Detail Information

Basic Information:


  VIRBase ID:  

HHID00105326

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-502-3p:           DHODH:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-502-3p DHODH
miRBase
Accession/Entrez ID		 MIMAT0004775 1723
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DHOdehase//POADS//URA1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-502-3p
rs1557183235 chrX:50014657    T/C
rs1557183236 chrX:50014658    G/A
rs781957096 chrX:50014669    C/T
rs782397209 chrX:50014666    A/C
rs1206203216 chrX:50014650    A/C
rs1206203216 chrX:50014650    A/G
rs1448298437 chrX:50014651    T/C
rs1557183232 chrX:50014651    T/TA
rs1557183233 chrX:50014653    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DHODH
chr16:72058675(+) A-I      3'UTR
chr16:72053020(+) A-I      intronic
chr16:72058716(+) A-I      3'UTR
chr16:72058737(+) A-I      3'UTR
chr16:72058725(+) A-I      3'UTR
chr16:72058705(+) A-I      3'UTR
chr16:72058689(+) A-I      3'UTR
chr16:72051562(+) A-I      intronic
chr16:72058652(+) A-I      3'UTR
chr16:72058850(+) A-I      3'UTR
chr16:72058691(+) A-I      3'UTR
chr16:72058690(+) A-I      3'UTR
chr16:72058647(+) A-I      3'UTR
chr16:72058741(+) A-I      3'UTR
chr16:72058620(+) A-I      3'UTR
chr16:72055845(+) A-I      intronic
chr16:72055871(+) A-I      intronic
chr16:72053107(+) A-I      intronic
chr16:72054388(+) A-I      intronic
chr16:72053808(+) A-I      intronic
chr16:72055841(+) A-I      intronic
chr16:72053922(+) A-I      intronic
chr16:72058717(+) A-I      3'UTR
chr16:72045336(+) A-I      intronic
chr16:72054440(+) A-I      intronic
chr16:72051860(+) A-I      intronic
chr16:72054064(+) A-I      intronic
chr16:72043882(+) A-I      intronic
chr16:72044899(+) A-I      intronic
chr16:72045309(+) A-I      intronic
chr16:72052984(+) A-I      intronic
chr16:72054512(+) A-I      intronic
chr16:72053813(+) A-I      intronic
chr16:72052972(+) A-I      intronic
chr16:72051880(+) A-I      intronic
chr16:72054013(+) A-I      intronic
chr16:72054157(+) A-I      intronic
chr16:72054068(+) A-I      intronic
chr16:72054100(+) A-I      intronic
chr16:72045399(+) A-I      intronic
chr16:72054087(+) A-I      intronic
chr16:72054486(+) A-I      intronic
chr16:72052955(+) A-I      intronic
chr16:72053777(+) A-I      intronic
chr16:72053786(+) A-I      intronic
chr16:72055698(+) A-I      intronic
chr16:72052924(+) A-I      intronic
chr16:72052934(+) A-I      intronic
chr16:72055956(+) A-I      intronic
chr16:72054331(+) A-I      intronic
chr16:72054055(+) A-I      intronic
chr16:72043899(+) A-I      intronic
chr16:72058721(+) A-I      3'UTR
chr16:72058757(+) A-I      3'UTR
chr16:72058709(+) A-I      3'UTR
chr16:72058748(+) A-I      3'UTR
chr16:72058753(+) A-I      3'UTR
chr16:72058856(+) A-I      3'UTR
chr16:72058711(+) A-I      3'UTR
chr16:72058612(+) A-I      3'UTR
chr16:72058715(+) A-I      3'UTR
chr16:72058714(+) A-I      3'UTR
chr16:72058611(+) A-I      3'UTR
chr16:72058780(+) A-I      3'UTR
chr16:72058818(+) A-I      3'UTR
chr16:72058702(+) A-I      3'UTR
chr16:72058817(+) A-I      3'UTR
chr16:72058747(+) A-I      3'UTR
chr16:72058774(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DHODH
chr16:72052933(+) A-I intron -    22327324
chr16:72058817(+) A-I intron -    22327324
chr16:72051567(+) T-C intron -    22484847
chr16:72052933(+) T-C intron -    22484847
chr16:72053790(+) T-C intron -    22484847
chr16:72053808(+) A-G intron -    22484847
chr16:72054055(+) A-G intron -    22484847
chr16:72054064(+) A-G intron -    22484847
chr16:72054068(+) A-G intron -    22484847
chr16:72054393(+) T-C intron -    22484847
chr16:72054399(+) T-C intron -    22484847
chr16:72054440(+) A-G intron -    22484847
chr16:72055870(+) T-C intron -    22484847
chr16:72058611(+) A-G intron -    22484847
chr16:72058711(+) A-G intron -    22484847
chr16:72058748(+) A-G intron -    22484847
chr16:72058817(+) A-G intron -    22484847
chr16:72058818(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DHODH
chr16:72042634-72042635(+) m6A 5'UTR       24981863
chr16:72042674-72042675(+) m6A CDS       24981863
chr16:72042717-72042718(+) m6A 5'UTR//intron       24981863
chr16:72042724-72042725(+) m6A 5'UTR//intron       24981863
chr16:72042768-72042769(+) m6A 5'UTR//intron       24981863
chr16:72043014-72043015(+) m6A 5'UTR//intron       25456834//24981863
chr16:72043025-72043026(+) m6A 5'UTR//intron       25456834//24981863
chr16:72045989-72045990(+) m6A 5'UTR//CDS       25456834//24981863
chr16:72046043-72046044(+) m6A CDS       25456834
chr16:72046075-72046076(+) m6A CDS       -
chr16:72048454-72048455(+) m6A 3'UTR//CDS//exon       24981863
chr16:72048505-72048506(+) m6A 3'UTR//CDS//exon       24981863
chr16:72049772-72049773(+) m6A exon//intron       27773535
chr16:72050541-72050542(+) m6A exon//intron       27773535
chr16:72050958-72050959(+) m6A 3'UTR//CDS//exon       24981863
chr16:72050976-72050977(+) m6A 3'UTR//CDS//exon       24981863
chr16:72056351-72056352(+) m6A CDS//intron       24284625
chr16:72057091-72057092(+) m6A CDS//exon//intron       24284625
chr16:72057514-72057515(+) m6A CDS//exon//intron       24284625//24209618//22608085
chr16:72058100-72058101(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr16:72058129-72058130(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr16:72058141-72058142(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr16:72058180-72058181(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr16:72058285-72058286(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:72058292-72058293(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:72058299-72058300(+) Y 3'UTR//exon       26075521
chr16:72058321-72058322(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:72058348-72058349(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr16:72058398-72058399(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr16:72058504-72058505(+) m6A 3'UTR       24981863
chr16:72058554-72058555(+) m6A 3'UTR       24981863
chr16:72058577-72058578(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-502-3p
Exosome B cell line (Raji)|Primary dendritic cells     21505438
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Blood     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
DHODH
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-502-3p
Interactor2: DHODH

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HCT116 cells Interactor2 expression Downregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

Starting a new search, please wait ...