Basic Information:

  VIRBase ID:  

HHID00106569

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          PRDM1:  NM_182907     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	PRDM1
miRBase Accession/Entrez ID	MIMAT0000245	639
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BLIMP1//PRDI-BF1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRDM1	chr6:106552182(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PRDM1	chr6:106542634(+) T-C intron -    22484847 chr6:106552182(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRDM1	chr6:106534217-106534218(+) m6A 5'UTR       - chr6:106534339-106534340(+) m6A 5'UTR       24209618//22575960 chr6:106534397-106534398(+) m6A 5'UTR//intron       24209618 chr6:106534417-106534418(+) m6A 5'UTR//intron       24209618 chr6:106535741-106535742(+) m6A 5'UTR//intron       - chr6:106535748-106535749(+) m6A 5'UTR//intron       - chr6:106535762-106535763(+) m6A 5'UTR//intron       - chr6:106536129-106536130(+) m6A 5'UTR//CDS       - chr6:106536138-106536139(+) m6A 5'UTR//CDS       - chr6:106536151-106536152(+) m6A CDS       - chr6:106536180-106536181(+) m6A CDS       - chr6:106547304-106547305(+) m6A CDS//exon       - chr6:106547347-106547348(+) m6A CDS//exon       24981863 chr6:106547370-106547371(+) m6A CDS//exon       24284625//24981863 chr6:106547443-106547444(+) m6A exon//intron       24284625//24981863 chr6:106547488-106547489(+) m6A exon//intron       24981863 chr6:106547557-106547558(+) m6A exon//intron       24981863 chr6:106547573-106547574(+) m6A exon//intron       24981863 chr6:106552704-106552705(+) m6A CDS       24981863//22575960 chr6:106552745-106552746(+) m6A CDS       24284625//24209618//24981863//22575960 chr6:106552804-106552805(+) m6A CDS       24284625//24209618//24981863//22575960 chr6:106552828-106552829(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr6:106552870-106552871(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr6:106552957-106552958(+) m6A CDS       24284625//24209618//24981863//22575960 chr6:106552994-106552995(+) m6A CDS       24284625//24209618//24981863 chr6:106553149-106553150(+) m6A CDS       24284625//24209618//24981863 chr6:106554907-106554908(+) m6A CDS       24981863//22575960 chr6:106554966-106554967(+) m6A CDS       24209618//25456834//24981863//22575960 chr6:106555008-106555009(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr6:106555190-106555191(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr6:106555218-106555219(+) m6A CDS       24209618//25456834//24981863//22575960 chr6:106555231-106555232(+) m6A CDS       24209618//25456834//24981863//22575960 chr6:106555330-106555331(+) m6A CDS       24209618//25456834//24981863//22575960 chr6:106555337-106555338(+) m6A CDS       24209618//24981863//22575960 chr6:106555345-106555346(+) m6A CDS       24209618//24981863//22575960 chr6:106555373-106555374(+) m6A 3'UTR       24209618//24981863//22575960 chr6:106555507-106555508(+) m6A 3'UTR       24981863//22575960 chr6:106555538-106555539(+) m6A 3'UTR       24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	PRDM1	Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: PRDM1

Evidence Support:

Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	33201341	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	By custom target prediction, a panel of miRNA sequences able to recognize the SARS-CoV-2 sequence was collected. Only targets with a very high score (95-100) were retained for further analyses.