Basic Information:

  VIRBase ID:  

HHID00108246

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548c-5p:  MIMAT0004806          ACAT2:  NM_001303253     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548c-5p	ACAT2
miRBase Accession/Entrez ID	MIMAT0004806	39
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548c-5p	rs1188707087 chr12:64622544    C/A rs1188707087 chr12:64622544    C/T rs1371697031 chr12:64622552    G/A rs1391518567 chr12:64622541    T/C rs750959106 chr12:64622554    C/T rs1202383522 chr12:64622535    A/G rs374151873 chr12:64622540    A/G rs540698062 chr12:64622545    G/A rs764336601 chr12:64622536    A/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ACAT2	chr6:160193126(+) A-I      intronic chr6:160193096(+) A-I      intronic chr6:160193107(+) A-I      intronic chr6:160192825(+) A-I      intronic chr6:160193091(+) A-I      intronic chr6:160192781(+) A-I      intronic chr6:160192292(+) A-I      intronic chr6:160186664(+) A-I      intronic chr6:160184789(+) A-I      intronic chr6:160194106(+) A-I      intronic chr6:160193692(+) A-I      intronic chr6:160195736(+) A-I      intronic chr6:160195734(+) A-I      intronic chr6:160195505(+) A-I      intronic chr6:160194083(+) A-I      intronic chr6:160192829(+) A-I      intronic chr6:160181817(+) A-I      5'UTR chr6:160191976(+) A-I      intronic chr6:160191941(+) A-I      intronic chr6:160192047(+) A-I      intronic chr6:160191982(+) A-I      intronic chr6:160193249(+) A-I      intronic chr6:160195646(+) A-I      intronic chr6:160194120(+) A-I      intronic chr6:160194148(+) A-I      intronic chr6:160185078(+) A-I      intronic chr6:160195682(+) A-I      intronic chr6:160192813(+) A-I      intronic chr6:160184399(+) A-I      intronic chr6:160195565(+) A-I      intronic chr6:160193183(+) A-I      intronic chr6:160193123(+) A-I      intronic chr6:160195501(+) A-I      intronic chr6:160192291(+) A-I      intronic chr6:160194014(+) A-I      intronic chr6:160192848(+) A-I      intronic chr6:160192830(+) A-I      intronic chr6:160195589(+) A-I      intronic chr6:160192085(+) A-I      intronic chr6:160195693(+) A-I      intronic chr6:160185545(+) A-I      intronic chr6:160184465(+) A-I      intronic chr6:160191986(+) A-I      intronic chr6:160193136(+) A-I      intronic chr6:160192266(+) A-I      intronic chr6:160194086(+) A-I      intronic chr6:160193002(+) A-I      intronic chr6:160193732(+) A-I      intronic chr6:160193700(+) A-I      intronic chr6:160191983(+) A-I      intronic chr6:160192041(+) A-I      intronic chr6:160195605(+) A-I      intronic chr6:160193942(+) A-I      intronic chr6:160194069(+) A-I      intronic chr6:160193095(+) A-I      intronic chr6:160193702(+) A-I      intronic chr6:160194138(+) A-I      intronic chr6:160194107(+) A-I      intronic chr6:160192793(+) A-I      intronic chr6:160194072(+) A-I      intronic chr6:160193003(+) A-I      intronic chr6:160194133(+) A-I      intronic chr6:160191682(+) A-I      intronic chr6:160192803(+) A-I      intronic chr6:160195546(+) A-I      intronic chr6:160186525(+) A-I      intronic chr6:160195656(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ACAT2	chr6:160195565(+) A-I intron -    22327324 chr6:160186717(+) C-G intron -    22484847 chr6:160191662(+) A-G intron -    22484847 chr6:160192266(+) A-G intron -    22484847 chr6:160192848(+) A-G intron -    22484847 chr6:160193183(+) A-G intron -    22484847 chr6:160193249(+) A-G intron -    22484847 chr6:160193700(+) A-G intron -    22484847 chr6:160193702(+) A-G intron -    22484847 chr6:160193942(+) A-G intron -    22484847 chr6:160194014(+) A-G intron -    22484847 chr6:160194120(+) A-G intron -    22484847 chr6:160195565(+) A-G intron -    22484847 chr6:160195605(+) A-G intron -    22484847 chr6:160195707(+) A-G intron -    22484847 chr6:160195708(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACAT2	chr6:160181675-160181676(+) m6A 5'UTR       27773535 chr6:160181760-160181761(+) m6A 5'UTR       24284625//27773535 chr6:160181795-160181796(+) m6A 5'UTR       27773535 chr6:160181876-160181877(+) m6A 5'UTR       27773535 chr6:160181894-160181895(+) m6A 5'UTR       27773535 chr6:160181983-160181984(+) m6A 5'UTR       27773535//22608085 chr6:160182292-160182293(+) m6A 5'UTR       27773535//22608085 chr6:160182319-160182320(+) m6A 5'UTR       27773535//22608085 chr6:160182361-160182362(+) m6A 5'UTR       27773535//22608085 chr6:160182366-160182367(+) m6A 5'UTR       27773535//22608085 chr6:160182419-160182420(+) m6A 5'UTR       27773535//22608085 chr6:160182561-160182562(+) m6A 5'UTR       25456834 chr6:160182589-160182590(+) m6A 5'UTR       25456834 chr6:160182610-160182611(+) m6A 5'UTR       25456834 chr6:160182719-160182720(+) m6A 5'UTR       25456834//22608085 chr6:160182764-160182765(+) m6A 5'UTR       25456834 chr6:160183164-160183165(+) m6A CDS       25456834//24981863 chr6:160183534-160183535(+) m6A exon//intron       25456834//24981863 chr6:160188058-160188059(+) m6A CDS//exon       22575960 chr6:160188174-160188175(+) m6A CDS//exon       22575960 chr6:160189566-160189567(+) m6A CDS//exon       27773535 chr6:160196246-160196247(+) m6A CDS//exon       24981863//27773535 chr6:160196270-160196271(+) m6A CDS//exon       27773535 chr6:160196275-160196276(+) m6A CDS//exon       27773535 chr6:160199877-160199878(+) m6A 3'UTR//exon       27773535 chr6:160199898-160199899(+) m6A 3'UTR//exon       27773535 chr6:160199937-160199938(+) m6A 3'UTR//exon       27773535 chr6:160199955-160199956(+) m6A 3'UTR//exon       27773535 chr6:160199976-160199977(+) m6A 3'UTR//exon       27773535 chr6:160200034-160200035(+) m6A 3'UTR//exon       27773535 chr6:160200068-160200069(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548c-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Urine     -
	ACAT2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-548c-5p	Emodin 3220 Drug interaction    RC00007211 Sorafenib 216239 Drug interaction    RC00007212

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-548c-5p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548c-5p
Interactor2: ACAT2

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.