Basic Information:

  VIRBase ID:  

HHID00105296

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9642

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-297:  MIMAT0004450          SIGMAR1:  NR_104108     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-297	SIGMAR1
miRBase Accession/Entrez ID	MIMAT0004450	10280
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALS16//DSMA2//hSigmaR1//OPRS1//SIG-1R//sigma1R//SR-BP//SR-BP1//SRBP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-297	rs112636147 chr4:110860629    A/G rs1178786327 chr4:110860624    C/T rs1308294147 chr4:110860628    C/T rs1311419982 chr4:110860644    T/C rs574662005 chr4:110860634    C/T rs750616026 chr4:110860632    T/G rs761952094 chr4:110860626    T/C rs765617048 chr4:110860627    G/A rs766797585 chr4:110860633    G/GCACATT rs780526713 chr4:110860635    A/G rs1220881742 chr4:110860636    CACAT/C rs1296788843 chr4:110860638    C/T rs1299039069 chr4:110860640    T/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SIGMAR1	chr9:34634890-34634891(-) m6A 3'UTR       27773535 chr9:34634915-34634916(-) m6A 3'UTR       27773535 chr9:34634966-34634967(-) m6A 3'UTR       27773535 chr9:34635269-34635270(-) m6A 3'UTR       24284625//26404942//27773535 chr9:34635344-34635345(-) m6A 3'UTR       24284625//26404942//27773535 chr9:34635409-34635410(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr9:34635427-34635428(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr9:34635445-34635446(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr9:34635454-34635455(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr9:34635464-34635465(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr9:34635472-34635473(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr9:34635537-34635538(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr9:34635543-34635544(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr9:34635595-34635596(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr9:34635607-34635608(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr9:34635635-34635636(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr9:34635716-34635717(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:34635800-34635801(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960 chr9:34636773-34636774(-) m6A exon//intron       24284625//27773535 chr9:34636793-34636794(-) m6A exon//intron       24284625//27773535 chr9:34636798-34636799(-) m6A exon//intron       24284625//27773535 chr9:34636825-34636826(-) m6A exon//intron       24284625//27773535 chr9:34637193-34637194(-) m6A exon//intron       24284625//22575960 chr9:34637410-34637411(-) m6A 5'UTR//CDS//exon       24284625//27773536//22575960 chr9:34637459-34637460(-) m6A 5'UTR//exon//intron       24284625//27773536 chr9:34637466-34637467(-) m6A 5'UTR//exon//intron       24284625//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-297	Exosome Serum     18589210 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	SIGMAR1	Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-297
Interactor2: SIGMAR1

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	miRanda//miRDB//miRMap//Targetscan
Support Database	ViRBase

References:

PMID	33675361	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	Neonatal rat cardiomyocytes//HEK 293 T cells	Interactor2 expression	Upregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.