Basic Information:

  VIRBase ID:  

HHID00105411

  Virus:  

SARS-CoV-2

  Host:  

Mus musculus

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-200c-3p:  MIMAT0000657          Ace2:  NM_001130513     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-200c-3p	Ace2
miRBase Accession/Entrez ID	MIMAT0000657	70008
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	2010305L05Rik

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-200c-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome Serum     28160157 Exosome B6 BMDCs     22031862 Mitochondrion Hippocampus     25562527 Synaptoneurosome ForeBrain     18410515

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-200c-3p
Interactor2: Ace2

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	32891636	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	Neonatal rat cardiomyocytes	Interactor2 expression	Downregulation
Description	Collectively, these data suggest that cardiomyocytes are probably the major cell type which expresses ACE2 in the heart and miR-429, 200b and -200c may present as promising targets to regulate ACE2 expression.