Basic Information:

  VIRBase ID:  

HHID00105310

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-200c-5p:  MIMAT0004657          LDHA:  NR_028500     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-200c-5p	LDHA
miRBase Accession/Entrez ID	MIMAT0004657	3939
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GSD11//HEL-S-133P//LDHM//PIG19

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-200c-5p	rs1220589670 chr12:6963703    C/T rs1277597787 chr12:6963716    A/C rs372372905 chr12:6963719    G/A rs942672545 chr12:6963713    A/G rs1318673559 chr12:6963704    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LDHA	chr11:18419235(+) A-I      intronic chr11:18426267(+) A-I      intronic chr11:18427630(+) A-I      intronic chr11:18427710(+) A-I      intronic chr11:18427735(+) A-I      intronic chr11:18428068(+) A-I      intronic chr11:18428077(+) A-I      intronic chr11:18428103(+) A-I      intronic chr11:18428152(+) A-I      intronic chr11:18428188(+) A-I      intronic chr11:18425890(+) A-I      intronic chr11:18428352(+) A-I      intronic chr11:18425850(+) A-I      intronic chr11:18420336(+) A-I      intronic chr11:18427587(+) A-I      intronic chr11:18419186(+) A-I      intronic chr11:18428062(+) A-I      intronic chr11:18427696(+) A-I      intronic chr11:18425791(+) A-I      intronic chr11:18425643(+) A-I      intronic chr11:18426192(+) A-I      intronic chr11:18428120(+) A-I      intronic chr11:18428414(+) A-I      intronic chr11:18428088(+) A-I      intronic chr11:18426193(+) A-I      intronic chr11:18426189(+) A-I      intronic chr11:18426178(+) A-I      intronic chr11:18425897(+) A-I      intronic chr11:18425796(+) A-I      intronic chr11:18428418(+) A-I      intronic chr11:18425577(+) A-I      intronic chr11:18425541(+) A-I      intronic chr11:18426195(+) A-I      intronic chr11:18420363(+) A-I      intronic chr11:18419104(+) A-I      intronic chr11:18425497(+) A-I      intronic chr11:18419192(+) A-I      intronic chr11:18426208(+) A-I      intronic chr11:18419966(+) A-I      intronic chr11:18420326(+) A-I      intronic chr11:18420287(+) A-I      intronic chr11:18420278(+) A-I      intronic chr11:18428419(+) A-I      intronic chr11:18419315(+) A-I      intronic chr11:18428102(+) A-I      intronic chr11:18419278(+) A-I      intronic chr11:18427612(+) A-I      intronic chr11:18419179(+) A-I      intronic chr11:18419142(+) A-I      intronic chr11:18420327(+) A-I      intronic chr11:18425659(+) A-I      intronic chr11:18425617(+) A-I      intronic chr11:18425595(+) A-I      intronic chr11:18428078(+) A-I      intronic chr11:18428143(+) A-I      intronic chr11:18425542(+) A-I      intronic chr11:18420346(+) A-I      intronic chr11:18419117(+) A-I      intronic chr11:18420262(+) A-I      intronic chr11:18420422(+) A-I      intronic chr11:18425794(+) A-I      intronic chr11:18419087(+) A-I      intronic chr11:18425501(+) A-I      intronic chr11:18427613(+) A-I      intronic chr11:18420423(+) A-I      intronic chr11:18428456(+) A-I      intronic chr11:18427933(+) A-I      intronic chr11:18428080(+) A-I      intronic chr11:18419283(+) A-I      intronic chr11:18419181(+) A-I      intronic chr11:18427606(+) A-I      intronic chr11:18428108(+) A-I      intronic chr11:18427687(+) A-I      intronic chr11:18419201(+) A-I      intronic chr11:18427693(+) A-I      intronic chr11:18420368(+) A-I      intronic chr11:18425797(+) A-I      intronic chr11:18425662(+) A-I      intronic chr11:18420530(+) A-I      intronic chr11:18419312(+) A-I      intronic chr11:18421206(+) A-I      intronic chr11:18427642(+) A-I      intronic chr11:18421177(+) A-I      intronic chr11:18421150(+) A-I      intronic chr11:18425813(+) A-I      intronic chr11:18427553(+) A-I      intronic chr11:18428410(+) A-I      intronic chr11:18427895(+) A-I      intronic chr11:18428468(+) A-I      intronic chr11:18425644(+) A-I      intronic chr11:18427997(+) A-I      intronic chr11:18425619(+) A-I      intronic chr11:18425800(+) A-I      intronic chr11:18419120(+) A-I      intronic chr11:18427652(+) A-I      intronic chr11:18420518(+) A-I      intronic chr11:18428366(+) A-I      intronic chr11:18425582(+) A-I      intronic chr11:18427535(+) A-I      intronic chr11:18427715(+) A-I      intronic chr11:18428449(+) A-I      intronic chr11:18425902(+) A-I      intronic chr11:18425499(+) A-I      intronic chr11:18428945(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LDHA	chr11:18428945(+) A-I intron -    21960545 chr11:18419117(+) A-G intron -    22484847 chr11:18419201(+) A-G intron -    22484847 chr11:18425791(+) A-G intron -    22484847 chr11:18426093(+) T-C intron -    22484847 chr11:18427652(+) A-G intron -    22484847 chr11:18428143(+) A-G intron -    22484847 chr11:18428366(+) A-G intron -    22484847 chr11:18428414(+) A-G intron -    22484847 chr11:18428418(+) A-G intron -    22484847 chr11:18428456(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LDHA	chr11:18418320-18418321(+) m6A 5'UTR//intron       24981863 chr11:18418436-18418437(+) m6A CDS//exon       27773535 chr11:18418586-18418587(+) m6A exon//intron       22575960 chr11:18421070-18421071(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18422077-18422078(+) Gm exon//intron       - chr11:18422482-18422483(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18422527-18422528(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18424434-18424435(+) m6A 3'UTR//CDS//exon//intron       22575960 chr11:18424543-18424544(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr11:18425284-18425285(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr11:18425305-18425306(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr11:18425322-18425323(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr11:18427013-18427014(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr11:18427043-18427044(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr11:18428716-18428717(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18428733-18428734(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18428944-18428945(+) m6A 3'UTR//exon       27773535 chr11:18428954-18428955(+) m6A 3'UTR//exon       27773535 chr11:18429172-18429173(+) m6A 3'UTR//exon       27773535//22575960 chr11:18429280-18429281(+) m6A 3'UTR//exon       27773535 chr11:18429331-18429332(+) m6A 3'UTR       27773535 chr11:18429369-18429370(+) m6A 3'UTR       27773535 chr11:18429380-18429381(+) m6A 3'UTR       27773535 chr11:18429387-18429388(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-200c-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	LDHA	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-200c-5p
Interactor2: LDHA

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//RT-qPCR//Western blot
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase

References:

PMID	33675361	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	A549 cells//NCI-H460 cells//16HBE cells	Interactor2 expression	Downregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.