Basic Information:

  VIRBase ID:  

HHID00105322

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-488-3p:  MIMAT0004763          TLR9:  NM_017442     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-488-3p	TLR9
miRBase Accession/Entrez ID	MIMAT0004763	54106
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD289

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-488-3p	rs1248997320 chr1:177029376    C/T rs1310911055 chr1:177029378    A/G rs1210074726 chr1:177029388    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR9	chr3:52255247-52255248(-) m6A CDS       28052920 chr3:52255260-52255261(-) m6A CDS       28052920 chr3:52255284-52255285(-) m6A CDS       28052920 chr3:52255449-52255450(-) m6A CDS       27371828 chr3:52255509-52255510(-) m6A CDS       - chr3:52255566-52255567(-) m6A CDS       - chr3:52255579-52255580(-) m6A CDS       - chr3:52255677-52255678(-) m6A CDS       - chr3:52255806-52255807(-) m6A CDS       28052920 chr3:52255881-52255882(-) m6A CDS       28052920//27371828 chr3:52255917-52255918(-) m6A CDS       28052920//27371828 chr3:52256016-52256017(-) m6A CDS       - chr3:52256109-52256110(-) m6A CDS       - chr3:52256116-52256117(-) m6A CDS       - chr3:52256392-52256393(-) m6A CDS       - chr3:52256418-52256419(-) m6A CDS       - chr3:52256430-52256431(-) m6A CDS       - chr3:52256478-52256479(-) m6A CDS       - chr3:52256520-52256521(-) m6A CDS       - chr3:52256937-52256938(-) m6A CDS       - chr3:52256955-52256956(-) m6A CDS       - chr3:52256976-52256977(-) m6A CDS       - chr3:52257060-52257061(-) m6A CDS       - chr3:52257069-52257070(-) m6A CDS       - chr3:52257129-52257130(-) m6A CDS       - chr3:52257148-52257149(-) m6A CDS       - chr3:52257187-52257188(-) m6A CDS       - chr3:52257222-52257223(-) m6A CDS       - chr3:52257615-52257616(-) m6A CDS       - chr3:52257629-52257630(-) m6A CDS       - chr3:52257786-52257787(-) m6A CDS       - chr3:52257855-52257856(-) m6A CDS       - chr3:52257945-52257946(-) m6A CDS       - chr3:52258041-52258042(-) m6A CDS       - chr3:52258200-52258201(-) m6A CDS       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-488-3p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Cerebrospinal fluid     24797360 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Nucleus Nasopharyngeal carcinoma cells     20498841
	TLR9	Chromatin K562 cells     - Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-488-3p	D-Glucose 5793 Drug interaction    RC00007146 Diethylstilbestrol 448537 Drug interaction    RC00007148 Doxorubicin 31703 Drug interaction    RC00007147 Chemotherapy - Drug interaction    RC00008884

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-488-3p	Cisplatin 5702198       28328082

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-488-3p
Interactor2: TLR9

Evidence Support:

Prediction-Evidence	microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database	ViRBase

References:

PMID	33428154	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.