Detail Information

Basic Information:


  VIRBase ID:  

HHID00105293

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-421:           ACE2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-421 ACE2
miRBase
Accession/Entrez ID		 MIMAT0003339 59272
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ACEH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-421
rs1242787258 chrX:74218395    C/A
rs745635404 chrX:74218394    G/A
rs769659528 chrX:74218396    C/T
rs780868278 chrX:74218393    C/T
rs1345251789 chrX:74218410    T/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACE2
chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535
chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535
chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535
chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535
chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535
chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535
chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535
chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-421
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Plasma     23663360
Exosome Endothelial cells     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
ACE2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-421
Sensorad 99342 Drug sensitive
Tetrangulol 99188 Drug sensitive
Midostaurin 9829523 Drug resistant
5-Iodo-8-quinolinol 96111 Drug sensitive
Hydrazinecarboximidamide, 2,2'-(carbonylbis(imino-3,1-phenyleneethylidyne))bis-, hydrochloride 9577144 Drug sensitive
Actinomycin X4357G methoxime 9573583 Drug sensitive
Benzoyl leuco methylene blue 94975 Drug sensitive
Dichlorodipropylstannane 93562 Drug sensitive
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
Allyl 2,4,6-tribromophenyl ether 76767 Drug sensitive
Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive
Edatrexate 6917908 Drug sensitive
Laurolinium acetate 67354 Drug sensitive
3-Hydroxy-3'-nitro-2-naphthanilide 67277 Drug sensitive
NO Data IN this field 6711510 Drug sensitive
Reactive Blue 2 656725 Drug sensitive
Lanatoside C 656630 Drug sensitive
Neocuproine 65237 Drug sensitive
(2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive
Piriqualone 6015423 Drug sensitive
trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Artelasticin 5471311 Drug sensitive
Antineoplastic-690266 5469577 Drug sensitive
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
Curromycin A.B mixture 54608021 Drug sensitive
Antineoplastic-328785 54607693 Drug sensitive
Di-p-tolyliodinium bromide 54601177 Drug sensitive
4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug sensitive
Vorinostat 5311 Drug sensitive
Peridinin 5289155 Drug sensitive
Erioflorin acetate 5281443 Drug sensitive
8-Hydroxymanzamine A 5270765 Drug sensitive
Propyl gallate 4947 Drug resistant
6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive
(S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 46907787 Drug sensitive
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
Ossirene 451379 Drug sensitive
BAS100 Monohydrate 45028404 Drug sensitive
Mycophenolic acid 446541 Drug sensitive
Isopinnatal 44558939 Drug sensitive
Calactin 441849 Drug sensitive
Trichopolyn 431962 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide 42640 Drug sensitive
Ethanone, 1-[3-(bromomethyl)-1,4-dioxido-2-quinoxalinyl]- 404859 Drug sensitive
Mechlorethamine 4033 Drug sensitive
Rogiolol 402519 Drug sensitive
2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive
Artelastin 399488 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
Asimicinone 393461 Drug sensitive
Sjg-136 393111 Drug sensitive
2-(5-Amino-1-methyl-4,7-dioxoindol-3-yl)-4-methylthiazole 392620 Drug sensitive
Antineoplastic-690270 391307 Drug sensitive
5,8-Quinolinedione, 2-methyl- 388305 Drug sensitive
2-(1-Propynyl)estradiol 388008 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive
(1R)-3,3-Dibromocamphor 376765 Drug sensitive
N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive
Sanguilutine pseudobase 371258 Drug sensitive
7-Chloro-1-methyl-phenothiazone 369386 Drug sensitive
Tetrakis(8-chinolineolato)titanium(IV)-tetrahydrochloride 368279 Drug sensitive
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug resistant
7,12-Epidioxybenz[a]anthracene, 7,12-dihydro-7-methyl- 362095 Drug sensitive
Buellolide 337850 Drug sensitive
Predorine 333830 Drug sensitive
Rustaiyan A 324967 Drug sensitive
2,2',3,3'-Tetrahydroxy-1,1'-binaphthyl 316673 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
Cytosine, 1beta-D-arabinofuranosyl-N(sup 4)-stearoyl- 304673 Drug sensitive
1,1-Dimethyl-5-(2-naphthalenyl)dithiobiuret 3004012 Drug sensitive
2-Chloro-5-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]butyl]benzenesulfonyl fluoride;ethanesulfonic acid 278692 Drug sensitive
Digoxin 2724385 Drug sensitive
Chlorambucil 2708 Drug sensitive
4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive
Gitoxoside 261947 Drug sensitive
Solacongestidine 258526 Drug sensitive
Hydrazine sulfate 24842 Drug sensitive
Antibiotic U 29135 24196291 Drug sensitive
Drostanolone propionate 224004 Drug sensitive
Scillirosidin, glycoside 222160 Drug sensitive
(1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug sensitive
Nile Blue 2B 20520 Drug sensitive
Actinomycin VII 20055431 Drug sensitive
Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive
8-Hydroxyquinoline 1923 Drug sensitive
5-Nitroso-8-hydroxyquinoline 19103 Drug sensitive
8-Chloro-cyclicamp 17856967 Drug sensitive
4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug sensitive
P-Dioxane,5-bis[(benzoyloxymercuri)methyl]- 16683647 Drug sensitive
Dihydroartemisinin (mixture of alpha and beta isomers) 16399850 Drug sensitive
Dihydrotriazine derivative 160202 Drug sensitive
Antineoplastic-633273 15954131 Drug sensitive
Thevetin 159331 Drug sensitive
(2Z,9E,13Z,15E)-4',11-Dihydroxy-2,4',9-trimethylspiro[3-aza-1(2,4)-thiazolacyclohexadecaphanene-6,3'-[1,2]dithiolane]-9,13,15-triene-4,5',12-trione 2'-oxide 154730760 Drug sensitive
Ammonium tetrathiomolybdate 15251598 Drug sensitive
Dibromsalan 14839 Drug sensitive
[(1R,5R)-16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate 146159135 Drug resistant
(5S,10S,13R,14S)-3-[3,4-Dihydroxy-6-methyl-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,14-dihydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde 146156945 Drug sensitive
(1S,3S,5'R,6S,6'S,8R,9Z,14R,15S,16R,17R,18R,19S,20S,21E,25S,27S,29R)-3,14,15,17,19,20-Hexahydroxy-6'-[(2S)-2-hydroxybutyl]-16-[(2S,4R,5S,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5',6,14,18,20,29-hexamethylspiro[4,24,28-trioxatricyclo[23.3.1.03,8]nonacosa-9,21-diene-27,2'-oxane]-23-one 139589095 Drug sensitive
(1S,3S,6'R,7S,15R,16R,17S,18R,19R,20S,21R,22E,26S,28R,30R)-17-[(2S,5S,6S)-5-(Dimethylamino)-6-methyloxan-2-yl]oxy-3,15,16,18,20,21-hexahydroxy-6'-[(2R)-2-hydroxybutyl]-5,5,15,19,21,30-hexamethylspiro[4,25,29-trioxatricyclo[24.3.1.03,7]triaconta-8,22-diene-28,2'-oxane]-24-one 139583769 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
Acid Alizarine Red B 135565636 Drug sensitive
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug sensitive
(1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug sensitive
Methyl (1S,10R,11S,12S)-11-acetyloxy-12-ethyl-4-[(13R,15R,17R)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 133126830 Drug sensitive
Actinomycin D, 93% 131954673 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
Astraphloxin 12299852 Drug sensitive
2,2'-Bioxirane 11254 Drug sensitive
p-Toluquinone 11122 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
Phthiocol 10221 Drug sensitive
(7S,9S)-7-[[(3As,4S,7aS)-1-[[(3aS,4S,7aS)-4-methyl-6-[[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]-2,3a,4,6,7,7a-hexahydropyrano[4,3-d][1,3]oxazol-1-yl]methyl]-4-methyl-2,3a,4,6,7,7a-hexahydropyrano[4,3-d][1,3]oxazol-6-yl]oxy]-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 101713728 Drug sensitive
15,16-Dihydrocuracin A 101683509 Drug sensitive
(1S,2R,4R,6S,11R,12S,15R,18S,19R,20R,21S,23R,26R)-15-Hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.11,20.02,12.04,6.06,11.015,19.018,23.021,26]triacont-8-ene-10,16,25,30-tetrone 101528280 Drug sensitive
(3S,6S)-1,4-Dimethyl-3,6-bis[(2R)-3,3,3-trichloro-2-methylpropyl]piperazine-2,5-dione 101425118 Drug sensitive
Chimaphilin 101211 Drug sensitive
tunicamycin - Drug resistant
vernonioside c - Drug resistant
(1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive
(z) 3,3',4,5-tetramethoxystilbene - Drug sensitive
1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug sensitive
1,6,7,8-tetra-o-phenylcarbamoylcastnospermine - Drug sensitive
1,8-naphthyridin-4(1h)-one, 2-(4-fluorophenyl)-5-methyl- - Drug sensitive
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug sensitive
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive
1-piperidinecarbodithioic acid, antimony complex - Drug sensitive
2,2':5',3-terthiophene-5-carboxaldehyde - Drug sensitive
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive
2-thienyl-5'-pyrrole-2',5-thiophene-2-aldehyde - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 10-methoxy- - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-methyl- - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-phenyl- - Drug sensitive
aquatris(1,3-diphenylpropane-1,3-dionato)neodymium(iii) - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
benzonitrile, 2-amino-3,5-dinitro- (9ci) - Drug sensitive
n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug sensitive
urea, n'-(5,6-dichloro-1h-benzimidazol-2-yl)-n,n-dimethyl- - Drug sensitive
(s)(-)-methyl perillate - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
actinomycin pip t.beta. - Drug sensitive
antineoplastic-615538 - Drug sensitive
antineoplastic-624659 - Drug sensitive
antineoplastic-625543 - Drug sensitive
antineoplastic-641296 - Drug sensitive
antineoplastic-641297 - Drug sensitive
Camptothecin Derivative - Drug sensitive
Carboxyphthalatoplatinum - Drug sensitive
chlorambucil-spermidine - Drug sensitive
Copper(II) complex with a thiosemicarbazone as a ligand - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
digitoxigenin glycoside - Drug sensitive
Indenoisoquinoline derivative - Drug sensitive
leucinostatine d - Drug sensitive
Methotrexate Derivative - Drug sensitive
phenylmercuric acetate (usan) - Drug sensitive
Soluble Baker's Antifol - Drug sensitive
Tetraplatin - Drug sensitive
thiadiazines - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-421
Cytarabine 6253 Drug interaction    RC00006415
Gemcitabine 60750 Drug interaction    RC00006417
Eloxatine 5310940 Drug interaction    RC00006418
5-Fluorouracil 3385 Drug interaction    RC00006414
Doxorubicin 31703 Drug interaction    RC00006416
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00006413
Marine fungal metabolite 1386A - Drug interaction    RC00006419
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-421
Topotecan       60700
Palbociclib       5330286

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-421
Interactor2: ACE2

Evidence Support:


Prediction-Evidence miRanda//miRBase//miRWalk//Targetscan
Support Database ViRBase

References:


PMID 32992681 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Table 1 shows a list of novel potential candidate miRNAs against ACE2 gene that were not studied previously.

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