Basic Information:

  VIRBase ID:  

HHID00105338

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9070

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-665:  MIMAT0004952          IL6:  NM_001318095     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-665	IL6
miRBase Accession/Entrez ID	MIMAT0004952	3569
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-665	rs1161003917 chr14:100875086    G/A rs1203257535 chr14:100875094    T/C rs1251413334 chr14:100875092    C/T rs1321122076 chr14:100875089    G/T rs1374122857 chr14:100875088    G/A rs759481457 chr14:100875093    C/G rs1201625296 chr14:100875078    A/G rs1490584325 chr14:100875079    G/C rs747741348 chr14:100875077    C/G rs747741348 chr14:100875077    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL6	chr7:22770700(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL6	chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       - chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-665	Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome K562 cells     24460325 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Mesenchymal stem cells|Urine     -
	IL6	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Serum     - Nucleus HeLa-S3 cells     - Polysome HeLa cells     26000482

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-665
Interactor2: IL6

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//qRT-PCR
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase

References:

PMID	33675361	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	Adipose-derived stem cells	Interactor2 expression	Downregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.