2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-548c-5p SCML2
miRBase
Accession/Entrez ID		 MIMAT0004806 10389
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-548c-5p
rs1188707087 chr12:64622544    C/A
rs1188707087 chr12:64622544    C/T
rs1371697031 chr12:64622552    G/A
rs1391518567 chr12:64622541    T/C
rs750959106 chr12:64622554    C/T
rs1202383522 chr12:64622535    A/G
rs374151873 chr12:64622540    A/G
rs540698062 chr12:64622545    G/A
rs764336601 chr12:64622536    A/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SCML2
chrX:18318332(-) A-I      intronic
chrX:18337534(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SCML2
chrX:18265909-18265910(-) m6A CDS       24981863
chrX:18265951-18265952(-) m6A CDS       24981863
chrX:18352185-18352186(-) m6A CDS       24981863
chrX:18352211-18352212(-) m6A 5'UTR       24981863
chrX:18372717-18372718(-) m6A 5'UTR       24981863
chrX:18372745-18372746(-) m6A 5'UTR       24981863
chrX:18372795-18372796(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-548c-5p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Urine     -
SCML2
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-548c-5p
Emodin 3220 Drug interaction    RC00007211
Sorafenib 216239 Drug interaction    RC00007212
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-548c-5p
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-548c-5p
Interactor2: SCML2

Evidence Support:


Prediction-Evidence miRDB
Support Database ViRBase

References:


PMID 33201341 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.

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