Basic Information:

  VIRBase ID:  

HHID00105245

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-495-3p:  MIMAT0002817          ACE2:  NM_021804     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-495-3p	ACE2
miRBase Accession/Entrez ID	MIMAT0002817	59272
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACEH

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-495-3p	rs1267369627 chr14:101033816    T/C rs1283374729 chr14:101033823    C/A rs1286545781 chr14:101033804    A/C rs1329943153 chr14:101033817    G/A rs199783139 chr14:101033820    C/T rs761362302 chr14:101033811    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACE2	chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535 chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535 chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535 chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535 chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535 chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535 chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535 chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-495-3p	Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849
	ACE2	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-495-3p	8-Aminoadenosine 96851 Drug resistant (3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug resistant 1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug resistant Berberine iodide 72350 Drug sensitive Nobiletin 72344 Drug resistant 1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant 1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant Silver mesylate 6712944 Drug resistant 2'-Bromo-4'-epi-daunorubicin 6711997 Drug sensitive Pyrazolo[1,5-b]pyridazine deriv. 97 6539439 Drug resistant Crotonoside 65085 Drug resistant Jatrophon 6325446 Drug resistant Ketone, methyl 2-pyridyl, 4,4-dimethyl-3-thiosemicarbazone 5843399 Drug resistant 2-Azaadenine 5480214 Drug resistant 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive [(1H-Benzimidazole-2-yl)dithio]-9H-purine 54613148 Drug resistant Biantrazole 54607781 Drug sensitive Selendale 54601159 Drug sensitive 2-Methylolivacinium acetate 5458752 Drug sensitive Ovatifolin acetate 5358419 Drug resistant Xestin A 5352066 Drug resistant 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant Vorinostat 5311 Drug resistant Eupachlorin 5281446 Drug resistant 6-Bromosangivamycin 470030 Drug resistant Patulin 4696 Drug resistant Justicidin B 442882 Drug resistant Suavedol 442245 Drug resistant Musennin 441933 Drug sensitive Antibiotic X-14766A 434840 Drug sensitive Elliptinium acetate 42722 Drug sensitive Carboplatin 426756 Drug sensitive Mitoxantrone 4212 Drug sensitive 5,8-Quinolinedione, 2-methyl- 388305 Drug resistant Uracil, 3-methyl-6-(phenylhydrazino)- 385874 Drug resistant Stereoisomer of NSC 674066-O 384359 Drug resistant 1-Azido-2-formyl-benzo[ij]quinolizin-3-one 381901 Drug resistant Carquniostatin B 380452 Drug resistant 2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant 2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug resistant Antineoplastic-D648114 372647 Drug sensitive 2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive 2-Hydroxy discorhabdin D 362391 Drug resistant 1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant Thiosangivamycin 3580213 Drug resistant Haloprogin 3561 Drug resistant Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug sensitive p-Bromophenacyl benzoate 345792 Drug resistant Maxima isoflavone D 343081 Drug sensitive Ellipticine 3213 Drug sensitive 8-Trichloromethyldihydroberberine 320713 Drug sensitive 9-Methoxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium iodide 3086380 Drug sensitive 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive Clomifene citrate 3033832 Drug resistant 4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant [(5Z)-1,7,7-Trimethyl-5-(nitromethylene)-6-oxo-norbornan-2-yl] acetate 3004516 Drug resistant 1-(3-Diethylarsino-3-thio-2-methyl-1-oxopropyl)-L-proline 24203225 Drug resistant Sarcoviolin 24202820 Drug sensitive Tartrolon b 23685389 Drug sensitive Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug sensitive N-Butyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 219760 Drug resistant 2-Bromo-4-methyl-1,3,5-trinitrobenzene 219376 Drug resistant Kinetin riboside 20345 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant Sangivamycin monohydrate 16219974 Drug resistant Jolkinolide B 161954 Drug resistant Paucin 161538 Drug resistant [(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant Methyl ester prodigiosene 136040158 Drug resistant Oxanthrazole 135502299 Drug sensitive Formycin b 135449281 Drug resistant Salicylidene salicylhydrazide 135445765 Drug resistant Allopurinol 135401907 Drug resistant 43-Dioxypectenotoxin 131751434 Drug sensitive (2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug resistant 1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug sensitive Litmomycin 12310334 Drug resistant 2,9-Dimethylellipticinium acetate 10472068 Drug sensitive 15,16-Dihydrocuracin A 101683509 Drug resistant 2-N-Methyl-6-oxaellipticinium acetate 10018975 Drug sensitive 1-[5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole - Drug resistant 2-(p-nitrophenoxy)carbonyl-1,2-dihydroellipticine - Drug resistant 2,6-bis(4-morpholinylmethyl)cyclohexanone,dihydrochloride - Drug resistant 4-piperidinone, 1-methyl-2,6-bis[(2-nitrophenyl)methylene]- - Drug resistant 6-(4-hydroxy-2-methylphenyl)-2-(4-(methylsulfonyl)phenyl)-4,5-dihydropyridazin-3(2H)-one - Drug resistant ethyl, methoxy, prodigisine - Drug resistant furan-2(3h)-one, 5-(4-methylphenyl)-3,3-diphenyl- - Drug resistant inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant bafilomycin antibiotic - Drug resistant bis(2-nitrophenyl)sulfilimine - Drug resistant geldanamycin analog - Drug resistant granatomycin a - Drug resistant o-linoleoyl-2-butoxy-1-desoamine - Drug resistant xenorhabdin 1 - Drug resistant 1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug sensitive 1,4-bis(n-cysteinyldiethylamino)-5,8-dihydroxy anthraquinon - Drug sensitive naphtho[1,2-b]quinolizinium, 9-methyl-, bromide - Drug sensitive phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive 2-(n-d-glysoyl)aminobenzothiazole - Drug sensitive 2-methylellpticinium - Drug sensitive Annamycin Liposomal - Drug sensitive Camptothecin Derivative - Drug sensitive CI-921: amsacrine derivative - Drug sensitive protein: pahiv4 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-495-3p	Gemcitabine 60750 Drug interaction    RC00005429 Eloxatine 5310940 Drug interaction    RC00005430 Carboplatinum 38904 Drug interaction    RC00005428 Doxorubicin 31703 Drug interaction    RC00005427 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005426 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00005431

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-495-3p
Interactor2: ACE2

Evidence Support:

Prediction-Evidence	miRanda//miRBase//miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	32992681	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Table 1 shows a list of novel potential candidate miRNAs against ACE2 gene that were not studied previously.