Basic Information:

  VIRBase ID:  

HHID00107886

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548b-5p:  MIMAT0004798          CCNB1:  NM_001354844     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-548b-5p	CCNB1
miRBase Accession/Entrez ID	MIMAT0004798	891
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CCNB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-548b-5p	rs1180266201 chr6:119069102    A/G rs1338611711 chr6:119069100    C/T rs188182113 chr6:119069098    G/A rs188182113 chr6:119069098    G/C rs1158490090 chr6:119069118    T/C rs1414502200 chr6:119069112    T/A rs1472929879 chr6:119069115    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCNB1	chr5:68472672(+) A-I      intronic chr5:68468767(+) A-I      intronic chr5:68472802(+) A-I      intronic chr5:68467953(+) A-I      intronic chr5:68472762(+) A-I      intronic chr5:68472695(+) A-I      intronic chr5:68466839(+) A-I      intronic chr5:68465525(+) A-I      intronic chr5:68471534(+) A-I      intronic chr5:68465676(+) A-I      intronic chr5:68469652(+) A-I      intronic chr5:68469758(+) A-I      intronic chr5:68470319(+) A-I      intronic chr5:68468774(+) A-I      intronic chr5:68471550(+) A-I      intronic chr5:68472630(+) A-I      intronic chr5:68472691(+) A-I      intronic chr5:68470429(+) A-I      intronic chr5:68472699(+) A-I      intronic chr5:68472459(+) A-I      intronic chr5:68471977(+) A-I      intronic chr5:68471920(+) A-I      intronic chr5:68470437(+) A-I      intronic chr5:68472727(+) A-I      intronic chr5:68472458(+) A-I      intronic chr5:68472616(+) A-I      intronic chr5:68472599(+) A-I      intronic chr5:68472598(+) A-I      intronic chr5:68472604(+) A-I      intronic chr5:68472685(+) A-I      intronic chr5:68472323(+) A-I      intronic chr5:68472663(+) A-I      intronic chr5:68471917(+) A-I      intronic chr5:68472553(+) A-I      intronic chr5:68470357(+) A-I      intronic chr5:68472379(+) A-I      intronic chr5:68472750(+) A-I      intronic chr5:68472248(+) A-I      intronic chr5:68472597(+) A-I      intronic chr5:68472686(+) A-I      intronic chr5:68472546(+) A-I      intronic chr5:68472605(+) A-I      intronic chr5:68471772(+) A-I      intronic chr5:68471781(+) A-I      intronic chr5:68471898(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCNB1	chr5:68470128(+) A-I exon CDS    19478186 chr5:68472458(+) A-I intron -    22028664 chr5:68472459(+) A-I intron -    22028664 chr5:68472471(+) A-I intron -    22028664 chr5:68472546(+) A-I intron -    22028664 chr5:68472553(+) A-I intron -    22028664 chr5:68472583(+) A-I intron -    22028664 chr5:68472597(+) A-I intron -    22028664 chr5:68472598(+) A-I intron -    22028664 chr5:68472599(+) A-I intron -    22028664 chr5:68472604(+) A-I intron -    22028664 chr5:68472605(+) A-I intron -    22028664 chr5:68472616(+) A-I intron -    22028664 chr5:68472619(+) A-I intron -    22028664 chr5:68472620(+) A-I intron -    22028664 chr5:68472663(+) A-I intron -    22028664 chr5:68472685(+) A-I intron -    22028664 chr5:68472686(+) A-I intron -    22028664 chr5:68472691(+) A-I intron -    22028664 chr5:68472699(+) A-I intron -    22028664 chr5:68472727(+) A-I intron -    22028664 chr5:68470429(+) A-G intron -    22484847 chr5:68470437(+) A-G intron -    22484847 chr5:68472597(+) A-G intron -    22484847 chr5:68472605(+) A-G intron -    22484847 chr5:68472619(+) A-G intron -    22484847 chr5:68472620(+) A-G intron -    22484847 chr5:68472686(+) A-G intron -    22484847 chr5:68472699(+) A-G intron -    22484847 chr5:68472750(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCNB1	chr5:68463124-68463125(+) m6A CDS//intron       22575960 chr5:68463131-68463132(+) m6A CDS//intron       22575960 chr5:68463826-68463827(+) m6A 3'UTR//CDS       24981863//26404942 chr5:68463839-68463840(+) m6A 3'UTR//CDS       24981863//26404942 chr5:68463852-68463853(+) m6A 3'UTR//CDS       24981863 chr5:68463874-68463875(+) m6A 3'UTR//CDS       24981863 chr5:68464007-68464008(+) m6A 3'UTR//CDS       24981863//27773535 chr5:68464040-68464041(+) m6A 3'UTR//CDS       24981863//27773535 chr5:68464049-68464050(+) m6A 3'UTR//CDS       24981863//27773535 chr5:68464112-68464113(+) m6A 3'UTR//CDS       27773535 chr5:68464148-68464149(+) m6A 3'UTR//CDS       26404942 chr5:68470846-68470847(+) m6A CDS       24284625//26404942//27773535//22575960//22608085 chr5:68470878-68470879(+) m6A CDS       24284625//26404942//27773535//22575960//22608085 chr5:68471264-68471265(+) m6A CDS       24284625//27773535//22608085 chr5:68471278-68471279(+) m6A CDS       24284625//27773535//22608085 chr5:68473160-68473161(+) m6A 3'UTR//CDS//exon//intron       27773535 chr5:68473360-68473361(+) m6A 3'UTR//CDS//exon       27773535 chr5:68473465-68473466(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-548b-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CCNB1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-548b-5p
Interactor2: CCNB1

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.