Basic Information:

  VIRBase ID:  

HHID00105333

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-300:  MIMAT0004903          ACE2:  NM_021804     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-300	ACE2
miRBase Accession/Entrez ID	MIMAT0004903	59272
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACEH

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-300	rs1031942581 chr14:101041414    T/C rs1167187017 chr14:101041427    ACTCT/ACT rs1167187017 chr14:101041427    ACTCT/A rs1249302051 chr14:101041426    G/A rs770337971 chr14:101041433    TCTGGGGAGCAAATC/T rs776907252 chr14:101041430    C/G rs1209976831 chr14:101041421    G/C rs1209976831 chr14:101041421    G/T rs747491462 chr14:101041419    A/C rs747491462 chr14:101041419    A/G rs771323440 chr14:101041418    C/T rs780443253 chr14:101041417    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACE2	chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535 chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535 chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535 chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535 chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535 chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535 chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535 chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-300	Exosome Serum     18589210 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ACE2	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-300	Vincristine 5978 Drug interaction    RC00007314 Mitomycin 5746 Drug interaction    RC00007313 Carboplatinum 38904 Drug interaction    RC00007316 Doxorubicin 31703 Drug interaction    RC00007315 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007312 Tamoxifen 2733526 Drug interaction    RC00007318 Lenalidomide 216326 Drug interaction    RC00007317

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-300	Irinotecan       60838

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-300
Interactor2: ACE2

Evidence Support:

Prediction-Evidence	miRanda//miRBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32992681	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Table 1 shows a list of novel potential candidate miRNAs against ACE2 gene that were not studied previously.