Detail Information

Basic Information:


  VIRBase ID:  

HHID00105323

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9812

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-500a-5p:           HDAC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-500a-5p HDAC2
miRBase
Accession/Entrez ID		 MIMAT0004773 3066
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HD2//KDAC2//RPD3//YAF1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-500a-5p
rs1221490724 chrX:50008465    A/G
rs1557181893 chrX:50008443    T/G
rs1557181895 chrX:50008452    C/G
rs1557181897 chrX:50008453    T/A
rs1557181900 chrX:50008458    G/A
rs1557181900 chrX:50008458    G/C
rs1557181904 chrX:50008463    A/T
rs369176381 chrX:50008450    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HDAC2
chr6:114265700(-) A-I      intronic
chr6:114265806(-) A-I      intronic
chr6:114265703(-) A-I      intronic
chr6:114265885(-) A-I      intronic
chr6:114284316(-) A-I      intronic
chr6:114284339(-) A-I      intronic
chr6:114284385(-) A-I      intronic
chr6:114284515(-) A-I      intronic
chr6:114284512(-) A-I      intronic
chr6:114257976(-) A-I      3'UTR
chr6:114257971(-) A-I      3'UTR
chr6:114258008(-) A-I      3'UTR
chr6:114258007(-) A-I      3'UTR
chr6:114257997(-) A-I      3'UTR
chr6:114257993(-) A-I      3'UTR
chr6:114287552(-) A-I      intronic
chr6:114284537(-) A-I      intronic
chr6:114287633(-) A-I      intronic
chr6:114284016(-) A-I      intronic
chr6:114271767(-) A-I      intronic
chr6:114283880(-) A-I      intronic
chr6:114286598(-) A-I      intronic
chr6:114265930(-) A-I      intronic
chr6:114258032(-) A-I      3'UTR
chr6:114288360(-) A-I      intronic
chr6:114288389(-) A-I      intronic
chr6:114284276(-) A-I      intronic
chr6:114284451(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED HDAC2
chr6:114261880(-) T-A exon 3'UTR    21725310
chr6:114283943(-) A-G intron -    22484847
chr6:114284016(-) A-G intron -    22484847
chr6:114284537(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HDAC2
chr6:114259443-114259444(-) m6A 3'UTR       27773535
chr6:114259464-114259465(-) m6A 3'UTR       27773535
chr6:114260979-114260980(-) m6A 3'UTR       27773535
chr6:114261964-114261965(-) m6A 3'UTR//exon       27773535
chr6:114262113-114262114(-) m6A 3'UTR//exon       24981863//27773535
chr6:114262147-114262148(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr6:114262239-114262240(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114262884-114262885(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114262901-114262902(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114264517-114264518(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114264525-114264526(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114264532-114264533(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114264657-114264658(-) m6A CDS//exon       24981863//27773535
chr6:114265457-114265458(-) m6A CDS//exon       24981863//27773535
chr6:114265487-114265488(-) m6A CDS//exon       24981863
chr6:114279852-114279853(-) m6A CDS//exon       24981863//26404942
chr6:114292187-114292188(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-500a-5p
Exosome Primary dendritic cells     21505438
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
HDAC2
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-500a-5p
Interactor2: HDAC2

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Weak-Evidence Microarray
Prediction-Evidence miRanda//miRTP//RNA22//Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Colorectal cancer tissues//LoVo cells Interactor2 expression Downregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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