Basic Information:

  VIRBase ID:  

HHID00107846

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-545-3p:  MIMAT0003165          STK38L:  NM_015000     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-545-3p	STK38L
miRBase Accession/Entrez ID	MIMAT0003165	23012
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NDR2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-545-3p	rs1283564708 chrX:74287146    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STK38L	chr12:27465011(+) A-I      intronic chr12:27464952(+) A-I      intronic chr12:27464913(+) A-I      intronic chr12:27428410(+) A-I      intronic chr12:27467187(+) A-I      intronic chr12:27467223(+) A-I      intronic chr12:27466501(+) A-I      intronic chr12:27467245(+) A-I      intronic chr12:27467255(+) A-I      intronic chr12:27424813(+) A-I      intronic chr12:27426941(+) A-I      intronic chr12:27465965(+) A-I      intronic chr12:27427065(+) A-I      intronic chr12:27428346(+) A-I      intronic chr12:27428377(+) A-I      intronic chr12:27428396(+) A-I      intronic chr12:27454317(+) A-I      intronic chr12:27454318(+) A-I      intronic chr12:27454321(+) A-I      intronic chr12:27427059(+) A-I      intronic chr12:27454322(+) A-I      intronic chr12:27454394(+) A-I      intronic chr12:27454400(+) A-I      intronic chr12:27454405(+) A-I      intronic chr12:27454454(+) A-I      intronic chr12:27455734(+) A-I      intronic chr12:27455784(+) A-I      intronic chr12:27455803(+) A-I      intronic chr12:27455839(+) A-I      intronic chr12:27456931(+) A-I      intronic chr12:27456993(+) A-I      intronic chr12:27465927(+) A-I      intronic chr12:27466030(+) A-I      intronic chr12:27466536(+) A-I      intronic chr12:27466551(+) A-I      intronic chr12:27467079(+) A-I      intronic chr12:27467105(+) A-I      intronic chr12:27467109(+) A-I      intronic chr12:27467120(+) A-I      intronic chr12:27467148(+) A-I      intronic chr12:27415985(+) A-I      intronic chr12:27415534(+) A-I      intronic chr12:27467299(+) A-I      intronic chr12:27467305(+) A-I      intronic chr12:27415540(+) A-I      intronic chr12:27415571(+) A-I      intronic chr12:27415633(+) A-I      intronic chr12:27415763(+) A-I      intronic chr12:27415871(+) A-I      intronic chr12:27415958(+) A-I      intronic chr12:27466389(+) A-I      intronic chr12:27422715(+) A-I      intronic chr12:27422845(+) A-I      intronic chr12:27422856(+) A-I      intronic chr12:27423540(+) A-I      intronic chr12:27424694(+) A-I      intronic chr12:27424762(+) A-I      intronic chr12:27424772(+) A-I      intronic chr12:27465997(+) A-I      intronic chr12:27428453(+) A-I      intronic chr12:27466392(+) A-I      intronic chr12:27440132(+) A-I      intronic chr12:27441067(+) A-I      intronic chr12:27466358(+) A-I      intronic chr12:27457107(+) A-I      intronic chr12:27459861(+) A-I      intronic chr12:27447203(+) A-I      intronic chr12:27415831(+) A-I      intronic chr12:27466018(+) A-I      intronic chr12:27466060(+) A-I      intronic chr12:27415836(+) A-I      intronic chr12:27451200(+) A-I      intronic chr12:27415511(+) A-I      intronic chr12:27440998(+) A-I      intronic chr12:27466464(+) A-I      intronic chr12:27447768(+) A-I      intronic chr12:27455685(+) A-I      intronic chr12:27447773(+) A-I      intronic chr12:27457013(+) A-I      intronic chr12:27428456(+) A-I      intronic chr12:27454331(+) A-I      intronic chr12:27415817(+) A-I      intronic chr12:27466590(+) A-I      intronic chr12:27457007(+) A-I      intronic chr12:27466454(+) A-I      intronic chr12:27451265(+) A-I      intronic chr12:27451133(+) A-I      intronic chr12:27447901(+) A-I      intronic chr12:27466499(+) A-I      intronic chr12:27415531(+) A-I      intronic chr12:27467133(+) A-I      intronic chr12:27415587(+) A-I      intronic chr12:27447365(+) A-I      intronic chr12:27466481(+) A-I      intronic chr12:27451261(+) A-I      intronic chr12:27465918(+) A-I      intronic chr12:27466513(+) A-I      intronic chr12:27473261(+) A-I      intronic chr12:27467213(+) A-I      intronic chr12:27424822(+) A-I      intronic chr12:27420300(+) A-I      intronic chr12:27428452(+) A-I      intronic chr12:27415783(+) A-I      intronic chr12:27459864(+) A-I      intronic chr12:27422797(+) A-I      intronic chr12:27466027(+) A-I      intronic chr12:27415832(+) A-I      intronic chr12:27466480(+) A-I      intronic chr12:27403785(+) A-I      intronic chr12:27447710(+) A-I      intronic chr12:27464877(+) A-I      intronic chr12:27456933(+) A-I      intronic chr12:27457112(+) A-I      intronic chr12:27466588(+) A-I      intronic chr12:27466021(+) A-I      intronic chr12:27454461(+) A-I      intronic chr12:27428381(+) A-I      intronic chr12:27415563(+) A-I      intronic chr12:27447877(+) A-I      intronic chr12:27428546(+) A-I      intronic chr12:27457017(+) A-I      intronic chr12:27467259(+) A-I      intronic chr12:27464997(+) A-I      intronic chr12:27467244(+) A-I      intronic chr12:27415553(+) A-I      intronic chr12:27459774(+) A-I      intronic chr12:27466319(+) A-I      intronic chr12:27467275(+) A-I      intronic chr12:27415782(+) A-I      intronic chr12:27447191(+) A-I      intronic chr12:27467100(+) A-I      intronic chr12:27424816(+) A-I      intronic chr12:27451146(+) A-I      intronic chr12:27466568(+) A-I      intronic chr12:27451225(+) A-I      intronic chr12:27466444(+) A-I      intronic chr12:27466070(+) A-I      intronic chr12:27459697(+) A-I      intronic chr12:27466456(+) A-I      intronic chr12:27451330(+) A-I      intronic chr12:27415495(+) A-I      intronic chr12:27447180(+) A-I      intronic chr12:27466126(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STK38L	chr12:27451133(+) A-I intron -    15258596 chr12:27451146(+) A-I intron -    15258596 chr12:27451200(+) A-I intron -    15258596 chr12:27476394(+) T-G intron -    21725310 chr12:27478128(+) A-C intron -    21725310 chr12:27415563(+) A-G intron -    22484847 chr12:27466027(+) A-G intron -    22484847 chr12:27466060(+) A-G intron -    22484847 chr12:27466126(+) A-G intron -    22484847 chr12:27466358(+) A-G intron -    22484847 chr12:27466454(+) A-G intron -    22484847 chr12:27467259(+) A-G intron -    22484847 chr12:27467275(+) A-G intron -    22484847 chr12:27400768(+) G-T intron -    22484847 chr12:27403785(+) A-G intron -    22484847 chr12:27403950(+) G-A intron -    22484847 chr12:27415495(+) A-G intron -    22484847 chr12:27415511(+) A-G intron -    22484847 chr12:27415531(+) A-G intron -    22484847 chr12:27415553(+) A-G intron -    22484847 chr12:27415587(+) A-G intron -    22484847 chr12:27415783(+) A-G intron -    22484847 chr12:27415817(+) A-G intron -    22484847 chr12:27415831(+) A-G intron -    22484847 chr12:27415832(+) A-G intron -    22484847 chr12:27415877(+) G-A intron -    22484847 chr12:27422797(+) A-G intron -    22484847 chr12:27424816(+) A-G intron -    22484847 chr12:27424822(+) A-G intron -    22484847 chr12:27426943(+) C-T intron -    22484847 chr12:27428452(+) A-G intron -    22484847 chr12:27428453(+) A-G intron -    22484847 chr12:27428456(+) A-G intron -    22484847 chr12:27447174(+) T-C intron -    22484847 chr12:27447180(+) A-G intron -    22484847 chr12:27447203(+) A-G intron -    22484847 chr12:27447365(+) A-G intron -    22484847 chr12:27447901(+) A-G intron -    22484847 chr12:27451225(+) A-G intron -    22484847 chr12:27451265(+) A-G intron -    22484847 chr12:27454331(+) A-G intron -    22484847 chr12:27454461(+) A-G intron -    22484847 chr12:27459692(+) T-A intron -    22484847 chr12:27464877(+) A-G intron -    22484847 chr12:27464997(+) A-G intron -    22484847 chr12:27465918(+) A-G intron -    22484847 chr12:27465992(+) T-C intron -    22484847 chr12:27465997(+) A-G intron -    22484847 chr12:27466018(+) A-G intron -    22484847 chr12:27466021(+) A-G intron -    22484847 chr12:27466070(+) A-G intron -    22484847 chr12:27466392(+) A-G intron -    22484847 chr12:27466456(+) A-G intron -    22484847 chr12:27466464(+) A-G intron -    22484847 chr12:27466481(+) A-G intron -    22484847 chr12:27466499(+) A-G intron -    22484847 chr12:27466513(+) A-G intron -    22484847 chr12:27466568(+) A-G intron -    22484847 chr12:27467244(+) A-G intron -    22484847 chr12:27467353(+) G-A intron -    22484847 chr12:27471752(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STK38L	chr12:27450782-27450783(+) m6A CDS//exon       24981863 chr12:27450808-27450809(+) m6A exon//intron       24981863 chr12:27450853-27450854(+) m6A exon//intron       24981863 chr12:27461307-27461308(+) m6A 3'UTR//CDS//intron       24981863 chr12:27461331-27461332(+) m6A 3'UTR//CDS//intron       24981863 chr12:27461336-27461337(+) m6A 3'UTR//CDS//intron       24981863 chr12:27470286-27470287(+) m6A 3'UTR//CDS       24981863 chr12:27470322-27470323(+) m6A 3'UTR//CDS       24981863 chr12:27470939-27470940(+) m6A 3'UTR//CDS//exon       24981863 chr12:27472280-27472281(+) m6A 3'UTR//CDS//exon       24981863 chr12:27475276-27475277(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475281-27475282(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475296-27475297(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475419-27475420(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr12:27475538-27475539(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr12:27475637-27475638(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27475712-27475713(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27475742-27475743(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27476030-27476031(+) m6A 3'UTR       27773535 chr12:27476550-27476551(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-545-3p	Exosome Brain tissue     23382797 Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	STK38L	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-545-3p	Iodine Green 9956454 Drug sensitive Sensorad 99342 Drug sensitive Midostaurin 9829523 Drug resistant Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive L-2-Aminobutyric acid 80283 Drug sensitive Sulbentine 67686 Drug sensitive Ixabepilone 6445540 Drug sensitive trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive Artelasticin 5471311 Drug sensitive 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive Indanthren Corinth RK 5351878 Drug sensitive 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive Vorinostat 5311 Drug sensitive 8-Hydroxymanzamine A 5270765 Drug sensitive Spiperone 5265 Drug resistant 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Propyl gallate 4947 Drug resistant Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive Triciribine phosphate 43860 Drug resistant Di-n-octyl-secalonsaure A 430141 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive 2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive Leflunomide 3899 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant 4,5-Dimethyl-11H-pyrido[4,3-a]carbazole 382590 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Maxima isoflavone D 343081 Drug sensitive Predorine 333830 Drug sensitive Rustaiyan A 324967 Drug sensitive Bromocriptine 31101 Drug sensitive Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive Prumycin HCl 24197905 Drug resistant Drostanolone propionate 224004 Drug sensitive Kinetin riboside 20345 Drug resistant Sudan II 18386 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug sensitive Antineoplastic-633273 15954131 Drug sensitive Astrazon Orange R 135747272 Drug sensitive (2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant tp4ek - Drug resistant (z) 3,3',4,5-tetramethoxystilbene - Drug sensitive (z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive 1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive antineoplastic-615538 - Drug sensitive antineoplastic-641296 - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive isatin dr - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-545-3p	D-Glucose 5793 Drug interaction    RC00005847 Doxorubicin 31703 Drug interaction    RC00005848 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005846 Verapamil 2520 Drug interaction    RC00005845 Chemotherapy - Drug interaction    RC00008874

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-545-3p
Interactor2: STK38L

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.