Basic Information:

  VIRBase ID:  

HHID00105268

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-455-5p:  MIMAT0003150          CCR5:  NM_000579     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-455-5p	CCR5
miRBase Accession/Entrez ID	MIMAT0003150	1234
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CC-CKR-5//CCCKR5//CCR-5//CD195//CKR-5//CKR5//CMKBR5//IDDM22

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-455-5p	rs1288139869 chr9:114209467    A/G rs1414847416 chr9:114209466    C/T rs552585852 chr9:114209470    G/A rs552585852 chr9:114209470    G/T rs776650840 chr9:114209469    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCR5	chr3:46417215(+) A-I      3'UTR chr3:46417221(+) A-I      3'UTR chr3:46417219(+) A-I      3'UTR chr3:46417218(+) A-I      3'UTR chr3:46417270(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCR5	chr3:46417171(+) A-I exon 3'UTR    15258596 chr3:46417220(+) A-I exon 3'UTR    15258596 chr3:46417272(+) A-I exon 3'UTR    15258596 chr3:46417283(+) A-I exon 3'UTR    15258596

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCR5	chr3:46414562-46414563(+) m6A CDS       - chr3:46414676-46414677(+) m6A CDS       - chr3:46415165-46415166(+) m6A CDS       - chr3:46415219-46415220(+) m6A CDS       - chr3:46415242-46415243(+) m6A CDS       - chr3:46415309-46415310(+) m6A CDS       - chr3:46415457-46415458(+) m6A 3'UTR       - chr3:46416453-46416454(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-455-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698 Exosome Serum     18589210 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Tongue tissue     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	CCR5	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-455-5p	4-Methyl-3-{[6-(Methylsulfonyl)quinolin-4-Yl]amino}phenol 9927432 Drug sensitive N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione 98137101 Drug sensitive CID 9604911 9604911 Drug sensitive 7-Hydroxystaurosporine 72271 Drug sensitive 5-Nitro-N-(pyridin-3-ylmethyl)furan-2-carboxamide 693996 Drug sensitive Chalcone analog 6296717 Drug resistant 3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug resistant Antibiotic 1907-VIII 5477807 Drug resistant 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug resistant Simvastatin 54454 Drug sensitive Lovastatin 53232 Drug sensitive N'-(3-Pyridin-2-ylisoquinolin-1-yl)pyridine-2-carboximidamide 463108 Drug resistant Latrunculin a 445420 Drug sensitive Trichopolyn 431962 Drug resistant 1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug sensitive Thiosangivamycin 3580213 Drug resistant Dasatinib 3062316 Drug sensitive [(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant 6,7-Dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride 21701565 Drug sensitive 5-Fluoro deoxy uridine 10mer 16130072 Drug sensitive N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive Butyltriphenylphosphonium bromide 159628 Drug resistant Antineoplastic-633273 15954131 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 43-Dioxypectenotoxin 131751434 Drug sensitive Berberine chloride 12456 Drug resistant p-Toluquinone 11122 Drug resistant 15,16-Dihydrocuracin A 101683509 Drug resistant 1,4-benzenediamine (9ci), n-butyl-n'-phenyl- - Drug resistant phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug resistant dichlorobisoxinatotitanium(iv) - Drug resistant leucinostatine d - Drug resistant n-acetyl-4-s-cystaminyl phenol - Drug resistant tetra(isobutenyl)antimony bromide - Drug resistant 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive (-)-furodysinin - Drug sensitive geldanamycin dimethylglycinate - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-455-5p	Gemcitabine 60750 Drug interaction    RC00005824 Vincristine 5978 Drug interaction    RC00005821 Prednisone 5865 Drug interaction    RC00005820 Temozolomide 5394 Drug interaction    RC00005819 Etoposide 36462 Drug interaction    RC00005823 5-Fluorouracil 3385 Drug interaction    RC00005818 Doxorubicin 31703 Drug interaction    RC00005822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005817 Verapamil 2520 Drug interaction    RC00005816 Docetaxel 148124 Drug interaction    RC00005826 Methotrexate 126941 Drug interaction    RC00005825

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-455-5p	Cisplatin 5702198       21575166 5-Fluorouracil 3385       25356050

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-455-5p	Panobinostat       6918837 Irinotecan       60838 l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-455-5p
Interactor2: CCR5

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qPCR//Western blot
Prediction-Evidence	microRNA.org//Targetscan
Support Database	ViRBase

References:

PMID	33675361	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	LNCAP cells//DU145 cells	Interactor2 expression	Downregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.