Detail Information

Basic Information:


  VIRBase ID:  

HHID00105231

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-410-3p:           AGTR1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-410-3p AGTR1
miRBase
Accession/Entrez ID		 MIMAT0002171 185
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AG2S//AGTR1B//AT1//AT1AR//AT1B//AT1BR//AT1R//AT2R1//HAT1R

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-410-3p
rs1223753297 chr14:101065976    G/A
rs1429129856 chr14:101065969    A/C
rs1429129856 chr14:101065969    A/G
rs752457363 chr14:101065975    G/A
rs759098871 chr14:101065970    C/T
rs764779951 chr14:101065974    T/G
rs956040031 chr14:101065977    C/T
rs753277476 chr14:101065968    C/A
rs754190835 chr14:101065961    AAT/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR AGTR1
chr3:148456896(+) A-I      intronic
chr3:148456912(+) A-I      intronic
chr3:148456944(+) A-I      intronic
chr3:148456891(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase AGTR1
chr3:148458958-148458959(+) m6A CDS       24981863
chr3:148459002-148459003(+) m6A CDS       24981863
chr3:148459513-148459514(+) m6A CDS       24981863//27773535
chr3:148459663-148459664(+) m6A CDS       24981863
chr3:148459807-148459808(+) m6A CDS       24981863//27773535
chr3:148459912-148459913(+) m6A 3'UTR       24981863//27773535
chr3:148459953-148459954(+) m6A 3'UTR       24981863//27773535//22608085
chr3:148460030-148460031(+) m6A 3'UTR       24981863//27773535//22608085
chr3:148460035-148460036(+) m6A 3'UTR       24981863//27773535//22608085
chr3:148460057-148460058(+) m6A 3'UTR       24981863//27773535//22608085
chr3:148460087-148460088(+) m6A 3'UTR       24981863//27773535//22608085
chr3:148460114-148460115(+) m6A 3'UTR       24981863//27773535//22608085
chr3:148460136-148460137(+) m6A 3'UTR       24981863//27773535
chr3:148460148-148460149(+) m6A 3'UTR       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-410-3p
Exosome Serum     18589210
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Endothelial cells     -
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
AGTR1
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-410-3p
5-Fluorouracil 3385 Drug interaction    RC00005291
Doxorubicin 31703 Drug interaction    RC00005292
Verapamil 2520 Drug interaction    RC00005290
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-410-3p
5-Fluorouracil 3385       25356050

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-410-3p
Interactor2: AGTR1

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase

References:


PMID 33675361 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line AsPC-1 cells//MIA PaCa-2 cells//PANC-1 cells Interactor2 expression Downregulation
Description In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.

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