Detail Information

Basic Information:


  VIRBase ID:  

HHID00105238

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-432-5p:           ACE2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-432-5p ACE2
miRBase
Accession/Entrez ID		 MIMAT0002814 59272
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ACEH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-432-5p
rs1004111020 chr14:100884513    G/A
rs1295999868 chr14:100884515    G/A
rs1359550541 chr14:100884511    T/C
rs755842383 chr14:100884505    A/G
rs757061476 chr14:100884503    G/A

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACE2
chrX:15579319-15579320(-) m6A 3'UTR//exon       27773535
chrX:15579343-15579344(-) m6A 3'UTR//exon       27773535
chrX:15579366-15579367(-) m6A 3'UTR//exon       27773535
chrX:15579420-15579421(-) m6A 3'UTR//exon       27773535
chrX:15579431-15579432(-) m6A 3'UTR//intron       27773535
chrX:15579618-15579619(-) m6A 3'UTR//intron       27773535
chrX:15579631-15579632(-) m6A 3'UTR//intron       27773535
chrX:15579696-15579697(-) m6A 3'UTR//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-432-5p
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Endothelial cells     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
ACE2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-432-5p
Oxaliplatin 9887053 Drug sensitive
8-Aminoadenosine 96851 Drug resistant
Tiotixene 941651 Drug resistant
10,11-Methylenedioxy-20S-camptothecin 72403 Drug sensitive
2'-Bromo-4'-epi-daunorubicin 6711997 Drug sensitive
(9S)-7-(4-Amino-5-hydroxy-6-methyloxan-2-yl)oxy-9-(2-fluoroacetyl)-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione 6711360 Drug sensitive
Antineoplastic-301477 6711219 Drug sensitive
Pyrazolo[1,5-b]pyridazine deriv. 97 6539439 Drug resistant
1,3,8-Trihydroxy-6-methoxyanthracene-9,10-dione 636723 Drug resistant
Deferoxamine hydrochloride 62880 Drug sensitive
Daunorubicin hydrochloride 62770 Drug sensitive
Cytarabine 6253 Drug sensitive
Gallium nitrate 61635 Drug resistant
Bizelesin 60794 Drug sensitive
Gemcitabine 60750 Drug sensitive
Topotecan 60700 Drug sensitive
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug resistant
Floxuridine 5790 Drug sensitive
Mitomycin 5746 Drug sensitive
Cisplatin 5702198 Drug sensitive
2-Azaadenine 5480214 Drug resistant
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
Biantrazole 54607781 Drug sensitive
Bleomycin 5460769 Drug sensitive
Betuletol 5459196 Drug sensitive
[2-[2-[(1R,2S)-2-[[6-Amino-2-[1-[(2S)-2,3-diamino-3-oxopropyl]-4-oxoazetidin-2-yl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S)-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-[2-[4-[4-[2-(2-hydroxypropylamino)ethylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-1-oxobutan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate 5458321 Drug sensitive
1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug resistant
Streptonigrin 5298 Drug sensitive
Ammonia; dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498559 Drug sensitive
Methoxycamptothecin 494089 Drug sensitive
Musennin 441933 Drug sensitive
Antibiotic X-14766A 434840 Drug sensitive
Elliptinium acetate 42722 Drug sensitive
Carboplatin 426756 Drug sensitive
Mitoxantrone 4212 Drug sensitive
Chelocardin dodecyl sulfate 415844 Drug sensitive
Fagaronine chloride 40304 Drug sensitive
Massoia lactone 39914 Drug resistant
Sjg-136 393111 Drug sensitive
Uracil, 3-methyl-6-(phenylhydrazino)- 385874 Drug resistant
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug resistant
Antineoplastic-D648114 372647 Drug sensitive
Amchlorguanidine 364435 Drug sensitive
1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant
Haloprogin 3561 Drug resistant
p-Bromophenacyl benzoate 345792 Drug resistant
Phenyl gallate 333279 Drug sensitive
Pinafide 327045 Drug sensitive
Ellipticine 3213 Drug sensitive
Cytosine arabinoside monophosphate 314 Drug sensitive
2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive
Clomifene citrate 3033832 Drug resistant
Chlorambucil 2708 Drug sensitive
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug sensitive
Camptothecin 24360 Drug sensitive
Sarcoviolin 24202820 Drug sensitive
Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug sensitive
N-Butyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 219760 Drug resistant
Amsacrine 2179 Drug sensitive
Pirarubicin hydrochloride 20846247 Drug sensitive
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant
Sulfanilanilide, 4'-(9-acridinylamino)- 148802 Drug sensitive
Methyl (3'R)-3,4',9',10-tetrahydroxy-3'-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-7'-methoxy-5',8',9-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2'-3H-benzo[f][1]benzofuran]-7-carboxylate 137326876 Drug sensitive
Oxanthrazole 135502299 Drug sensitive
1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive
Saintopin 131350 Drug sensitive
1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug sensitive
Litmomycin 12310334 Drug resistant
Pepleo 122804 Drug sensitive
Bialamicol 10304 Drug resistant
Clomesone 100651 Drug sensitive
N,N-Bis(2-chloroethyl)-p-toluidine 100400 Drug sensitive
benzene, 1-methoxy-4-(2-nitroethenyl)-, (e)- - Drug resistant
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
granatomycin a - Drug resistant
xenorhabdin 1 - Drug resistant
1,1'-biphenyl, 4,4'bis(thiomethyl)- - Drug sensitive
1,4-bis(n-cysteinyldiethylamino)-5,8-dihydroxy anthraquinon - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug sensitive
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive
pyrido[3',4':4,5]thieno[2,3-g]isoquinoline, 6-methyl- - Drug sensitive
2-(n-d-glysoyl)aminobenzothiazole - Drug sensitive
2-methylellpticinium - Drug sensitive
Aminocamptothecin - Drug sensitive
analog of cc-1065 - Drug sensitive
Annamycin Liposomal - Drug sensitive
Anthrapyrazole derivative - Drug sensitive
antineoplastic-d665839 - Drug sensitive
Camptothecin Derivative - Drug sensitive
Carboqone; Carbazilquinone - Drug sensitive
CI-921: amsacrine derivative - Drug sensitive
ether-20 - Drug sensitive
Indenoisoquinoline derivative - Drug sensitive
mitaplatin - Drug sensitive
protein: pahiv4 - Drug sensitive
trimethyl(phenylthio)stannane - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-432-5p
Alocrest 60780 Drug interaction    RC00005407
Vorinostat 5311 Drug interaction    RC00005405
5-Fluorouracil 3385 Drug interaction    RC00005404
Doxorubicin 31703 Drug interaction    RC00005406
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005403
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00005408

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-432-5p
Interactor2: ACE2

Evidence Support:


Prediction-Evidence microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database ViRBase

References:


PMID 33428154 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

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