Detail Information

Basic Information:


  VIRBase ID:  

HHID00107834

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-545-3p:           MAP3K7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-545-3p MAP3K7
miRBase
Accession/Entrez ID		 MIMAT0003165 6885
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CSCF//FMD2//MEKK7//TAK1//TGF1a

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-545-3p
rs1283564708 chrX:74287146    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MAP3K7
chr6:91285975(-) A-I      intronic
chr6:91288122(-) A-I      intronic
chr6:91288126(-) A-I      intronic
chr6:91296044(-) A-I      intronic
chr6:91292687(-) A-I      intronic
chr6:91285994(-) A-I      intronic
chr6:91285993(-) A-I      intronic
chr6:91286079(-) A-I      intronic
chr6:91288030(-) A-I      intronic
chr6:91288057(-) A-I      intronic
chr6:91288158(-) A-I      intronic
chr6:91288187(-) A-I      intronic
chr6:91288189(-) A-I      intronic
chr6:91288197(-) A-I      intronic
chr6:91288213(-) A-I      intronic
chr6:91290290(-) A-I      intronic
chr6:91290311(-) A-I      intronic
chr6:91292605(-) A-I      intronic
chr6:91292694(-) A-I      intronic
chr6:91295902(-) A-I      intronic
chr6:91296045(-) A-I      intronic
chr6:91288164(-) A-I      intronic
chr6:91296028(-) A-I      intronic
chr6:91285973(-) A-I      intronic
chr6:91290318(-) A-I      intronic
chr6:91241421(-) A-I      intronic
chr6:91286020(-) A-I      intronic
chr6:91290312(-) A-I      intronic
chr6:91292833(-) A-I      intronic
chr6:91288131(-) A-I      intronic
chr6:91237189(-) A-I      intronic
chr6:91288190(-) A-I      intronic
chr6:91241427(-) A-I      intronic
chr6:91288132(-) A-I      intronic
chr6:91285961(-) A-I      intronic
chr6:91241527(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MAP3K7
chr6:91288236(-) A-I intron -    21960545
chr6:91235141(-) G-T intron -    22484847
chr6:91241421(-) A-G intron -    22484847
chr6:91285961(-) A-G intron -    22484847
chr6:91286020(-) A-G intron -    22484847
chr6:91286095(-) A-G intron -    22484847
chr6:91288131(-) A-G intron -    22484847
chr6:91288132(-) A-G intron -    22484847
chr6:91288152(-) G-A intron -    22484847
chr6:91288190(-) A-G intron -    22484847
chr6:91288236(-) A-G intron -    22484847
chr6:91290318(-) A-G intron -    22484847
chr6:91292833(-) A-G intron -    22484847
chr6:91254873(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MAP3K7
chr6:91225007-91225008(-) m6A 3'UTR       27773535
chr6:91225016-91225017(-) m6A 3'UTR       27773535
chr6:91225060-91225061(-) m6A 3'UTR       27773535//22608085
chr6:91225249-91225250(-) m6A 3'UTR       24981863//27773535//22608085
chr6:91225286-91225287(-) m6A 3'UTR       24981863//27773535//22608085
chr6:91225417-91225418(-) m6A 3'UTR//exon       27773535
chr6:91225476-91225477(-) m6A 3'UTR//exon       27773535
chr6:91225537-91225538(-) m6A 3'UTR//exon       27773535
chr6:91225547-91225548(-) m6A 3'UTR//exon       27773535
chr6:91225573-91225574(-) m6A 3'UTR//exon       27773535
chr6:91225654-91225655(-) m6A 3'UTR//exon       27773535//22608085
chr6:91225713-91225714(-) m6A 3'UTR//exon       27773535//22608085
chr6:91225764-91225765(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr6:91225848-91225849(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr6:91225879-91225880(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr6:91225897-91225898(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr6:91225911-91225912(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr6:91225959-91225960(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr6:91225972-91225973(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:91226048-91226049(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr6:91226156-91226157(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:91226179-91226180(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:91226209-91226210(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr6:91226270-91226271(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr6:91226307-91226308(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr6:91226330-91226331(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr6:91226361-91226362(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr6:91226376-91226377(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr6:91226381-91226382(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr6:91226393-91226394(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr6:91228193-91228194(-) m6A CDS//exon//intron       24284625//27773535//22608085
chr6:91228233-91228234(-) m6A CDS//exon//intron       27773535
chr6:91228261-91228262(-) m6A CDS//exon//intron       27773535
chr6:91233414-91233415(-) m6A CDS//exon       27773535
chr6:91233451-91233452(-) m6A CDS//exon       27773535
chr6:91246064-91246065(-) m6A CDS//exon       27773535
chr6:91246069-91246070(-) m6A CDS//exon       27773535
chr6:91246086-91246087(-) m6A CDS//exon       27773535
chr6:91246112-91246113(-) m6A CDS//exon       27773535
chr6:91263221-91263222(-) Gm CDS       -
chr6:91296709-91296710(-) m6A 5'UTR       24981863//27371828//27773536
chr6:91296761-91296762(-) m6A 5'UTR       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-545-3p
Exosome Brain tissue     23382797
Exosome Serum     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
MAP3K7
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-545-3p
Iodine Green 9956454 Drug sensitive
Sensorad 99342 Drug sensitive
Midostaurin 9829523 Drug resistant
Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
Sulbentine 67686 Drug sensitive
Ixabepilone 6445540 Drug sensitive
trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Artelasticin 5471311 Drug sensitive
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Thiram 5455 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
Vorinostat 5311 Drug sensitive
8-Hydroxymanzamine A 5270765 Drug sensitive
Spiperone 5265 Drug resistant
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Propyl gallate 4947 Drug resistant
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
Triciribine phosphate 43860 Drug resistant
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive
Leflunomide 3899 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
4,5-Dimethyl-11H-pyrido[4,3-a]carbazole 382590 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Predorine 333830 Drug sensitive
Rustaiyan A 324967 Drug sensitive
Bromocriptine 31101 Drug sensitive
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
Prumycin HCl 24197905 Drug resistant
Drostanolone propionate 224004 Drug sensitive
Kinetin riboside 20345 Drug resistant
Sudan II 18386 Drug sensitive
Butyltriphenylphosphonium bromide 159628 Drug sensitive
Antineoplastic-633273 15954131 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
tp4ek - Drug resistant
(z) 3,3',4,5-tetramethoxystilbene - Drug sensitive
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
1h-1,4,7-triazonine-1,4-diacetic acid, octahydro- - Drug sensitive
1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
(Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
antineoplastic-641296 - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
isatin dr - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-545-3p
D-Glucose 5793 Drug interaction    RC00005847
Doxorubicin 31703 Drug interaction    RC00005848
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005846
Verapamil 2520 Drug interaction    RC00005845
Chemotherapy - Drug interaction    RC00008874

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-545-3p
Interactor2: MAP3K7

Evidence Support:


Prediction-Evidence miRDB
Support Database ViRBase

References:


PMID 33201341 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.

Starting a new search, please wait ...