Basic Information:

  VIRBase ID:  

HHID00107962

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548b-5p:  MIMAT0004798          NRG4:  NM_138573     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548b-5p	NRG4
miRBase Accession/Entrez ID	MIMAT0004798	145957
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HRG4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548b-5p	rs1180266201 chr6:119069102    A/G rs1338611711 chr6:119069100    C/T rs188182113 chr6:119069098    G/A rs188182113 chr6:119069098    G/C rs1158490090 chr6:119069118    T/C rs1414502200 chr6:119069112    T/A rs1472929879 chr6:119069115    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NRG4	chr15:76259970(-) A-I      intronic chr15:76259985(-) A-I      intronic chr15:76293441(-) A-I      intronic chr15:76259982(-) A-I      intronic chr15:76259980(-) A-I      intronic chr15:76260070(-) A-I      intronic chr15:76287434(-) A-I      intronic chr15:76241612(-) A-I      intronic chr15:76241284(-) A-I      intronic chr15:76283102(-) A-I      intronic chr15:76241604(-) A-I      intronic chr15:76241714(-) A-I      intronic chr15:76281480(-) A-I      intronic chr15:76283092(-) A-I      intronic chr15:76293624(-) A-I      intronic chr15:76292484(-) A-I      intronic chr15:76241676(-) A-I      intronic chr15:76241700(-) A-I      intronic chr15:76240765(-) A-I      intronic chr15:76246101(-) A-I      intronic chr15:76241689(-) A-I      intronic chr15:76283138(-) A-I      intronic chr15:76241309(-) A-I      intronic chr15:76241536(-) A-I      intronic chr15:76240874(-) A-I      intronic chr15:76245044(-) A-I      intronic chr15:76241640(-) A-I      intronic chr15:76280698(-) A-I      intronic chr15:76283193(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NRG4	chr15:76233371-76233372(-) m6A 3'UTR//intron       24981863//22608085 chr15:76234116-76234117(-) m6A 3'UTR//intron       27773535//22608085 chr15:76234155-76234156(-) m6A 3'UTR//intron       27773535//22608085 chr15:76234408-76234409(-) m6A 3'UTR//intron       27773535 chr15:76234489-76234490(-) m6A 3'UTR//intron       24981863//27773535 chr15:76235206-76235207(-) m6A 3'UTR//intron       27773535 chr15:76235221-76235222(-) m6A 3'UTR//intron       27773535 chr15:76235296-76235297(-) m6A 3'UTR//intron       27773535 chr15:76235392-76235393(-) m6A 3'UTR//intron       24981863//27773535//22575960 chr15:76235398-76235399(-) m6A 3'UTR//intron       24981863//27773535//22575960 chr15:76235525-76235526(-) m6A 3'UTR//intron       24284625//24981863//27773535//22575960 chr15:76235534-76235535(-) m6A 3'UTR//intron       24284625//24981863//27773535//22575960 chr15:76235584-76235585(-) m6A 3'UTR//intron       24284625//24981863//27773535 chr15:76235625-76235626(-) m6A 3'UTR//intron       24284625//24981863//27773535 chr15:76235666-76235667(-) m6A 3'UTR//intron       24284625//27773535//22575960 chr15:76235846-76235847(-) m6A 3'UTR//intron       27773535 chr15:76235921-76235922(-) m6A 3'UTR//exon       27773535 chr15:76235961-76235962(-) m6A 3'UTR//exon       27773535 chr15:76235987-76235988(-) m6A 3'UTR//CDS//exon       27773535 chr15:76238117-76238118(-) m6A exon//intron       27773535 chr15:76238140-76238141(-) m6A exon//intron       27773535 chr15:76243117-76243118(-) m6A intron       27773535 chr15:76243136-76243137(-) m6A intron       27773535 chr15:76243188-76243189(-) m6A intron       27773535 chr15:76243212-76243213(-) m6A intron       27773535 chr15:76243327-76243328(-) m6A intron       27773535 chr15:76243361-76243362(-) m6A intron       27773535 chr15:76303587-76303588(-) m6A 5'UTR       27773535 chr15:76304380-76304381(-) m6A 5'UTR//intron       27773535 chr15:76304385-76304386(-) m6A 5'UTR//intron       27773535 chr15:76304696-76304697(-) m6A 5'UTR//intron       24981863 chr15:76304705-76304706(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548b-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NRG4	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548b-5p
Interactor2: NRG4

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.