Basic Information:

  VIRBase ID:  

HHID00105372

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9639

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1976:  MIMAT0009451          PIK3CG:  NM_002649     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1976	PIK3CG
miRBase Accession/Entrez ID	MIMAT0009451	5294
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	p110gamma//p120-PI3K//PI3CG//PI3K//PI3Kgamma//PIK3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1976	rs1173366847 chr1:26554586    C/T rs1208235584 chr1:26554592    G/A rs985342579 chr1:26554590    C/T rs1478358767 chr1:26554578    C/T rs765589931 chr1:26554577    C/G rs972150493 chr1:26554576    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIK3CG	chr7:106521177(+) A-I      intronic chr7:106521175(+) A-I      intronic chr7:106522298(+) A-I      intronic chr7:106522108(+) A-I      intronic chr7:106522037(+) A-I      intronic chr7:106521227(+) A-I      intronic chr7:106517396(+) A-I      intronic chr7:106517442(+) A-I      intronic chr7:106517457(+) A-I      intronic chr7:106521250(+) A-I      intronic chr7:106522106(+) A-I      intronic chr7:106521257(+) A-I      intronic chr7:106522215(+) A-I      intronic chr7:106521160(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIK3CG	chr7:106516354(+) G-T intron -    22484847 chr7:106521250(+) A-G intron -    22484847 chr7:106521257(+) A-G intron -    22484847 chr7:106521326(+) A-G intron -    22484847 chr7:106522106(+) A-G intron -    22484847 chr7:106522215(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIK3CG	chr7:106508246-106508247(+) m6A CDS//intron       - chr7:106508262-106508263(+) m6A CDS//intron       - chr7:106508281-106508282(+) m6A CDS//intron       - chr7:106508357-106508358(+) m6A CDS//intron       - chr7:106508364-106508365(+) m6A CDS//intron       - chr7:106508806-106508807(+) m6A CDS//intron       - chr7:106508871-106508872(+) m6A CDS//intron       25456834 chr7:106508928-106508929(+) m6A CDS//intron       25456834 chr7:106508940-106508941(+) m6A CDS//intron       25456834 chr7:106509039-106509040(+) m6A CDS//intron       - chr7:106509072-106509073(+) m6A CDS//intron       - chr7:106509132-106509133(+) m6A CDS//intron       - chr7:106509162-106509163(+) m6A CDS//intron       - chr7:106509483-106509484(+) m6A CDS//intron       - chr7:106509508-106509509(+) m6A CDS//intron       - chr7:106509531-106509532(+) m6A CDS//intron       - chr7:106509540-106509541(+) m6A CDS//intron       - chr7:106509567-106509568(+) m6A CDS//intron       - chr7:106509627-106509628(+) m6A CDS//intron       - chr7:106509717-106509718(+) m6A CDS//intron       - chr7:106509802-106509803(+) m6A CDS//intron       - chr7:106509824-106509825(+) m6A CDS//intron       - chr7:106509900-106509901(+) m6A CDS//intron       - chr7:106509946-106509947(+) m6A CDS//intron       - chr7:106545807-106545808(+) m6A CDS       - chr7:106545819-106545820(+) m6A CDS       - chr7:106545853-106545854(+) m6A 3'UTR       - chr7:106545897-106545898(+) m6A 3'UTR       - chr7:106545919-106545920(+) m6A 3'UTR       - chr7:106545967-106545968(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1976	Cytoplasm Cell line (HeLa)     21695135 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Mitochondrion Skeletal muscle cells     27563705
	PIK3CG	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1976	Gemcitabine 60750 Drug interaction    RC00007973 5-Fluorouracil 3385 Drug interaction    RC00007972

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1976	Panobinostat       6918837 Paclitaxel       36314

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1976
Interactor2: PIK3CG

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	DIANA//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	33675361	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	SUM-1315 cells	Interactor2 expression	Upregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.