Detail Information

Basic Information:


  VIRBase ID:  

HHID00105317

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-340-5p:           TLR3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-340-5p TLR3
miRBase
Accession/Entrez ID		 MIMAT0004692 7098
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD283//IIAE2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-340-5p
rs1028729442 chr5:180015373    T/G
rs1163577212 chr5:180015361    A/C
rs1266382195 chr5:180015365    AG/A
rs1177339324 chr5:180015380    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TLR3
chr4:187001863(+) A-I      intronic
chr4:187003336(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TLR3
chr4:186990367-186990368(+) m6A 5'UTR       24981863
chr4:186997778-186997779(+) m6A CDS       24981863
chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003978-187003979(+) m6A CDS//exon       24981863
chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863
chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863
chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863
chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004635-187004636(+) m6A CDS//exon       24981863
chr4:187004686-187004687(+) m6A CDS//exon       24981863
chr4:187004746-187004747(+) m6A CDS//exon       24981863
chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863
chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863
chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863
chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863
chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863
chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863
chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863
chr4:187005310-187005311(+) m6A CDS//exon       24981863
chr4:187005888-187005889(+) m6A CDS//exon       24981863
chr4:187005893-187005894(+) m6A CDS//exon       24981863
chr4:187005944-187005945(+) m6A CDS//exon       24981863
chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-340-5p
Exosome Serum     29143228
Exosome Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Breast milk|Endothelial cells|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
TLR3
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-340-5p
Tetrangulol 99188 Drug sensitive
Midostaurin 9829523 Drug resistant
2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive
1,9-Pyrazoloanthrone 8515 Drug resistant
L-2-Aminobutyric acid 80283 Drug sensitive
Coptisine chloride 72321 Drug sensitive
7-Hydroxystaurosporine 72271 Drug resistant
Tolonium chloride 7083 Drug sensitive
Azure B 68275 Drug sensitive
4H-Furo(3,2-g)(1)benzopyran-4,7,9-trione 68083 Drug sensitive
Melicopidine 68060 Drug sensitive
Sulbentine 67686 Drug sensitive
Laurolinium acetate 67354 Drug sensitive
NO Data IN this field 6711510 Drug sensitive
Indazole analogue 17 6539599 Drug sensitive
Ixabepilone 6445540 Drug sensitive
Methylene blue 6099 Drug sensitive
Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
Caracemide 54747 Drug sensitive
11-Cyanomethylen-11H-indolo[1,2-a]indazole 5472501 Drug resistant
(Z)-4-Bromo-4-iodo-3-phenylbut-3-en-2-one 5467656 Drug sensitive
Herveline O 5459269 Drug sensitive
Dysorone E 5459221 Drug sensitive
Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive
Thiram 5455 Drug sensitive
(E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
Centaureidin 5315773 Drug sensitive
Peridinin 5289155 Drug sensitive
Plumericin 5281545 Drug sensitive
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive
1-[2-(3-Chlorophenyl)-2-oxoethyl]-2-acetylbenzimidazole 46911792 Drug sensitive
4-(5'-Bromofuran-2'-yl)-3-bromo-but-3-en-2-one 45028185 Drug sensitive
Latrunculin a 445420 Drug resistant
Griseofulvin 441140 Drug sensitive
2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug sensitive
5-(Chloromethyl)quinolin-8-ol 416881 Drug sensitive
Chelocardin dodecyl sulfate 415844 Drug resistant
1H-Naphth[2,3-d]imidazole, 2-[(4-chlorophenyl)methyl]- 405626 Drug resistant
Menadione 4055 Drug sensitive
2-S-Dimethylarsino-2-thiobenzoic acid 404813 Drug sensitive
Kuanoniamine A 390989 Drug sensitive
2-(1-Propynyl)estradiol 388008 Drug sensitive
Sampangine 387195 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Chloro-3-(1-(4-methyl)piperazino)naphthazarin 378627 Drug sensitive
N-(8-Hydroxy-6-methyl-1,4-dioxo-1,4-dihydro-2-naphthalenyl)acetamide 377214 Drug sensitive
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug sensitive
5,8-Dihydroxy-2-(4-(2-pyridinyl)-1-piperazinyl)naphthoquinone 376947 Drug sensitive
(1R)-3,3-Dibromocamphor 376765 Drug sensitive
Cycloalkannin 375418 Drug sensitive
1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug resistant
3-Nitro-5-formylisoxazole 362479 Drug sensitive
Girolline 362388 Drug resistant
4H-1-Benzothiopyran-4-one, 2-(methylsulfinyl)- 360259 Drug sensitive
Thiosangivamycin 3580213 Drug sensitive
Haloprogin 3561 Drug sensitive
1-Chloro-3-(3-chloropropylsulfonylsulfanyl)propane 355643 Drug sensitive
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive
Maxima isoflavone D 343081 Drug sensitive
Buellolide 337850 Drug sensitive
Bis(helenalinyl)glutarate 336831 Drug sensitive
Helenin 327378 Drug sensitive
Rustaiyan A 324967 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug sensitive
Phenanthrene-9,10-diimine 2981 Drug sensitive
(15S)-15-Ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one 2724040 Drug sensitive
D-Arabinose, 5-O-trityl-tribenzoate 265952 Drug sensitive
Solacongestidine 258526 Drug sensitive
3,6-Dibromophenanthrene-9,10-dione 258450 Drug sensitive
Noformicin 251919 Drug resistant
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
Antibiotic U 29135 24196291 Drug sensitive
Cytembena 23665583 Drug sensitive
Scillirosidin, glycoside 222160 Drug sensitive
5-Nitroso-8-hydroxyquinoline 19103 Drug sensitive
2,2-Diethyl-6-(hydroxymethyl)-4,6,7,7a-tetrahydro-3aH-[1,3,2]dioxastannolo[4,5-c]pyran-4,7-diol 16683462 Drug sensitive
(6R)-1,6,11-Trihydroxy-8-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-methyl-5,6-dihydrobenzo[a]anthracene-7,12-dione 15507920 Drug sensitive
Amphethinile 146332 Drug sensitive
[(1R,5R)-16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate 146159135 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Discorhabdin B 135409044 Drug sensitive
Methyl (1S,10R,11S,12S)-11-acetyloxy-12-ethyl-4-[(13R,15R,17R)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 133126830 Drug sensitive
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug sensitive
Berberine chloride 12456 Drug sensitive
Benzoanthracenone 12300036 Drug resistant
Pepleo 122804 Drug resistant
Melampodinin 11953936 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
Cyanoaminopyranopyridine derivatives 11494577 Drug resistant
(5S,7S)-5,7,9,10-Tetrahydroxy-2-methoxy-7-methyl-6,8-dihydro-5H-anthracene-1,4-dione 11209399 Drug sensitive
1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole 11162021 Drug resistant
Fusariotoxin T-2 102515111 Drug sensitive
Capri Blue 102162 Drug sensitive
15,16-Dihydrocuracin A 101683509 Drug sensitive
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive
Chimaphilin 101211 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
3-peg fudr (peg floxuridine) - Drug resistant
toxin .delta.53l - Drug resistant
tp4ek-k6 - Drug resistant
(E)-6-chloro-3-((2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methylene)indolin-2-one - Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive
1-piperidinecarbodithioic acid, antimony complex - Drug sensitive
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
5-[2-(4-methoxyphenyl)ethyl]-1,2,3-dimethoxy benzene - Drug sensitive
7h-5,6-dithioleno[4,3-d]uracil - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-phenyl- - Drug sensitive
aquatris(1,3-diphenylpropane-1,3-dionato)neodymium(iii) - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug sensitive
benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2,5-diacetyl- - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
gold(1+), bis(trimethylphosphine)-, chloride - Drug sensitive
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
uridine, 5-isobutyl-2'-deoxy- - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
2-(1-(2-fluorophenylsulfonyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide - Drug sensitive
2-(1-(4-chlorophenylsulfonyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide - Drug sensitive
2-oxo-N-(pyridin-4-yl)-2-(1-tosyl-1H-indol-3-yl)acetamide - Drug sensitive
3-farnesylthiopropionamide - Drug sensitive
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
antineoplastic-625577 - Drug sensitive
chlorambucil-spermidine - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
dolavaline - Drug sensitive
geldanamycin analog - Drug sensitive
geldanamycin-11-hexadecanic acid ester - Drug sensitive
phenylmercuric acetate (usan) - Drug sensitive
rh(iii)-amodiaquine - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-340-5p
5-Fluorouracil 3385 Drug interaction    RC00007078
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007077
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00007081
Docetaxel 148124 Drug interaction    RC00007080
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-340-5p
Cisplatin 5702198       28443990
Docetaxel 148124       30300682

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-340-5p
Interactor2: TLR3

Evidence Support:


Prediction-Evidence microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database ViRBase

References:


PMID 33428154 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

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