Detail Information

Basic Information:


  VIRBase ID:  

HHID00105399

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2483

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-98-3p:           TMPRSS2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-98-3p TMPRSS2
miRBase
Accession/Entrez ID		 MIMAT0022842 7113
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PRSS10

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-98-3p
rs1209516675 chrX:53556253    A/C
rs1214041940 chrX:53556243    G/C
rs1280441583 chrX:53556251    TA/T
rs1486410746 chrX:53556250    G/T
rs1556934591 chrX:53556243    G/GA
rs782515496 chrX:53556241    G/A
rs1277087629 chrX:53556260    T/A
rs1277087629 chrX:53556260    T/C
rs1312190088 chrX:53556257    GTATAGT/G
rs1556934616 chrX:53556257    G/A
rs1556934642 chrX:53556261    A/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMPRSS2
chr21:42853862(-) A-I      intronic
chr21:42853848(-) A-I      intronic
chr21:42853888(-) A-I      intronic
chr21:42853850(-) A-I      intronic
chr21:42853879(-) A-I      intronic
chr21:42857482(-) A-I      intronic
chr21:42857493(-) A-I      intronic
chr21:42857494(-) A-I      intronic
chr21:42857532(-) A-I      intronic
chr21:42861840(-) A-I      intronic
chr21:42863176(-) A-I      intronic
chr21:42863181(-) A-I      intronic
chr21:42864020(-) A-I      intronic
chr21:42857454(-) A-I      intronic
chr21:42852821(-) A-I      intronic
chr21:42852811(-) A-I      intronic
chr21:42868840(-) A-I      intronic
chr21:42864037(-) A-I      intronic
chr21:42852802(-) A-I      intronic
chr21:42852784(-) A-I      intronic
chr21:42852783(-) A-I      intronic
chr21:42852698(-) A-I      intronic
chr21:42868853(-) A-I      intronic
chr21:42853773(-) A-I      intronic
chr21:42853747(-) A-I      intronic
chr21:42852838(-) A-I      intronic
chr21:42868879(-) A-I      intronic
chr21:42853786(-) A-I      intronic
chr21:42853787(-) A-I      intronic
chr21:42853866(-) A-I      intronic
chr21:42853876(-) A-I      intronic
chr21:42853901(-) A-I      intronic
chr21:42853902(-) A-I      intronic
chr21:42853905(-) A-I      intronic
chr21:42853936(-) A-I      intronic
chr21:42857436(-) A-I      intronic
chr21:42852837(-) A-I      intronic
chr21:42852694(-) A-I      intronic
chr21:42857467(-) A-I      intronic
chr21:42857468(-) A-I      intronic
chr21:42857476(-) A-I      intronic
chr21:42859902(-) A-I      ncRNA
chr21:42859884(-) A-I      ncRNA
chr21:42859893(-) A-I      ncRNA
chr21:42868835(-) A-I      intronic
chr21:42859992(-) A-I      intronic
chr21:42855936(-) A-I      intronic
chr21:42868944(-) A-I      intronic
chr21:42868836(-) A-I      intronic
chr21:42852668(-) A-I      intronic
chr21:42859993(-) A-I      intronic
chr21:42869010(-) A-I      intronic
chr21:42863353(-) A-I      intronic
chr21:42868900(-) A-I      intronic
chr21:42868945(-) A-I      intronic
chr21:42852703(-) A-I      intronic
chr21:42860827(-) A-I      intronic
chr21:42859858(-) A-I      ncRNA
chr21:42859831(-) A-I      ncRNA
chr21:42859844(-) A-I      ncRNA
chr21:42858403(-) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMPRSS2
chr21:42858403(-) A-I intron -    15342557
chr21:42858406(-) A-I intron -    15342557
chr21:42859670(-) A-I intron -    15342557
chr21:42859831(-) A-I intron -    15342557   //15258596
chr21:42859844(-) A-I intron -    15342557   //15258596
chr21:42859858(-) A-I intron -    15342557   //15258596
chr21:42859884(-) A-I intron -    15342557   //15258596
chr21:42859893(-) A-I intron -    15342557   //15258596
chr21:42859902(-) A-I intron -    15342557   //15258596
chr21:42868835(-) A-I intron -    15342557
chr21:42868836(-) A-I intron -    15342557
chr21:42868864(-) A-I intron -    15342557
chr21:42868900(-) A-I intron -    15342557
chr21:42868905(-) A-I intron -    15342557
chr21:42868944(-) A-I intron -    15342557
chr21:42868945(-) A-I intron -    15342557
chr21:42868950(-) A-I intron -    15342557
chr21:42869010(-) A-I intron -    15342557
chr21:42869014(-) A-I intron -    15342557
chr21:42869073(-) A-I intron -    15342557
chr21:42853823(-) A-I intron -    21960545
chr21:42853826(-) A-I intron -    21960545
chr21:42853866(-) A-I intron -    21960545
chr21:42855839(-) A-I intron -    21960545
chr21:42855936(-) A-I intron -    21960545
chr21:42855984(-) A-I intron -    21960545
chr21:42857419(-) A-I intron -    21960545
chr21:42857454(-) A-I intron -    21960545
chr21:42857468(-) A-I intron -    21960545
chr21:42857493(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMPRSS2
chr21:42836773-42836774(-) m6A 3'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-98-3p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
TMPRSS2
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-98-3p
Interactor2: TMPRSS2

Evidence Support:


Prediction-Evidence miRanda//miRBase//miRDB//miRWalk//Targetscan
Support Database ViRBase

References:


[1]PMID 32992681 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Table 2 shows a list of novel potential candidate miRNAs against TMPRSS2 gene which were not studied previously.
[2]PMID 33359190 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Albeit, list of putative miRNAs (11 miRNAs) retrieved as result from all the three prediction tools is represented in Fig. 2f.

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