Detail Information

Basic Information:


  VIRBase ID:  

HHID00105247

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-497-5p:           TMPRSS2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-497-5p TMPRSS2
miRBase
Accession/Entrez ID		 MIMAT0002820 7113
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PRSS10

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-497-5p
rs1050536403 chr17:7017990    T/G
rs1217216293 chr17:7017999    G/A
rs1239642436 chr17:7017988    A/G
rs1283992109 chr17:7017989    G/A
rs1315164260 chr17:7017979    A/G
rs753897817 chr17:7017984    CCA/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMPRSS2
chr21:42853862(-) A-I      intronic
chr21:42853848(-) A-I      intronic
chr21:42853888(-) A-I      intronic
chr21:42853850(-) A-I      intronic
chr21:42853879(-) A-I      intronic
chr21:42857482(-) A-I      intronic
chr21:42857493(-) A-I      intronic
chr21:42857494(-) A-I      intronic
chr21:42857532(-) A-I      intronic
chr21:42861840(-) A-I      intronic
chr21:42863176(-) A-I      intronic
chr21:42863181(-) A-I      intronic
chr21:42864020(-) A-I      intronic
chr21:42857454(-) A-I      intronic
chr21:42852821(-) A-I      intronic
chr21:42852811(-) A-I      intronic
chr21:42868840(-) A-I      intronic
chr21:42864037(-) A-I      intronic
chr21:42852802(-) A-I      intronic
chr21:42852784(-) A-I      intronic
chr21:42852783(-) A-I      intronic
chr21:42852698(-) A-I      intronic
chr21:42868853(-) A-I      intronic
chr21:42853773(-) A-I      intronic
chr21:42853747(-) A-I      intronic
chr21:42852838(-) A-I      intronic
chr21:42868879(-) A-I      intronic
chr21:42853786(-) A-I      intronic
chr21:42853787(-) A-I      intronic
chr21:42853866(-) A-I      intronic
chr21:42853876(-) A-I      intronic
chr21:42853901(-) A-I      intronic
chr21:42853902(-) A-I      intronic
chr21:42853905(-) A-I      intronic
chr21:42853936(-) A-I      intronic
chr21:42857436(-) A-I      intronic
chr21:42852837(-) A-I      intronic
chr21:42852694(-) A-I      intronic
chr21:42857467(-) A-I      intronic
chr21:42857468(-) A-I      intronic
chr21:42857476(-) A-I      intronic
chr21:42859902(-) A-I      ncRNA
chr21:42859884(-) A-I      ncRNA
chr21:42859893(-) A-I      ncRNA
chr21:42868835(-) A-I      intronic
chr21:42859992(-) A-I      intronic
chr21:42855936(-) A-I      intronic
chr21:42868944(-) A-I      intronic
chr21:42868836(-) A-I      intronic
chr21:42852668(-) A-I      intronic
chr21:42859993(-) A-I      intronic
chr21:42869010(-) A-I      intronic
chr21:42863353(-) A-I      intronic
chr21:42868900(-) A-I      intronic
chr21:42868945(-) A-I      intronic
chr21:42852703(-) A-I      intronic
chr21:42860827(-) A-I      intronic
chr21:42859858(-) A-I      ncRNA
chr21:42859831(-) A-I      ncRNA
chr21:42859844(-) A-I      ncRNA
chr21:42858403(-) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMPRSS2
chr21:42858403(-) A-I intron -    15342557
chr21:42858406(-) A-I intron -    15342557
chr21:42859670(-) A-I intron -    15342557
chr21:42859831(-) A-I intron -    15342557   //15258596
chr21:42859844(-) A-I intron -    15342557   //15258596
chr21:42859858(-) A-I intron -    15342557   //15258596
chr21:42859884(-) A-I intron -    15342557   //15258596
chr21:42859893(-) A-I intron -    15342557   //15258596
chr21:42859902(-) A-I intron -    15342557   //15258596
chr21:42868835(-) A-I intron -    15342557
chr21:42868836(-) A-I intron -    15342557
chr21:42868864(-) A-I intron -    15342557
chr21:42868900(-) A-I intron -    15342557
chr21:42868905(-) A-I intron -    15342557
chr21:42868944(-) A-I intron -    15342557
chr21:42868945(-) A-I intron -    15342557
chr21:42868950(-) A-I intron -    15342557
chr21:42869010(-) A-I intron -    15342557
chr21:42869014(-) A-I intron -    15342557
chr21:42869073(-) A-I intron -    15342557
chr21:42853823(-) A-I intron -    21960545
chr21:42853826(-) A-I intron -    21960545
chr21:42853866(-) A-I intron -    21960545
chr21:42855839(-) A-I intron -    21960545
chr21:42855936(-) A-I intron -    21960545
chr21:42855984(-) A-I intron -    21960545
chr21:42857419(-) A-I intron -    21960545
chr21:42857454(-) A-I intron -    21960545
chr21:42857468(-) A-I intron -    21960545
chr21:42857493(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMPRSS2
chr21:42836773-42836774(-) m6A 3'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-497-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Mast cells     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
TMPRSS2
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-497-5p
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant
Acridine Yellow G 8672 Drug resistant
1,9-Pyrazoloanthrone 8515 Drug resistant
5-Methyl-1,10-phenanthroline 72791 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
Berberine iodide 72350 Drug sensitive
Thiocoraline 70698112 Drug resistant
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Kikubasaponin 6712587 Drug resistant
Ixabepilone 6445540 Drug sensitive
5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one 5477132 Drug resistant
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 5386397 Drug sensitive
Reumycin 5351216 Drug resistant
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
Centaureidin 5315773 Drug sensitive
Alvocidib 5287969 Drug resistant
Amonafide 50515 Drug resistant
Bindschedler's green 458960 Drug sensitive
Justicidin B 442882 Drug resistant
Massoia lactone 39914 Drug resistant
1H-Indole, 5-bromo-3-[2-(2-pyridinyl)-4-thiazolyl]- 397551 Drug resistant
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
Miltefosine 3599 Drug resistant
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
L-Cysteine, S-[(4-chlorophenyl)diphenylmethyl]- 275977 Drug sensitive
2-(7-Aminotriazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol 251928 Drug resistant
9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug resistant
Olaparib 23725625 Drug sensitive
Spongiaquinone 23424796 Drug sensitive
Verrucarin A 9,10-epoxide 181390 Drug resistant
Aklavin 149755 Drug resistant
Perifosine 148177 Drug resistant
Edelfosine 1392 Drug resistant
(1R,6R,13S)-16,17-Dimethoxy-6-propan-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one 13845974 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Abiraterone 132971 Drug sensitive
Octadecylphosphocholine 125219 Drug resistant
3-(4-(5-Methoxy-1H-benzo[d]imidazol-2-yl)phenyl)-5-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazole 118624714 Drug sensitive
Pararosaniline hydrochloride 11292 Drug sensitive
1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole 11162021 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
4-methoxy-2,6-bis[hydroxy(methyl)amino]-1,3,5-triazine - Drug resistant
arylpurines - Drug resistant
methyl (e)-4-methyl-6-(5-bromo-2-hydroxyphenyl)-4-hexenoate - Drug resistant
tunicamycin - Drug resistant
2,4-diethoxyestra-1,3,5(10)trien-3,17.beta.-diol - Drug sensitive
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive
N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide - Drug sensitive
naphtho[1,2-b]quinolizinium, 10,13-dimethyl- chloride - Drug sensitive
naphtho[2,1-b]quinolizinium, 7-methyl- chloride - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
2-(4-methylthio-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
peliomycin (usan) - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-497-5p
Bufalin 9547215 Drug interaction    RC00005478
Ethanol 702 Drug interaction    RC00005464
Gemcitabine 60750 Drug interaction    RC00005473
Testosterone 6013 Drug interaction    RC00005470
Vincristine 5978 Drug interaction    RC00005469
Temozolomide 5394 Drug interaction    RC00005468
Eloxatine 5310940 Drug interaction    RC00005477
Diethylstilbestrol 448537 Drug interaction    RC00005476
Paclitaxel 36314 Drug interaction    RC00005472
5-Fluorouracil 3385 Drug interaction    RC00005467
Doxorubicin 31703 Drug interaction    RC00005471
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005466
Verapamil 2520 Drug interaction    RC00005465
Erlotinib 176870 Drug interaction    RC00005475
Gefitinib 123631 Drug interaction    RC00005474
TRAIL therapy - Drug interaction    RC00005481
platinum-based doublet chemotherapy - Drug interaction    RC00005479
Rituximab - Drug interaction    RC00005480

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-497-5p
Interactor2: TMPRSS2

Evidence Support:


Prediction-Evidence microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database ViRBase

References:


PMID 33428154 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

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