Basic Information:

  VIRBase ID:  

HHID00105341

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-543:  MIMAT0004954          ACE2:  NM_021804     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-543	ACE2
miRBase Accession/Entrez ID	MIMAT0004954	59272
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACEH

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-543	rs542214199 chr14:101032044    G/A rs757050688 chr14:101032049    CT/C rs759929657 chr14:101032048    A/G rs759929657 chr14:101032048    A/T rs760890689 chr14:101032042    C/T rs761909359 chr14:101032033    A/G rs766725704 chr14:101032043    G/A rs773362858 chr14:101032041    G/A rs1033402586 chr14:101032035    A/T rs772064768 chr14:101032040    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACE2	chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535 chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535 chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535 chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535 chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535 chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535 chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535 chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-543	Exosome Plasma     23663360 Exosome Blood     - Microvesicle Blood|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	ACE2	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-543	8-Aminoadenosine 96851 Drug resistant 1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug resistant Berberine iodide 72350 Drug sensitive Silver mesylate 6712944 Drug resistant Pyrazolo[1,5-b]pyridazine deriv. 97 6539439 Drug resistant Crotonoside 65085 Drug resistant 2-Azaadenine 5480214 Drug resistant 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive [(1H-Benzimidazole-2-yl)dithio]-9H-purine 54613148 Drug resistant 2-Methylolivacinium acetate 5458752 Drug sensitive Xestin A 5352066 Drug resistant Vorinostat 5311 Drug resistant Pyrimethamine 4993 Drug resistant 6-Bromosangivamycin 470030 Drug resistant Justicidin B 442882 Drug resistant Suavedol 442245 Drug resistant Musennin 441933 Drug sensitive Antibiotic X-14766A 434840 Drug sensitive Elliptinium acetate 42722 Drug sensitive Carboplatin 426756 Drug sensitive Uracil, 3-methyl-6-(phenylhydrazino)- 385874 Drug resistant 2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive 1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant Haloprogin 3561 Drug resistant p-Bromophenacyl benzoate 345792 Drug resistant Maxima isoflavone D 343081 Drug sensitive Ellipticine 3213 Drug sensitive 8-Trichloromethyldihydroberberine 320713 Drug sensitive 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive 4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant Sarcoviolin 24202820 Drug sensitive Kinetin riboside 20345 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant Jolkinolide B 161954 Drug resistant [(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant Methyl ester prodigiosene 136040158 Drug resistant Acid Alizarine Red B 135565636 Drug sensitive Formycin b 135449281 Drug resistant Salicylidene salicylhydrazide 135445765 Drug resistant 43-Dioxypectenotoxin 131751434 Drug sensitive Litmomycin 12310334 Drug resistant 2-(p-nitrophenoxy)carbonyl-1,2-dihydroellipticine - Drug resistant ethyl, methoxy, prodigisine - Drug resistant inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant bafilomycin antibiotic - Drug resistant granatomycin a - Drug resistant 1,4-bis(n-cysteinyldiethylamino)-5,8-dihydroxy anthraquinon - Drug sensitive phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive 2-methylellpticinium - Drug sensitive Annamycin Liposomal - Drug sensitive protein: pahiv4 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-543	10-Hydroxycamptothecin 97226 Drug interaction    RC00007450 Oxaliplatine 6857599 Drug interaction    RC00007452 Cholecalciferol 5280795 Drug interaction    RC00007451 5-Fluorouracil 3385 Drug interaction    RC00007449 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007448 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00007453 Benzene 241 Drug interaction    RC00007447 Leucovorin 135403648 Drug interaction    RC00007454

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-543	l-685,458       5479543 Sorafenib       216239 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-543
Interactor2: ACE2

Evidence Support:

Prediction-Evidence	miRanda//miRBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32992681	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Table 1 shows a list of novel potential candidate miRNAs against ACE2 gene that were not studied previously.