Basic Information:

  VIRBase ID:  

HHID00105414

  Virus:  

SARS-CoV-2

  Host:  

Mus musculus

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-200c-5p:  MIMAT0004663          Ace2:  NM_001130513     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-200c-5p	Ace2
miRBase Accession/Entrez ID	MIMAT0004663	70008
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	2010305L05Rik

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-200c-5p
Interactor2: Ace2

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	32891636	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	Neonatal rat cardiomyocytes	Interactor2 expression	Downregulation
Description	Collectively, these data suggest that cardiomyocytes are probably the major cell type which expresses ACE2 in the heart and miR-429, 200b and -200c may present as promising targets to regulate ACE2 expression.