Basic Information:

  VIRBase ID:  

HHID00105384

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2499

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4458:  MIMAT0018980          TMPRSS2:  NM_001135099     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4458	TMPRSS2
miRBase Accession/Entrez ID	MIMAT0018980	7113
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRSS10

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4458	rs1412148153 chr5:8460934    G/C rs1474483700 chr5:8460935    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMPRSS2	chr21:42853862(-) A-I      intronic chr21:42853848(-) A-I      intronic chr21:42853888(-) A-I      intronic chr21:42853850(-) A-I      intronic chr21:42853879(-) A-I      intronic chr21:42857482(-) A-I      intronic chr21:42857493(-) A-I      intronic chr21:42857494(-) A-I      intronic chr21:42857532(-) A-I      intronic chr21:42861840(-) A-I      intronic chr21:42863176(-) A-I      intronic chr21:42863181(-) A-I      intronic chr21:42864020(-) A-I      intronic chr21:42857454(-) A-I      intronic chr21:42852821(-) A-I      intronic chr21:42852811(-) A-I      intronic chr21:42868840(-) A-I      intronic chr21:42864037(-) A-I      intronic chr21:42852802(-) A-I      intronic chr21:42852784(-) A-I      intronic chr21:42852783(-) A-I      intronic chr21:42852698(-) A-I      intronic chr21:42868853(-) A-I      intronic chr21:42853773(-) A-I      intronic chr21:42853747(-) A-I      intronic chr21:42852838(-) A-I      intronic chr21:42868879(-) A-I      intronic chr21:42853786(-) A-I      intronic chr21:42853787(-) A-I      intronic chr21:42853866(-) A-I      intronic chr21:42853876(-) A-I      intronic chr21:42853901(-) A-I      intronic chr21:42853902(-) A-I      intronic chr21:42853905(-) A-I      intronic chr21:42853936(-) A-I      intronic chr21:42857436(-) A-I      intronic chr21:42852837(-) A-I      intronic chr21:42852694(-) A-I      intronic chr21:42857467(-) A-I      intronic chr21:42857468(-) A-I      intronic chr21:42857476(-) A-I      intronic chr21:42859902(-) A-I      ncRNA chr21:42859884(-) A-I      ncRNA chr21:42859893(-) A-I      ncRNA chr21:42868835(-) A-I      intronic chr21:42859992(-) A-I      intronic chr21:42855936(-) A-I      intronic chr21:42868944(-) A-I      intronic chr21:42868836(-) A-I      intronic chr21:42852668(-) A-I      intronic chr21:42859993(-) A-I      intronic chr21:42869010(-) A-I      intronic chr21:42863353(-) A-I      intronic chr21:42868900(-) A-I      intronic chr21:42868945(-) A-I      intronic chr21:42852703(-) A-I      intronic chr21:42860827(-) A-I      intronic chr21:42859858(-) A-I      ncRNA chr21:42859831(-) A-I      ncRNA chr21:42859844(-) A-I      ncRNA chr21:42858403(-) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMPRSS2	chr21:42858403(-) A-I intron -    15342557 chr21:42858406(-) A-I intron -    15342557 chr21:42859670(-) A-I intron -    15342557 chr21:42859831(-) A-I intron -    15342557   //15258596 chr21:42859844(-) A-I intron -    15342557   //15258596 chr21:42859858(-) A-I intron -    15342557   //15258596 chr21:42859884(-) A-I intron -    15342557   //15258596 chr21:42859893(-) A-I intron -    15342557   //15258596 chr21:42859902(-) A-I intron -    15342557   //15258596 chr21:42868835(-) A-I intron -    15342557 chr21:42868836(-) A-I intron -    15342557 chr21:42868864(-) A-I intron -    15342557 chr21:42868900(-) A-I intron -    15342557 chr21:42868905(-) A-I intron -    15342557 chr21:42868944(-) A-I intron -    15342557 chr21:42868945(-) A-I intron -    15342557 chr21:42868950(-) A-I intron -    15342557 chr21:42869010(-) A-I intron -    15342557 chr21:42869014(-) A-I intron -    15342557 chr21:42869073(-) A-I intron -    15342557 chr21:42853823(-) A-I intron -    21960545 chr21:42853826(-) A-I intron -    21960545 chr21:42853866(-) A-I intron -    21960545 chr21:42855839(-) A-I intron -    21960545 chr21:42855936(-) A-I intron -    21960545 chr21:42855984(-) A-I intron -    21960545 chr21:42857419(-) A-I intron -    21960545 chr21:42857454(-) A-I intron -    21960545 chr21:42857468(-) A-I intron -    21960545 chr21:42857493(-) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMPRSS2	chr21:42836773-42836774(-) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4458	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TMPRSS2	Exosome Blood     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4458
Interactor2: TMPRSS2

Evidence Support:

Prediction-Evidence	microT//miRanda//miRBase//miRMap//miRWalk//PicTar//PITA//Targetscan
Support Database	ViRBase

References:

[1]PMID	33428154	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

[2]PMID	32992681	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Table 2 shows a list of novel potential candidate miRNAs against TMPRSS2 gene which were not studied previously.

[3]PMID	32814446	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Considering the significance of ACE2 and TMPRSS2 in SARS-CoV-2 infection, we also performed a TargetScan (http://www.targetscan.org/vert_72/) search for the miRNAs that could target these two receptors, and the analysis revealed a list of miRNAs such as, hsa-miRNA 200b-3p, hsa-miRNA 200c-3p and miRNA 429 for ACE2, and hsa-let 7c-5p, hsa-miRNA 98-5p, hsa-let 7f-5p, hsa-let 7a-5p, hsa-let 7g-5p, hsa-let 7b-5p, hsa-miRNA 4458, hsa-let 7e-5p, hsa-let 7i-5p, hsa-let 7d-5p, and hsa-miRNA 4500 for TMPRSS2.